{"id":18912,"date":"2020-05-21T05:30:26","date_gmt":"2020-05-20T21:30:26","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=18912"},"modified":"2020-07-14T16:15:49","modified_gmt":"2020-07-14T08:15:49","slug":"lancet%e4%b8%b4%e5%ba%8a%e7%97%85%e4%be%8b%ef%bc%9a%e6%96%b0%e5%86%a0%e7%97%85%e6%af%92%e6%84%9f%e6%9f%93%e6%82%a3%e8%80%85%e7%9a%84%e5%bf%83%e8%82%8c%e7%82%8e%ef%bc%9a%e8%82%8c%e9%92%99%e8%9b%8b","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=18912","title":{"rendered":"[Lancet\u4e34\u5e8a\u75c5\u4f8b]\uff1a\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u60a3\u8005\u7684\u5fc3\u808c\u708e\uff1a\u808c\u9499\u86cb\u767d\u5347\u9ad8\u548c\u5fc3\u7535\u56fe\u6539\u53d8\u7684\u539f\u56e0"},"content":{"rendered":"\n

CLINICAL PICTURE|\u00a0VOLUME 395, ISSUE 10235<\/a>,\u00a0P1516,\u00a0MAY 09, 2020<\/p>\n\n\n\n

Myocarditis in a patient with COVID-19: a cause of raised troponin and ECG changes<\/h1>\n\n\n\n

Denis Doyen, Pamela Moceri, Doroth\u00e9e Ducreux, et al<\/h3>\n\n\n\n

Lancet 2020; 395: 1516<\/h3>\n\n\n\n

A 69-year old man, from Lombardy, Italy, was admitted to our unit because of acute respiratory distress syndrome that required mechanical ventilation; he was in Nice, France, on holiday. He had previously been fit and well; he had a history of hypertension controlled with bisoprolol 2\u00b75 mg\/day. He initially reported vomiting and diarrhoea, and 7 days afterwards, he came to our emergency department with a cough, fever of 39\u00b0C, and dyspnoea. He was immediately transferred to our intensive care unit (ICU) because of the respiratory distress syndrome and severe hypoxia. Investigations found a haemoglobin concentration of 15\u00b74 g\/dL, a platelet count of 187\u2008\u00d7\u2008109<\/sup>\u00a0per L, and a leucocyte count of 14\u00b79\u2008\u00d7\u2008109<\/sup>\u00a0per L (neutrophils 89%, lymphocytes 7%, monocytes 4%, and no eosinophils or basophils 0%). His blood pH was 7\u00b727, partial pressure of carbon dioxide was 45\u00b73 mm Hg, partial pressure of oxygen was 146 mm Hg, and peripheral oxygen saturation was 98\u00b72%.<\/p>\n\n\n\n

A CT of his chest showed bilateral ground-glass opacities and condensations (figure<\/a>;\u00a0video<\/a>). PCR of swabs taken from his upper respiratory tract showed severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) confirming a diagnosis of coronavirus disease 19 (COVID-19). Multiplex PCR was negative for other viruses using BioFire FilmArray Respiratory Panel 2 plus (bioM\u00e9rieux, Marcy l'Etoile, France) and no bacterial infections were found. An electrocardiogram (ECG), done on admission to the ICU, showed signs of left ventricular hypertrophy (LVH) and diffuse inverted T waves (figure<\/a>)\u2014a previous ECG showed inverted T waves in anterior leads only. High-sensitivity cardiac troponin I concentration was raised at 9002 ng\/L (normal <40). Transthoracic echocardiography showed mild LVH; the left ventricular ejection fraction and wall motion were within normal limits (figure<\/a>;\u00a0video<\/a>). The patient was known to have LVH which was probably caused by his chronic hypertension.<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n

Antiplatelet therapy\u2014aspirin\u2014and anticoagulation therapy\u2014fondaparinux\u2014were started because we suspected a non-ST elevation myocardial infarction: his Global Registry of Acute Coronary Events (GRACE) score was greater than 140. However, coronary angiography showed no disease, but cardiovascular magnetic resonance scanning showed subepicardial late gadolinium enhancement of the apex and inferolateral wall\u2014suggestive of myocarditis (figure<\/a>;\u00a0video<\/a>). We decided not to do an endomyocardial biopsy because the patient showed no signs of heart failure or arrhythmias. Additional tests for common causes of myocarditis\u2014including parvovirus B19, human herpes virus, Epstein-Barr virus, enterovirus, cytomegalovirus, adenovirus, HIV, and hepatitis C virus\u2014were negative. We therefore concluded that SARS-CoV-2 infection was the most likely cause of our patient's myocarditis. We gave the patient hydrocortisone at day 11 for 9 days with the aim of reducing inflammation\u2014particularly of the myocardium. The patient was weaned off mechanical ventilation and discharged from the ICU after 3 weeks.<\/p>\n\n\n\n

We believe this comprehensive description of myocarditis associated with COVID-19 confirms the importance of recent data reporting acute cardiac injury in almost a fifth of patients, with a 50% survival rate. It is recommended that troponin is not routinely measured in patients with COVID-19. However, physicians need to pay heed to the possibility of myocarditis in cases of COVID-19: in cases with high GRACE scores and dynamic ECG changes, usual guidelines to exclude the possibility of an acute myocardial infarction, including measuring troponin and doing an angiogram within 24 h, need to be followed (video<\/a>).<\/p>\n","protected":false},"excerpt":{"rendered":"

CLINICAL PICTURE|\u00a0VOLUME 395, ISSUE 10235,\u00a0P1516,\u00a0MAY 0 […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[16,13],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/18912"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=18912"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/18912\/revisions"}],"predecessor-version":[{"id":18913,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/18912\/revisions\/18913"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=18912"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=18912"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=18912"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}