Treatment Outcomes Among Patients With a Positive Candida Culture Close to Randomization Receiving Rezafungin or Caspofungin in the ReSTORE Study  Alex Soriano,  Patrick M Honore,  Oliver A Cornely,  et al Clinical Infectious Diseases, Volume 79, Issue 3, 15 September 2024, Pages 672–681, https://doi.org/10.1093/cid/ciae363 Abstract Background Rezafungin, a novel, once-weekly echinocandin for the treatment o...

Research The efficacy and safety of thymosin α1 for sepsis (TESTS): multicentre, double blinded, randomised, placebo controlled, phase 3 trial Jianfeng Wu, Fei Pei, Lixin Zhou, et al BMJ 2025; 388 doi: https://doi.org/10.1136/bmj-2024-082583 (Published 15 January 2025)Cite this as: BMJ 2025;388:e082583 Abstract Objective To evaluate whether the immunomodulatory drug thymosin α1 reduces mortality in adults with sepsis. Design Multicentre, double...

Antimicrobial Dosing in Critically Ill Patients on ECMO In ICU Mon, 14 Oct 2024 Extracorporeal membrane oxygenation (ECMO) is used to support critically ill patients, but its impact on antimicrobial pharmacokinetics (PK) and pharmacodynamics (PD) presents significant challenges. ECMO circuits can affect drug delivery, leading to the sequestration of drugs, changes in the volume of distribution (Vd), decreased clearance, and longer elimination half-life...

Original Investigation  Pacific Coast Surgical Association September 4, 2024 Mentorship of Junior Surgical Faculty Across Academic Programs in Surgery Jingjing Yu, Perisa Ruhi-Williams, Christian de Virgilio, et al JAMA Surg. 2024;159(11):1252-1260. doi:10.1001/jamasurg.2024.3390 Key Points Question  What is the current mentorship experience for junior surgical faculty and what are the challenges to re...

Original Investigation  August 21, 2024 High Fresh Frozen Plasma to Red Blood Cell Ratio and Survival Outcomes in Blunt Trauma Gaku Fujiwara, Yohei Okada, Wataru Ishii, et al JAMA Surg. 2024;159(11):1272-1280. doi:10.1001/jamasurg.2024.3097 Key Points Question  What is the association of a high fresh frozen plasma (FFP) to red blood cell (RBC) ratio with survival outcomes in patients with severe blunt tra...

Distinct Clinical Endpoints of Staphylococcus aureus Bacteraemia Complicate Assessment of Outcome  Clark D Russell,  Karla Berry,  George Cooper,  et al Clinical Infectious Diseases, Volume 79, Issue 3, 15 September 2024, Pages 604–611, https://doi.org/10.1093/cid/ciae281 Abstract Background We aimed to test the hypothesis that development of metastatic infection represents a distinct clinical endpoint from death due to&nb...

Original Investigation  August 28, 2024 Outcomes of Patients With Traumatic Brain Injury Transferred to Trauma Centers Sai Krishna Bhogadi, Collin Stewart, Hamidreza Hosseinpour, et al JAMA Surg. 2024;159(11):1282-1288. doi:10.1001/jamasurg.2024.3254 Key Points Question  What happens to patients with traumatic brain injury (TBI) who are transferred to higher-level trauma centers? Findings  In...

Leg Cycle Ergometry in Critically Ill Patients In ICU Mon, 14 Oct 2024 Physical rehabilitation interventions initiated in the ICU represent a proactive approach to reducing post-ICU impairments. While many clinical guidelines recommend starting rehabilitation during ICU care, there is no consensus on the optimal timing or specific type of intervention. The types of rehabilitation studied are diverse, leading to varying results across studies. Some rand...

Preventing New Gram-negative Resistance Through Beta-lactam De-escalation in Hospitalized Patients With Sepsis: A Retrospective Cohort Study  Besu F Teshome,  Taehwan Park,  Joel Arackal,  et al Clinical Infectious Diseases, Volume 79, Issue 4, 15 October 2024, Pages 826–833, https://doi.org/10.1093/cid/ciae253 Abstract Background Whether antibiotic de-escalation reduces the risk of subsequent antibiotic resistance is...

Editorial  November 11, 2024 Intratracheal Budesonide Combined With Surfactant in Extremely Preterm Infants Erik A. Jensen JAMA. Published online November 11, 2024. doi:10.1001/jama.2024.19641 Infants born extremely premature (those with gestational ages of less than 28 weeks at delivery) are at risk of both acute and subsequent chronic respiratory insufficiency due in part to absent or inadequate production of pulmonary surfactant. More than...