{"id":18769,"date":"2020-03-26T04:02:00","date_gmt":"2020-03-25T20:02:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=18769"},"modified":"2020-07-14T16:20:14","modified_gmt":"2020-07-14T08:20:14","slug":"%e4%b8%ad%e5%92%8c%e7%99%bd%e4%bb%8b%e7%b4%a0-17a%e5%87%8f%e5%b0%91%e4%bf%83%e7%82%8e%e5%9b%a0%e5%ad%90%e4%bb%a5%e5%87%8f%e8%bd%bb%e7%83%a7%e4%bc%a4%e5%90%8e%e8%82%a0%e7%b2%98%e8%86%9c%e6%8d%9f","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=18769","title":{"rendered":"\u4e2d\u548c\u767d\u4ecb\u7d20-17A\u51cf\u5c11\u4fc3\u708e\u56e0\u5b50\u4ee5\u51cf\u8f7b\u70e7\u4f24\u540e\u80a0\u7c98\u819c\u635f\u5bb3"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\">Research Article: Neutralization of interleukin-17A alleviates burn-induced intestinal barrier disruption via reducing pro-inflammatory cytokines in a mouse model<\/h3>\n\n\n\n<h3 class=\"wp-block-heading\">How to cite: Song Y, Li Y, Xiao Y, Hu W, Wang X, Wang P, et al. Burns Trauma.2019; 7:37.<\/h3>\n\n\n\n<p>\u70e7\u4f24\u540e\u80a0\u7c98\u819c\u5c4f\u969c\u53d7\u635f\u53ef\u80fd\u7531\u591a\u79cd\u673a\u5236\u5171\u540c\u4f5c\u7528\uff0c\u5176\u4e2d\uff0c\u5c40\u90e8\u53ca\u5168\u8eab\u708e\u75c7\u53cd\u5e94\u7684\u53c2\u4e0e\u662f\u80a0\u7c98\u819c\u5c4f\u969c\u529f\u80fd\u53d7\u635f\u7684\u91cd\u8981\u56e0\u7d20\u3002\u56e0\u6b64\uff0c\u5982\u4f55\u5728\u70e7\u4f24\u65e9\u671f\u6709\u6548\u63a7\u5236\u708e\u75c7\u7684\u53d1\u751f\u3001\u53d1\u5c55\uff0c\u662f\u4fdd\u62a4\u80a0\u7c98\u819c\uff0c\u51cf\u5c11\u5e76\u53d1\u75c7\uff0c\u6539\u5584\u9884\u540e\u7684\u91cd\u8981\u56e0\u7d20\u3002\u5728\u591a\u79cd\u708e\u75c7\u75be\u75c5\u6a21\u578b\u4e2d\uff0c\u767d\u4ecb\u7d20-17A\u901a\u8fc7\u8bf1\u5bfc\u4e2d\u6027\u7c92\u7ec6\u80de\u548c\u8c03\u8282\u5176\u4ed6\u708e\u6027\u7ec6\u80de\u7b49\u9014\u5f84\u53d1\u6325\u91cd\u8981\u7684\u4fc3\u708e\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u5728\u70e7\u4f24\u65e9\u671f\uff0c\u901a\u8fc7\u4e2d\u548c\u767d\u4ecb\u7d20-17A\uff0c\u6709\u6548\u63a7\u5236\u708e\u75c7\uff0c\u662f\u51cf\u5c11\u80a0\u7c98\u819c\u635f\u5bb3\u7684\u7b56\u7565\u4e4b\u4e00\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/csccm.org.cn\/wp-content\/uploads\/2020\/03\/\u56fe\u7247-1-2-845x1024.png\" alt=\"\" class=\"wp-image-18770\"\/><\/figure>\n\n\n\n<p>Fig. 1. Interleukin (IL)-17A neutralization attenuated intestinal pathological changes and zonula occludens-1 (ZO-1) alteration, suppressed intestinal permeability elevation, and inhibited increases of cytokines.<\/p>\n\n\n\n<p>\u9646\u519b\u519b\u533b\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u70e7\u4f24\u79d1\u8d3a\u4f1f\u5cf0\u6559\u6388\u8bfe\u9898\u7ec4\u957f\u671f\u4ece\u4e8b\u70e7\u4f24\u521b\u9762\u53ca\u79fb\u690d\u514d\u75ab\u7814\u7a76\uff0c\u6b64\u6b21\u8054\u5408\u9646\u519b\u519b\u533b\u5927\u5b66\u7b2c\u4e8c\u9644\u5c5e\u533b\u9662\u9ec4\u8d64\u5175\u6559\u6388\u79fb\u690d\u514d\u75ab\u8bfe\u9898\u7ec4\uff0c\u5171\u540c\u5728Burns &amp; Trauma\u00a0\u520a\u6587\u201cNeutralization of interleukin-17A alleviates burn-induced intestinal barrier disruption via reducing pro-inflammatory cytokines in a mouse model\u201d\uff0c\u4ecb\u7ecd\u4e86\u7528\u6297\u4f53\u4e2d\u548c\u767d\u4ecb\u7d20-17A\u5bf9\u70e7\u4f24\u540e\u5c0f\u9f20\u80a0\u7c98\u819c\u5c4f\u969c\u7684\u5f71\u54cd\u3002\u8be5\u7814\u7a76\u663e\u793a\uff1a\u901a\u8fc7\u8179\u8154\u6ce8\u5c04\u767d\u4ecb\u7d20-17A\u6297\u4f53\uff0c\u89c2\u5bdf\u5c0f\u9f20\u70eb\u4f24\u540e\u80a0\u7c98\u819c\u7684\u75c5\u7406\u6539\u53d8\uff0c\u80a0\u7c98\u819c\u901a\u900f\u6027\u548c\u80a0\u4e0a\u76ae\u95f4\u7d27\u5bc6\u94fe\u63a5\u86cb\u767d\u8868\u8fbe\u5dee\u5f02\uff0c\u4ee5\u53ca\u80a0\u9053\u5c40\u90e8\u548c\u5168\u8eab\u708e\u75c7\u56e0\u5b50\u8868\u8fbe\u53d8\u5316\u7b49\uff0c\u53d1\u73b0\u6297\u4f53\u4e2d\u548c\u767d\u4ecb\u7d20-17A\u53ef\u51cf\u8f7b\u80a0\u7c98\u819c\u7684\u75c5\u7406\u635f\u4f24\uff0c\u964d\u4f4e\u80a0\u7c98\u819c\u901a\u900f\u6027\uff0c\u6291\u5236\u7d27\u5bc6\u94fe\u63a5\u86cb\u767d\u8868\u8fbe\u4e0b\u964d\uff0c\u5e76\u4e14\u964d\u4f4eIL-6, IL-1\u03b2\u7b49\u708e\u75c7\u56e0\u5b50\u8868\u8fbe\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/csccm.org.cn\/wp-content\/uploads\/2020\/03\/\u56fe\u7247-2-1-756x1024.png\" alt=\"\" class=\"wp-image-18771\"\/><\/figure>\n\n\n\n<p>Fig. 2. Flow cytometry analysis of interleukin (IL)-17A expression in \u03b3\u03b4T cells isolated from intestinal epithelial lymphocytes (IELs). IEL cells were gated in the oval, and membrane staining with anti-mouse CD3, TCR\u03b3\u03b4, V\u03b34+ or V\u03b31+ antibody and intracellular staining with anti-mouse IL-17A antibody were performed.&nbsp;<\/p>\n\n\n\n<p>\u8be5\u6587\u7ae0\u8868\u660e\uff1a\u4e2d\u548c\u767d\u4ecb\u7d20-17A\u53ef\u6709\u6548\u51cf\u8f7b\u70e7\u4f24\u5f15\u53d1\u7684\u80a0\u7c98\u819c\u53d7\u635f\uff0c\u4fdd\u62a4\u80a0\u7c98\u819c\u5c4f\u969c\u529f\u80fd\u3002\u6b64\u5916\uff0c\u7814\u7a76\u8005\u8fd8\u521d\u6b65\u53d1\u73b0\uff0c\u70e7\u4f24\u540e\u65e9\u671f\u767d\u4ecb\u7d20-17A\u4e3b\u8981\u7531V\u03b34+&nbsp;\u8fd9\u4e00T\u6dcb\u5df4\u7ec6\u80de\u4e9a\u578b\u5206\u6ccc\uff0c\u4e3a\u8fdb\u4e00\u6b65\u6df1\u5165\u63a2\u7d22\u767d\u4ecb\u7d20-17A\u53caV\u03b34+T\u6dcb\u5df4\u7ec6\u80de\u5728\u70e7\u4f24\u540e\u80a0\u7c98\u819c\u635f\u4f24\u4e2d\u7684\u4f5c\u7528\u63d0\u4f9b\u7ebf\u7d22\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research Article: Neutralization of interleukin-17A all [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/18769"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=18769"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/18769\/revisions"}],"predecessor-version":[{"id":18772,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/18769\/revisions\/18772"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=18769"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=18769"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=18769"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}