{"id":19249,"date":"2020-09-18T05:10:34","date_gmt":"2020-09-17T21:10:34","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=19249"},"modified":"2020-09-26T07:26:55","modified_gmt":"2020-09-25T23:26:55","slug":"lancet-respir-med%e5%9c%a8%e7%ba%bf%e5%8f%91%e8%a1%a8%ef%bc%9aecmo%e6%b2%bb%e7%96%97%e6%96%b0%e5%86%a0%e8%82%ba%e7%82%8e%e5%90%88%e5%b9%b6%e9%87%8d%e5%ba%a6ards%ef%bc%9a%e5%9b%9e%e9%a1%be%e9%98%9f","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=19249","title":{"rendered":"[Lancet Respir Med\u5728\u7ebf\u53d1\u8868]\uff1aECMO\u6cbb\u7597\u65b0\u51a0\u80ba\u708e\u5408\u5e76\u91cd\u5ea6ARDS\uff1a\u56de\u987e\u961f\u5217\u7814\u7a76"},"content":{"rendered":"\n

Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome associated with COVID-19: a retrospective cohort study<\/h1>\n\n\n\n

Matthieu Schmidt, David Hajage, Guillaume Lebreton<\/h3>\n\n\n\n

Lancet Respir Med Published:August 13, 2020 DOI:https:\/\/doi.org\/10.1016\/S2213-2600(20)30328-3<\/a><\/h3>\n\n\n\n

Summary \u6458\u8981<\/h2>\n\n\n\n

Background \u80cc\u666f<\/h3>\n\n\n\n

Patients with COVID-19 who develop severe acute respiratory distress syndrome (ARDS) can have symptoms that rapidly evolve to profound hypoxaemia and death. The efficacy of extracorporeal membrane oxygenation (ECMO) for patients with severe ARDS in the context of COVID-19 is unclear. We aimed to establish the clinical characteristics and outcomes of patients with respiratory failure and COVID-19 treated with ECMO.<\/p>\n\n\n\n

\u53d1\u751f\u91cd\u5ea6ARDS\u7684\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u4e34\u5e8a\u75c7\u72b6\u8fc5\u901f\u8fdb\u5c55\u4e3a\u4e25\u91cd\u4f4e\u6c27\u8840\u75c7\u751a\u81f3\u6b7b\u4ea1\u3002ECMO\u5bf9\u4e8e\u65b0\u51a0\u80ba\u708e\u5bfc\u81f4\u7684ARDS\u60a3\u8005\u7684\u7597\u6548\u5e76\u4e0d\u660e\u786e\u3002\u6211\u4eec\u65e8\u5728\u660e\u786e\u63a5\u53d7ECMO\u6cbb\u7597\u5408\u5e76\u547c\u5438\u529f\u80fd\u8870\u7aed\u7684\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u7684\u4e34\u5e8a\u7279\u5f81\u53ca\u9884\u540e\u3002<\/p>\n\n\n\n

Methods \u65b9\u6cd5<\/h3>\n\n\n\n

This retrospective cohort study was done in the Paris\u2013Sorbonne University Hospital Network, comprising five intensive care units (ICUs) and included patients who received ECMO for COVID-19 associated ARDS. Patient demographics and daily pre-ECMO and on-ECMO data and outcomes were collected. Possible outcomes over time were categorised into four different states (states 1\u20134): on ECMO, in the ICU and weaned off ECMO, alive and out of ICU, or death. Daily probabilities of occupation in each state and of transitions between these states until day 90 post-ECMO onset were estimated with use of a multi-state Cox model stratified for each possible transition. Follow-up was right-censored on July 10, 2020.<\/p>\n\n\n\n

\u8fd9\u9879\u56de\u987e\u961f\u5217\u7814\u7a76\u5728Paris\u2013Sorbonne\u5927\u5b66\u533b\u9662\u7f51\u7edc\u8fdb\u884c\uff0c5\u4e2aICU\u53c2\u52a0\uff0c\u7eb3\u5165\u63a5\u53d7ECMO\u6cbb\u7597\u7684\u65b0\u51a0\u80ba\u708e\u5408\u5e76ARDS\u60a3\u8005\u3002\u6536\u96c6\u60a3\u8005\u4eba\u53e3\u7edf\u8ba1\u5b66\u8d44\u6599\uff0c\u5df2\u7ecfECMO\u524d\u548c\u5e94\u7528ECMO\u8fc7\u7a0b\u4e2d\u6bcf\u65e5\u8d44\u6599\u548c\u9884\u540e\u3002\u6839\u636e\u53ef\u80fd\u7684\u65f6\u95f4\u76f8\u5173\u9884\u540e\u5206\u4e3a4\u79cd\u4e0d\u540c\u72b6\u6001\uff08\u72b6\u6001 1\u20134\uff09\uff1a\u4f7f\u7528ECMO\u8fc7\u7a0b\u4e2d\uff0c\u4ecd\u5728 ICU\u4f46\u8131\u79bb ECMO\uff0c\u5b58\u6d3b\u4e14\u8f6c\u51faICU\uff0c\u6216\u6b7b\u4ea1\u3002\u91c7\u7528\u591a\u72b6\u6001Cox\u6a21\u578b\uff0c\u9488\u5bf9\u6bcf\u79cd\u53ef\u80fd\u8f6c\u53d8\u5206\u5c42\uff0c\u8ba1\u7b97\u6bcf\u65e5\u5728\u5404\u79cd\u72b6\u6001\u53ca\u4e4b\u95f4\u8f6c\u53d8\u7684\u6982\u7387\u3002\u968f\u8bbf\u622a\u6b62\u52302020\u5e747\u670810\u65e5\u3002<\/p>\n\n\n\n

Findings \u7ed3\u679c<\/h3>\n\n\n\n

From March 8 to May 2, 2020, 492 patients with COVID-19 were treated in our ICUs. Complete day-60 follow-up was available for 83 patients (median age 49 [IQR 41\u201356] years and 61 [73%] men) who received ECMO. Pre-ECMO, 78 (94%) patients had been prone-positioned; their median driving pressure was 18 (IQR 16\u201321) cm H2<\/sub>O and PaO2<\/sub>\/FiO2<\/sub>\u00a0was 60 (54\u201368) mm Hg. At 60 days post-ECMO initiation, the estimated probabilities of occupation in each state were 6% (95% CI 3\u201314) for state 1, 18% (11\u201328) for state 2, 45% (35\u201356) for state 3, and 31% (22\u201342) for state 4. 35 (42%) patients had major bleeding and four (5%) had a haemorrhagic stroke. 30 patients died.<\/p>\n\n\n\n

\u4ece2020\u5e743\u67088\u65e5\u81f35\u67082\u65e5\uff0cICU\u5171\u6536\u6cbb492\u540d\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u3002\u5176\u4e2d83\u540d\uff08\u4e2d\u4f4d\u5e74\u9f84 49 [IQR 41\u201356] \u5c81\uff0c61\u540d [73%] \u4e3a\u5973\u6027\uff09\u60a3\u8005\u6709\u5b8c\u6574\u768460\u5929\u968f\u8bbf\u8bb0\u5f55\u3002\u5728ECMO\u524d\uff0c78\u540d (94%) \u60a3\u8005\u63a5\u53d7\u4fef\u5367\u4f4d\uff1b\u9a71\u52a8\u538b\u4e2d\u4f4d\u657018 (IQR 16\u201321) cm H2<\/sub>O\uff0cPaO2<\/sub>\/FiO2<\/sub>\u00a0\u4e3a 60 (54\u201368) mm Hg\u3002\u5f00\u59cbECMO\u6cbb\u7597\u540e60\u5929\uff0c\u4f30\u6d4b\u5728\u6bcf\u79cd\u72b6\u6001\u7684\u6982\u7387\u5206\u522b\u662f\u72b6\u60011\u4e3a 6% (95% CI 3\u201314)\uff0c\u72b6\u60012\u4e3a18% (11\u201328)\uff0c\u72b6\u60013\u4e3a 45% (35\u201356)\uff0c\u72b6\u60014\u4e3a 31% (22\u201342)\u300235\u540d (42%) \u60a3\u8005\u6709\u5927\u51fa\u8840\uff0c4\u540d\u60a3\u8005 (5%) \u53d1\u751f\u51fa\u8840\u6027\u5352\u4e2d\u300230\u540d\u60a3\u8005\u6b7b\u4ea1\u3002<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

Interpretation \u7ed3\u8bba<\/h3>\n\n\n\n

The estimated 60-day survival of ECMO-rescued patients with COVID-19 was similar to that of studies published in the past 2 years on ECMO for severe ARDS. If another COVID-19 outbreak occurs, ECMO should be considered for patients developing refractory respiratory failure despite optimised care.<\/p>\n\n\n\n

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Funding \u8d44\u52a9<\/h3>\n\n\n\n

None.<\/p>\n","protected":false},"excerpt":{"rendered":"

Extracorporeal membrane oxygenation for severe acute re […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/19249"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=19249"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/19249\/revisions"}],"predecessor-version":[{"id":19250,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/19249\/revisions\/19250"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=19249"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=19249"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=19249"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}