ONLINE FIRST (FREE ACCESS) PHYSIOLOGY IN CRITICAL ILLNESS OPEN ACCESS ~ Understanding the Disease Fever dreams: demons and nightmares in an ICU bedMart, M.F., Shehabi, Y. STANDARD OF CARE IN INTENSIVE CARE What's New in Intensive Care Peripheral muscle ultrasound in the ICU: current evidence, limitations, and future directionsBald, A., Daum, N. & Schaller, S.J. LATEST ARTICLES Original Short-term light sedation with remimazolam besylate vers...

ORIGINAL ARTICLE Sodium Bicarbonate for Critically Ill Adults with Metabolic Acidosis and Shock The SODa-BIC Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group N Engl J Med Published June 12, 2026 DOI: 10.1056/NEJMoa2600526 Abstract BACKGROUND Metabolic acidosis is common in critically ill patients and is associated with organ dysfunction and death. Sodium bicarbonate is used to correct acidemia, but its bene...

Original Investigation  Critical Care Medicine Remote Monitoring Approaches to Reduce Readmissions After Infection and Sepsis: A Randomized Clinical Trial Sachin Yende, Victor B. Talisa, Kristin Mayes, et al JAMA Netw Open 2026;9;(6):e2616641. doi:10.1001/jamanetworkopen.2026.16641 Key Points Question  Does remote monitoring help individuals remain at home following hospitalization for serious infections?...

ORIGINAL ARTICLE Carbocisteine or Hypertonic Saline for Acute Respiratory Failure Bronwen Connolly, Naomi Dickson, Christina Campbell, et al N Engl J Med Published June 10, 2026 DOI: 10.1056/NEJMoa2603406 Abstract BACKGROUND Mucoactive agents are widely used in patients with acute respiratory failure despite limited evidence of their effectiveness or safety. METHODS We conducted a multicenter, open-label, randomized trial with a 2-by-2 factorial...

ORIGINAL ARTICLE Vasopressors or Fluids in Early Septic Shock The ARISE FLUIDS Investigators, the ANZICS Clinical Trials Group, and the ACEM Clinical Trials Network N Engl J Med Published June 11, 2026 DOI: 10.1056/NEJMoa2516225 Abstract BACKGROUND The optimal approach to early resuscitation in septic shock is unknown. Equipoise exists between the use of larger volumes of intravenous fluids to restore perfusion and the use of early vasopressor therapy...

Article Short-term light sedation with remimazolam besylate versus propofol in the ICU (SHOSREB): a multicentre, randomized, single-blind, controlled trial Yang, X., Pan, J., Gong, X. et al. Intensive Care Med (2026). https://doi.org/10.1007/s00134-026-08381-x Abstract Purpose To explore the efficacy and safety of remimazolam besylate in short-term sedation in the ICU in comparison with propofol. Method A multicenter, randomized, single-blind, non-...

Original Investigation  Caring for the Critically Ill Patient Sodium Bicarbonate for In-Hospital Cardiac Arrest: A Randomized Clinical Trial Asger Granfeldt, Bertram Lahn Kirkegaard, Mikael Fink Vallentin, et al JAMA Published Online: June 11, 2026 doi: 10.1001/jama.2026.10628 Key Points Question  Does sodium bicarbonate administered during in-hospital cardiac arrest improve return of spontaneous circulation? Findings  In t...

ORIGINAL ARTICLE Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism Kenneth Rosenfield, Frederikus A. Klok, Gregory Piazza, et al N Engl J Med Published March 28, 2026 DOI: 10.1056/NEJMoa2516567 Abstract BACKGROUND Whether anticoagulation alone is an adequate treatment for acute, intermediate-risk pulmonary embolism is uncertain. METHODS We conducted a multinational, adaptive-design trial with blinded outcome adj...

Original Investigation  Aging and Health Prompt and Intensive Antiviral Chemoprophylaxis in Nursing Home Influenza Outbreaks Joe B. B. Silva, Han-Chih T. Hsieh, Chanelle J. Howe, et al JAMA Intern Med Published Online: March 30, 2026 doi: 10.1001/jamainternmed.2026.0401 Key Points Question  Is initiation of antiviral chemoprophylaxis with oseltamivir for 70% or more of eligible nursing home (...

Original Investigation  Caring for the Critically Ill Patient High-Dose Intravenous Vitamin C and Mortality and Organ Dysfunction in Severe Burn Injury: The VICTORY Randomized Clinical Trial Christian Stoppe, Aileen Hill, Leopoldo C. Cancio, et al JAMA Published Online: June 10, 2026 doi: 10.1001/jama.2026.10616 Key Points Question  Does high-dose intravenous vitamin C reduce a composite of 28-day mortality and persistent organ dysfunct...