{"id":18147,"date":"2019-12-29T05:46:21","date_gmt":"2019-12-28T21:46:21","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=18147"},"modified":"2020-01-02T05:40:54","modified_gmt":"2020-01-01T21:40:54","slug":"bmj%e5%9c%a3%e8%af%9e%e4%b8%93%e5%88%8a%ef%bc%9a%e7%be%8e%e5%9b%bd%e5%a5%b3%e6%80%a7%e5%87%ba%e7%94%9f%e6%9c%88%e4%bb%bd%e3%80%81%e5%87%ba%e7%94%9f%e5%ad%a3%e8%8a%82%e4%b8%8e%e6%80%bb%e6%ad%bb","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=18147","title":{"rendered":"[BMJ\u5723\u8bde\u4e13\u520a]\uff1a\u7f8e\u56fd\u5973\u6027\u51fa\u751f\u6708\u4efd\u3001\u51fa\u751f\u5b63\u8282\u4e0e\u603b\u6b7b\u4ea1\u7387\u548c\u5fc3\u8840\u7ba1\u75be\u75c5\u6b7b\u4ea1\u7387\u7684\u76f8\u5173\u6027\uff1a\u524d\u77bb\u961f\u5217\u7814\u7a76"},"content":{"rendered":"\n

Research<\/strong> Christmas 2019: Let it Be<\/p>\n\n\n\n

Birth month, birth season, and overall and cardiovascular disease mortality in US women: prospective cohort study<\/h1>\n\n\n\n

Yin Zhang, \u00a0Elizabeth E Devore, Susanne Strohmaier, et al<\/h3>\n\n\n\n

BMJ<\/em>\u00a02019;367:l6058\u00a0doi:\u00a0https:\/\/doi.org\/10.1136\/bmj.l6058<\/a>\u00a0(Published 18 December 2019)<\/h3>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Objectives<\/strong>\u00a0\u76ee\u7684<\/h3>\n\n\n\n

To evaluate the associations between birth month, birth season, and overall and cardiovascular disease mortality, and to examine the role of familial and socioeconomic factors in these associations.<\/p>\n\n\n\n

\u8bc4\u4ef7\u51fa\u751f\u6708\u4efd\u3001\u51fa\u751f\u5b63\u8282\u4e0e\u603b\u6b7b\u4ea1\u7387\u53ca\u5fc3\u8840\u7ba1\u75be\u75c5\u6b7b\u4ea1\u7387\u7684\u76f8\u5173\u6027\uff0c\u5e76\u7814\u7a76\u5bb6\u5ead\u4e0e\u793e\u4f1a\u7ecf\u6d4e\u56e0\u7d20\u5728\u4e0a\u8ff0\u76f8\u5173\u6027\u4e2d\u7684\u4f5c\u7528\u3002<\/p>\n\n\n\n

Design<\/strong>\u00a0\u8bd5\u9a8c\u8bbe\u8ba1<\/h3>\n\n\n\n

Prospective cohort study.<\/p>\n\n\n\n

\u524d\u77bb\u961f\u5217\u7814\u7a76<\/p>\n\n\n\n

Setting<\/strong>\u00a0\u573a\u666f<\/h3>\n\n\n\n

Nurses\u2019 Health Study, established in 1976, an ongoing prospective cohort study in the United States.<\/p>\n\n\n\n

\u59cb\u4e8e1976\u5e74\u7684\u62a4\u58eb\u5065\u5eb7\u7814\u7a76\u662f\u7f8e\u56fd\u4e00\u9879\u524d\u77bb\u6027\u961f\u5217\u7814\u7a76<\/p>\n\n\n\n

Participants<\/strong>\u00a0\u7814\u7a76\u5bf9\u8c61<\/h3>\n\n\n\n

Female registered nurses who reported information on date of birth at study enrolment (n=116\u2009911, 1976-2014, followed for 38 years).<\/p>\n\n\n\n

\u5728\u7eb3\u5165\u7814\u7a76\u65f6\u62a5\u544a\u51fa\u751f\u65e5\u671f\u7684\u5973\u6027\u6ce8\u518c\u62a4\u58eb (n=116\u2009911, 1976-2014, \u968f\u8bbf 38 \u5e74)\u3002<\/p>\n\n\n\n

Exposure<\/strong>\u00a0\u66b4\u9732\u56e0\u7d20<\/h3>\n\n\n\n

Birth month and astronomical birth season (based on solstices and equinoxes as boundaries of the season categories).<\/p>\n\n\n\n

\u51fa\u751f\u6708\u4efd\u4e0e\u5929\u6587\u51fa\u751f\u5b63\u8282\uff08\u6839\u636e\u5206\u81f3\u70b9\u533a\u5206\u5b63\u8282\uff09\u3002<\/p>\n\n\n\n

Main outcome measures<\/strong>\u00a0\u4e3b\u8981\u9884\u540e\u6307\u6807<\/h3>\n\n\n\n

Age and various multivariable adjusted hazard ratios and 95% confidence intervals for the association between birth months (using November as the reference), astronomical birth season (using autumn as the reference), and overall and cardiovascular disease specific mortality were assessed using Cox proportional hazards models.<\/p>\n\n\n\n

\u6839\u636e\u5e74\u9f84\u53ca\u591a\u79cd\u56e0\u7d20\u8fdb\u884c\u6821\u6b63\u540e\uff0c\u91c7\u7528Cox\u6bd4\u4f8b\u98ce\u9669\u6a21\u578b\u8ba1\u7b97\u51fa\u751f\u6708\u4efd (\u4ee511\u6708\u4f5c\u4e3a\u53c2\u7167)\u548c\u5929\u6587\u51fa\u751f\u5b63\u8282 (\u4ee5\u79cb\u5b63\u4f5c\u4e3a\u53c2\u7167)\u4e0e\u603b\u6b7b\u4ea1\u7387\u53ca\u5fc3\u8840\u7ba1\u75be\u75c5\u6b7b\u4ea1\u7387\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u3002<\/p>\n\n\n\n

Results<\/strong>\u00a0\u7ed3\u679c<\/h3>\n\n\n\n

Among study participants, 43\u2009248 overall deaths were documented during 4\u2009136\u2009364 person years of follow-up since enrolment, including 8360 cardiovascular disease related deaths. In fully adjusted multivariable analyses, no significant association was observed between birth month, birth season, and overall mortality. Compared with women born in November, increased cardiovascular disease mortality was observed among those born from March to July (hazard ratio for March, 1.09, 95% confidence interval 0.98 to 1.21; April, 1.12, 1.00 to 1.24; May, 1.08, 0.98 to 1.20; June, 1.07, 0.96 to 1.19; and July 1.08, 0.98 to 1.20). Those born in April had the highest cardiovascular disease mortality, and those born in December had the lowest (December, 0.95, 0.85 to 1.06). The relative difference between the lowest and highest risk month was 17.89%. Women born in spring (1.10, 1.04 to 1.17) and summer (1.09, 1.03 to 1.16) had a higher cardiovascular disease mortality than women born in the autumn. Adjustment for familial and socioeconomic factors did not change these results. The relative difference between the lowest and highest risk season was 10.00%.<\/p>\n\n\n\n

\u6240\u6709\u53c2\u7814\u5bf9\u8c61\u7eb3\u5165\u7814\u7a76\u540e\uff0c\u5728\u968f\u8bbf\u76844\u2009136\u2009364 \u4eba\u5e74\u95f4\uff0c\u5171\u670943\u2009248 \u4f8b\u6b7b\u4ea1\uff0c\u5176\u4e2d\u5305\u62ec 8360 \u4f8b\u5fc3\u8840\u7ba1\u76f8\u5173\u6b7b\u4ea1\u3002\u901a\u8fc7\u591a\u56e0\u7d20\u5206\u6790\u8fdb\u884c\u6821\u6b63\u540e\uff0c\u51fa\u751f\u6708\u4efd\u3001\u51fa\u751f\u5b63\u8282\u4e0e\u603b\u6b7b\u4ea1\u7387\u4e4b\u95f4\u65e0\u663e\u8457\u76f8\u5173\u6027\u3002\u4e0e11\u6708\u51fa\u751f\u7684\u5973\u6027\u76f8\u6bd4\uff0c3\u6708\u81f37\u6708\u51fa\u751f\u8005\u5fc3\u8840\u7ba1\u75be\u75c5\u6b7b\u4ea1\u7387\u589e\u52a0 (3\u6708\u4efd\u98ce\u9669\u6bd4, 1.09, 95% \u53ef\u4fe1\u533a\u95f4 0.98 to 1.21; 4\u6708\u4efd, 1.12, 1.00 to 1.24; 5\u6708\u4efd, 1.08, 0.98 to 1.20; 6\u6708\u4efd, 1.07, 0.96 to 1.19; \u548c7\u6708\u4efd 1.08, 0.98 to 1.20)\u30024\u6708\u51fa\u751f\u8005\u5fc3\u8840\u7ba1\u75be\u75c5\u6b7b\u4ea1\u7387\u6700\u9ad8\uff0c12\u6708\u51fa\u751f\u8005\u6700\u4f4e (12\u6708\u4efd, 0.95, 0.85 to 1.06)\u3002\u98ce\u9669\u6700\u4f4e\u4e0e\u6700\u9ad8\u6708\u4efd\u76f8\u5bf9\u5dee\u5f02\u4e3a 17.89%\u3002\u6625\u5b63(1.10, 1.04 to 1.17) \u548c\u590f\u5b63(1.09, 1.03 to 1.16)\u51fa\u751f\u7684\u5973\u6027\u5fc3\u8840\u7ba1\u75be\u75c5\u6b7b\u4ea1\u7387\u9ad8\u4e8e\u79cb\u5b63\u51fa\u751f\u8005\u3002\u5bf9\u5bb6\u5ead\u53ca\u793e\u4f1a\u7ecf\u6d4e\u56e0\u7d20\u8fdb\u884c\u6821\u6b63\uff0c\u5e76\u4e0d\u6539\u5584\u4e0a\u8ff0\u7ed3\u679c\u3002\u98ce\u9669\u6700\u4f4e\u4e0e\u6700\u9ad8\u5b63\u8282\u7684\u76f8\u5bf9\u5dee\u5f02\u4e3a 10.00%\u3002<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n

Conclusion<\/strong>\u00a0\u7ed3\u8bba<\/h3>\n\n\n\n

Participants born in the spring and summer (especially those born in March-July) had a slight but significant increase in cardiovascular disease specific mortality. However, no seasonal birth month effect was observed among women for overall mortality. Familial and socioeconomic factors did not appear to alter these associations. Further studies are required to confirm these findings and reveal mechanisms of these seasonal birth month effects in cardiovascular disease mortality.<\/p>\n\n\n\n

\u6625\u5b63\u4e0e\u590f\u5b63\u51fa\u751f\u8005\uff08\u7279\u522b\u662f3\u6708\u81f37\u6708\u51fa\u751f\u8005\uff09\u5fc3\u8840\u7ba1\u75be\u75c5\u6b7b\u4ea1\u7387\u8f7b\u5ea6\u4e14\u663e\u8457\u589e\u52a0\u3002\u7136\u800c\uff0c\u5973\u6027\u51fa\u751f\u5b63\u8282\u548c\u6708\u4efd\u4e0e\u603b\u6b7b\u4ea1\u7387\u6ca1\u6709\u76f8\u5173\u6027\u3002\u5bb6\u5ead\u4e0e\u793e\u4f1a\u7ecf\u6d4e\u56e0\u7d20\u5e76\u4e0d\u6539\u53d8\u4e0a\u8ff0\u76f8\u5173\u6027\u3002\u9700\u8981\u8fdb\u4e00\u6b65\u7814\u7a76\u786e\u5b9a\u8fd9\u4e00\u7ed3\u679c\uff0c\u5e76\u63ed\u793a\u51fa\u751f\u5b63\u8282\u4e0e\u6708\u4efd\u5bf9\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u7387\u4ea7\u751f\u5f71\u54cd\u7684\u673a\u5236\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

Research Christmas 2019: Let it Be Birth month, bi […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/18147"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=18147"}],"version-history":[{"count":2,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/18147\/revisions"}],"predecessor-version":[{"id":18149,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/18147\/revisions\/18149"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=18147"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=18147"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=18147"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}