{"id":17794,"date":"2019-11-04T05:43:58","date_gmt":"2019-11-03T21:43:58","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=17794"},"modified":"2019-12-12T07:12:30","modified_gmt":"2019-12-11T23:12:30","slug":"icu-management-practice-%e6%96%b0%e7%94%9f%e5%84%bf%e6%97%a9%e5%8f%91%e6%80%a7%e8%84%93%e6%af%92%e7%97%87%e8%ae%a1%e7%ae%97%e5%99%a8","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=17794","title":{"rendered":"[ICU Management &#038; Practice] \u65b0\u751f\u513f\u65e9\u53d1\u6027\u8113\u6bd2\u75c7\u8ba1\u7b97\u5668"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\" id=\"name\">Neonatal Early-Onset Sepsis Calculator<\/h1>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/healthmanagement.org\/uploads\/from_cloud\/cw\/00115531_cw_image_wi_85ca958c312c96ea96e4e2a1b069ba4b.jpg\" alt=\"\"\/><\/figure>\n\n\n\n<p>In 2007, a study funded by the National Institutes of Health assessed the use of predictive models to calculate the risk of early-onset sepsis (EOS) in neonatal patients, accounting for multiple variables.\u00a0The main objectives of the study were to assess the links between the risk factors and the infection outcomes; use patient data collected from electronic medical records; and, to generate a predictive model to accurately determine EOS likelihood without using the patient\u2019s diagnosis of chorioamnionitis as an indicator.\u00a0Researchers were able to develop models based on the risk factors determined at birth and also the patient\u2019s developing clinical condition with a clinical management algorithm. Both of these models were published. The management algorithm was developed in collaboration with clinicians who had worked in Kaiser-Permanente Northern California (KPNC). The algorithm assessed the estimated risk with the number-needed-to-treat (average number of patients that need to be treated to prevent one bad outcome).\u00a0The outcome of the study was the generation of a neonatal EOS calculator, a web-based tool to help clinicians with diagnosis and treatment of EOS. This was implemented in KPNC hospitals with reassessments throughout the programme.\u00a0Two validation studies, a large study conducted at KPNC birth hospitals and a smaller one in Philadelphia, were used to confirm the accuracy of the calculator. Despite the slight differences in the clinical management algorithms in the validation studies, both showed significant decreases in infant antibiotic use with no short-term safety issues identified. The low readmission incidences for EOS in newborns was also maintained in both cases.\u00a0The success of the neonatal EOS calculator has since been confirmed by other studies, showing that this approach has led to a decreased use of antibiotics whilst also able to successfully identify newborns with EOS.<\/p>\n\n\n\n<p>Source:\u00a0<a rel=\"noreferrer noopener\" href=\"https:\/\/jamanetwork.com\/journals\/jamapediatrics\/article-abstract\/2748687\" target=\"_blank\">JAMA Pediatrics<\/a><\/p>\n\n\n\n<p>Image Credit:\u00a0<a rel=\"noreferrer noopener\" href=\"https:\/\/www.istockphoto.com\/photo\/the-diagnosis-sepsis-written-on-a-clipboard-gm893472936-247149072\" target=\"_blank\">iStock<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">References:<\/h4>\n\n\n\n<p>Puopolo KM &amp;&nbsp;Escobar GJ (2019) Neonatal Sepsis Evaluation:&nbsp;Facing the Certainty of Uncertainty.&nbsp;<em>JAMA Pediatr,&nbsp;<\/em>Published online September 03, 2019.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Neonatal Early-Onset Sepsis Calculator In 2007, a study [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[24,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/17794"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17794"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/17794\/revisions"}],"predecessor-version":[{"id":17795,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/17794\/revisions\/17795"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17794"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=17794"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=17794"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}