{"id":17674,"date":"2019-11-28T04:00:39","date_gmt":"2019-11-27T20:00:39","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=17674"},"modified":"2019-12-12T07:10:25","modified_gmt":"2019-12-11T23:10:25","slug":"icu-management-practice-%e9%a2%85%e8%84%91%e5%88%9b%e4%bc%a4%e5%84%bf%e7%ab%a5%e5%91%bc%e6%b0%94%e6%9c%abco2%e4%b8%8e%e5%8a%a8%e8%84%89co2%e6%b0%b4%e5%b9%b3","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=17674","title":{"rendered":"[ICU Management & Practice]: \u9885\u8111\u521b\u4f24\u513f\u7ae5\u547c\u6c14\u672bCO2\u4e0e\u52a8\u8109CO2\u6c34\u5e73"},"content":{"rendered":"\n

End-Tidal CO2 Levels vs. Arterial CO2 Levels in Children with TBI<\/h1>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

For patients with Traumatic Brain Injury (TBI), the partial pressure of CO2<\/sub>, arterial (PaCO2<\/sub>) can be adjusted to help with the regulation of cerebral perfusion. However, this can prove difficult to carry out in children. The non-invasive method of capnography measures end-tidal CO2<\/sub>\u00a0(EtCO2<\/sub>) and is often used for paediatric patients as an alternative to arterial cannulation.<\/p>\n\n\n\n

EtCO2<\/sub>\u00a0measurements have previously been used to predict PaCO2<\/sub>\u00a0levels in adults but as such, no major clinical evidence is available to confirm or deny the accuracy of this method in paediatric patients with TBI.\u00a0The Brain Trauma Foundation has published guidelines that recommend avoidance of prophylactic hyperventilation and PaCO2<\/sub>\u00a0less than 30mm Hg in the initial 48 hours after submission. But there is no recommendation either for or against the use of EtCO2<\/sub>.\u00a0This study was conducted to evaluate the validity of using EtCO2<\/sub>\u00a0as an indicator of PaCO2<\/sub>\u00a0in children and adolescents. Using secondary analysis, researchers explored the agreements of PaCO2<\/sub>-EtCO2<\/sub>\u00a0measurements in 137 patients in the PICU.<\/p>\n\n\n\n

Study findings show that less than 50% of the PaCO2<\/sub>-EtCO2<\/sub>\u00a0pairs were in agreement, with only moderate correlation in the first 24 hours. Results suggest\u00a0that PaCO2<\/sub>-EtCO2<\/sub>\u00a0substitutions may be even more unreliable within the first 8 hours of admission, as the differences in PaCO2<\/sub>-EtCO2<\/sub>\u00a0were largest during this period.<\/p>\n\n\n\n

Findings also show that the presence of Paediatric Acute Respiratory Distress Syndrome (PARDS) in the first 24 hours of admission to the PICU was associated with a lower likelihood of PaCO2<\/sub>-EtCO2<\/sub>\u00a0agreement.\u00a0On average, PaCO2<\/sub>\u00a0was 9.9mm Hg higher than its paired EtCO2<\/sub>\u00a0value in patients who developed PARDS within the first 24 hours of admission. The median PaCO2<\/sub>-EtCO2<\/sub>\u00a0differences were found to be higher overall with those that developed PARDS in the week after TBI, compared to those who did not develop PARDS. However, more research is needed for the use of PaCO2<\/sub>-EtCO2<\/sub>\u00a0differences in indicating PARDS occurrence.<\/p>\n\n\n\n

Based on these results, EtCO2<\/sub>\u00a0should not be substituted for PaCO2<\/sub>\u00a0measurements in paediatric patients. Researchers recommended that PaCO2<\/sub>\u00a0should be used when monitoring CO2<\/sub>\u00a0levels in the first 24 hours after TBI.<\/p>\n\n\n\n

Source:\u00a0JAMA Network Open<\/a><\/p>\n\n\n\n

Image Credit:\u00a0iStock<\/a><\/p>\n\n\n\n

References:<\/h4>\n\n\n\n

Yang JT et al. (2019) Agreement Between Arterial Carbon Dioxide Levels With End-Tidal Carbon Dioxide Levels and Associated Factors in Children Hospitalized With Traumatic Brain Injury.<\/a> JAMA Netw Open 2(8):e199448.<\/p>\n","protected":false},"excerpt":{"rendered":"

End-Tidal CO2 Levels vs. Arterial CO2 Levels in Childre […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[24,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/17674"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17674"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/17674\/revisions"}],"predecessor-version":[{"id":17675,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/17674\/revisions\/17675"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17674"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=17674"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=17674"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}