{"id":19067,"date":"2020-06-25T04:48:30","date_gmt":"2020-06-24T20:48:30","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=19067"},"modified":"2020-07-14T16:12:54","modified_gmt":"2020-07-14T08:12:54","slug":"recovery%e7%a0%94%e7%a9%b6%e5%88%9d%e6%ad%a5%e7%bb%93%e6%9e%9c%e9%a2%84%e5%8f%91%e8%a1%a8%ef%bc%9a%e5%9c%b0%e5%a1%9e%e7%b1%b3%e6%9d%be%e5%af%b9%e6%96%b0%e5%86%a0%e6%84%9f%e6%9f%93%e4%bd%8f%e9%99%a2","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=19067","title":{"rendered":"[RECOVERY\u7814\u7a76\u521d\u6b65\u7ed3\u679c\u9884\u53d1\u8868]\uff1a\u5730\u585e\u7c73\u677e\u5bf9\u65b0\u51a0\u611f\u67d3\u4f4f\u9662\u60a3\u8005\u7684\u5f71\u54cd\u2014\u521d\u6b65\u62a5\u544a"},"content":{"rendered":"\n

Effect of Dexamethasone in Hospitalized Patients with COVID-19 \u2013 Preliminary Report<\/h1>\n\n\n\n

RECOVERY Collaborative Group<\/h3>\n\n\n\n

ABSTRACT<\/h2>\n\n\n\n

Background:<\/h3>\n\n\n\n

Coronavirus disease 2019 (COVID-19) is associated with diffuse lung damage. Corticosteroids may modulate immune-mediated lung injury and reducing progression to respiratory failure and death.<\/p>\n\n\n\n

Methods:<\/h3>\n\n\n\n

The Randomised Evaluation of COVID-19 therapy (RECOVERY) trial is a randomized, controlled, open-label, adaptive, platform trial comparing a range of possible treatments with usual care in patients hospitalized with COVID-19. We report the preliminary results for the comparison of dexamethasone 6 mg given once daily for up to ten days vs. usual care alone. The primary outcome was 28-day mortality.<\/p>\n\n\n\n

Results:<\/h3>\n\n\n\n

2104 patients randomly allocated to receive dexamethasone were compared with 4321 patients concurrently allocated to usual care. Overall, 454 (21.6%) patients allocated dexamethasone and 1065 (24.6%) patients allocated usual care died within 28 days (ageadjusted rate ratio [RR] 0.83; 95% confidence interval [CI] 0.74 to 0.92; P<0.001). The proportional and absolute mortality rate reductions varied significantly depending on level of respiratory support at randomization (test for trend p<0.001): Dexamethasone reduced deaths by one-third in patients receiving invasive mechanical ventilation (29.0% vs. 40.7%, RR 0.65 [95% CI 0.51 to 0.82]; p<0.001), by one-fifth in patients receiving oxygen without invasive mechanical ventilation (21.5% vs. 25.0%, RR 0.80 [95% CI 0.70 to 0.92]; p=0.002), but did not reduce mortality in patients not receiving respiratory support at randomization (17.0% vs. 13.2%, RR 1.22 [95% CI 0.93 to 1.61]; p=0.14).<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
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Conclusions:<\/h3>\n\n\n\n

In patients hospitalized with COVID-19, dexamethasone reduced 28-day mortality among those receiving invasive mechanical ventilation or oxygen at randomization, but not among patients not receiving respiratory support.<\/p>\n\n\n\n

Trial registrations:<\/h3>\n\n\n\n

The RECOVERY trial is registered with ISRCTN (50189673) and clinicaltrials.gov (NCT04381936).<\/p>\n\n\n\n

Funding:<\/h3>\n\n\n\n

Medical Research Council and National Institute for Health Research (Grant ref: MC_PC_19056).<\/p>\n","protected":false},"excerpt":{"rendered":"

Effect of Dexamethasone in Hospitalized Patients with C […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/19067"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=19067"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/19067\/revisions"}],"predecessor-version":[{"id":19072,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/19067\/revisions\/19072"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=19067"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=19067"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=19067"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}