Original Investigation  Statistics and Research Methods Sex and All-Cause Mortality in the US, 1999 to 2019 Julia Francis, Barry I. Graubard, Hormuzd Katki, et al JAMA Netw Open 2026;9;(1):e2556299. doi:10.1001/jamanetworkopen.2025.56299 Key Points Question  Are there differences in mortality rates between males and females for all-cause mortality and the leading 9 causes of mortality? Findings &n...

FEATURE ARTICLE Determination of Adult Critical Care Physician Core Knowledge and Skills: Results of a Multidisciplinary, Modified Delphi Process Tisherman, Samuel A; Spevetz, Antoinette; Farmer, J. Christopher, et al Critical Care Medicine 54(2):p 224-233, February 2026. | DOI: 10.1097/CCM.0000000000006978 Abstract Objectives:  In the United States, training for physicians who manage critically ill adult patients (intensivists) evolved through para...

Update on ESICM Transfusion Guidelines In ICU Wed, 29 Oct 2025 At #LIVES2025, Nicole Juffermans, Professor of Translational Intensive Care Medicine at the University of Amsterdam Faculty of Medicine, provided an update on ESICM transfusion guidelines. While transition guidelines from 2020 and 2021 provided recommendations for transfusion practices, the perioperative setting has remained largely without updates. However, recent large trials have...

Articles Medical oxygen and respiratory support requirements for patients hospitalised with COVID-19 in 23 low-income and middle-income countries: a prospective, observational cohort study Pryanka Relan, Jamie Rylance, Yaseen M Arabi, et al Lancet Global Health 2026; 14; e233-e241 Summary Background The COVID-19 pandemic highlighted a global shortage of, and inequity of access to, medical oxygen. Understanding patient outcomes an...

Articles Trends in mortality due to haemophagocytic lymphohistiocytosis across 29 European countries from 2011 to 2021: a retrospective, international, population-based study Leher Gumber, Reza Omidvar, Francesca Gonnelli, et al Lancet Rheumatol 2026; 8: e108-e115 https://doi.org/10.1016/S2665-9913(25)00292-9 Summary Background Previous research has suggested that the incidence of haemophagocytic lymphohistiocytosis is increasing in Europe. We aimed t...

Special Communication  Current Topics in Obesity World Health Organization Guideline on the Use and Indications of Glucagon-Like Peptide-1 Therapies for the Treatment of Obesity in Adults Francesca Celletti, Jeremy Farrar, Luz De Regil JAMA 2026;335;(5):434-438. doi:10.1001/jama.2025.24288 Abstract Importance  Obesity is a chronic, relapsing disease affecting over 1 billion people worldwide, driving substantial morbidity, mortality, and ec...

Articles Global burden of lower respiratory infections and aetiologies, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023 GBD 2023 Lower Respiratory Infections and Antimicrobial Resistance Collaborators Lancet Infect Dis Available online 15 December 2025 https://doi.org/10.1016/S1473-3099(25)00689-9 Summary Background Lower respiratory infections (LRIs) remain the world's leading infectious cause of death. This analysis from...

ESICM 2025 Guideline on Fluid Therapy in Adult Critically Ill Patients In Sepsis Wed, 29 Oct 2025 The European Society of Intensive Care Medicine (ESICM) convened an international panel of experts to develop evidence-based guidelines on fluid resuscitation volumes for adult critically ill patients with circulatory failure. This guideline represents Part 2 of a three-part series on fluid management, focusing specifically on resuscitation fluid volumes, ...

Comment Continued hope for late neuroprotection with minocycline Michael D Hill Lancet Available online 30 January 2026 https://doi.org/10.1016/S0140-6736(26)00047-4 Neuroprotection in ischaemic stroke commonly means a treatment that results in the preservation of brain tissue in the setting of either focal or global ischaemia. The nominal focus on neuronal tissue—the neuro in neuroprotection—might be misplaced, as the ultimate goal is preservation of the e...

Articles Cefiderocol versus standard therapy for hospital-acquired and health-care-associated Gram-negative bacterial bloodstream infection (the GAME CHANGER trial): an open-label, parallel-group, randomised trial David L Paterson, Helmi Sulaiman, Po-Yu Liu, et al Lancet Infect Dis 2026; 26: 148-159 https://doi.org/10.1016/S1473-3099(25)00469-4 Summary Background Bloodstream infections caused by bacteria with carbapenem resistance are associated with ...