Weaning from VV-ECMO: Data from ESICM-Endorsed WEAN-ECMO Survey In ICU Thu, 15 Jan 2026 The use of venovenous extracorporeal membrane oxygenation (VV ECMO) for severe acute respiratory distress syndrome (ARDS) has risen substantially, and current guidelines recommend VV ECMO in selected patients to maintain adequate gas exchange while limiting ventilator-induced lung injury. Despite this, several critical components of ECMO management remain poorly sta...

Original Investigation  Caring for the Critically Ill Patient Respiratory Gas Shifts to Delay Asphyxiation in Critical Avalanche Burial: A Randomized Clinical Trial Frederik Eisendle, Giulia Roveri, Simon Rauch, et al JAMA 2025;334;(19):1720-1727 doi:10.1001/jama.2025.16837 Key Points Question  Does a novel device delay the onset of hypoxemia and hypercapnia during critical avalanche burial by enhancing air...

Invited Commentary  Pediatrics Respiratory Management of Neonatal Acute Respiratory Distress Syndrome Lucy Loft, David G. Tingay JAMA Netw Open 2026;9;(3):e260220. doi:10.1001/jamanetworkopen.2026.0220 High frequency oscillatory ventilation (HFOV) has been used to treat respiratory failure in neonates since the early 1990s.1 HFOV supports gas exchange by delivering very low tidal volumes at fast rates (>2 Hz). Theoretically, these characteristics of HF...

Original Investigation  Whole-Blood vs Component Therapy in Adult Trauma: An Updated Systematic Review and Meta-Analysis Wesam Ibrahim, Kenneth Meza Monge, Johannes Menzel, et al JAMA Surg Published Online: March 11, 2026 doi: 10.1001/jamasurg.2026.0197 Key Points Question  Is whole-blood transfusion associated with reduced mortality compared with component therapy in adult trauma patients? F...

Research Letter  Health Policy Early Morning Blood Draw Timing and Frequency Among Hospitalized Patients Michael Colacci, Anne Loffler, Surain B. Roberts, et al JAMA Netw Open 2026;9;(3):e260966. doi:10.1001/jamanetworkopen.2026.0966 Introduction Hospitalized patients report less sleep in the hospital and an increased number of nocturnal awakenings, which has been associated with the development of delirium.1,2&nbs...

Antibiotic De-Escalation in Patients Hospitalised With Community-Onset Sepsis Sepsis is a critical medical emergency that requires prompt treatment with broad-spectrum antibiotics (BSAs) to cover potential multidrug-resistant organisms (MDROs). While early empiric BSA therapy has been associated with reduced mortality in high-risk patients and is recommended by the 2021 Surviving Sepsis Campaign Guidelines, prolonged exposure to these agents carries significant ris...

Original Investigation  Pediatrics Smartphone Use During School Hours and Association With Cognitive Control in Youths Aged 11 to 18 Years Eva H. Telzer, Kaitlyn Burnell JAMA Netw Open 2026;9;(3):e261092. doi:10.1001/jamanetworkopen.2026.1092 Key Points Questions  How much are youths using their smartphones during school instruction time, and what is the association of this use with cognitive control? Findings &...

Invited Commentary  Cardiology Preventing ARDS, Not Treating It—Lessons From Sivelestat After Cardiopulmonary Bypass Warren L. Lee, Arthur S. Slutsky JAMA Netw Open 2026;9;(3):e261201. doi:10.1001/jamanetworkopen.2026.1201 Pan and colleagues1 report the findings of a large, blinded, placebo-controlled single-center randomized clinical trial of sivelestat for the prevention of acute respiratory distress syndrome (ARDS) among pat...

Original Investigation  Pediatrics High-Frequency Oscillation vs Mechanical Ventilation for Neonatal Acute Respiratory Distress Syndrome: A Randomized Clinical Trial Jie Li, Kaizhen Liu, Qian Yang, et al JAMA Netw Open 2026;9;(3):e260268. doi:10.1001/jamanetworkopen.2026.0268 Key Points Question  Does elective high-frequency oscillatory ventilation (HFOV) reduce the incidence of bronchopulmonary dysplasia...

Blood Biomarkers for Prediction of Outcome After Cardiac Arrest A study published in The Lancet Respiratory Medicine has identified neurofilament light (NFL) as the most accurate blood biomarker for predicting long-term neurological outcomes in patients who remain unconscious following cardiac arrest. This research, conducted within the Targeted Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial, represents the largest prospective int...