Original Investigation  Association of Rectal Cancer Accreditation with Patient Volume and Procedural Trends in the US Anthony Loria, Yusheng Jia, Ronald J. Weigel, et al JAMA Surg Published Online: May 6, 2026 doi: 10.1001/jamasurg.2026.1259 Key Points Question  Is National Accreditation Program for Rectal Cancer (NAPRC) accreditation associated with changes in rectal cancer patient volume, pro...

Comment Real-time subphenotyping in acute respiratory distress syndrome: a step towards precision medicine Denise Battaglini, Marcus J Schultz, Patricia R M Rocco The Lancet Respiratory Medicine, Available online 23 March 2026 https://doi.org/10.1016/S2213-2600(26)00054-8 Acute respiratory distress syndrome (ARDS) has long been defined by pragmatic clinical criteria that favour sensitivity over biological specificity. This strategy has enabled early recognitio...

Research Letter  Physician Work Environment and Well-Being Turnover and Burnout Among Family Physicians Dhruv Khullar, Lawrence P. Casalino, Richard G. Kronick, et al JAMA Intern Med 2026;186;(5):635-637. doi:10.1001/jamainternmed.2026.0271 Physician burnout may be associated with leaving practice or moving to a new practice, resulting in clinician shortages, especially in primary care.1 Evidence suggests that pa...

Original Investigation  Red Blood Cell Exchange Transfusion for Severe Babesiosis STOP-BABESIOSIS Investigators JAMA Intern Med 2026;186;(5):597-607. doi:10.1001/jamainternmed.2026.0244 Key Points Question  Is red blood cell exchange transfusion (ET) associated with improved clinical outcomes in patients hospitalized with severe babesiosis? Findings  In this multicenter cohort study of 629 patients hospitalized with severe b...

Original Investigation  Changes in Nonprofit Hospitals’ Finances, Operations, and Quality of Care After Using Management Consultants Joseph Dov Bruch, Cal Chengqi Fang, Yan Bo Zeng, et al JAMA Published Online: May 4, 2026 doi: 10.1001/jama.2026.5027 Key Points Question  How much do nonprofit hospitals spend on management consultants, and following the initiation of a management consulting contr...

ONLINE FIRST (FREE ACCESS) THE BRAIN IN THE LINE OF FIRE OPEN ACCESS ~ Narrative Review Temperature control in acute brain injuryLavinio, A., Busl, K.M., Coles, J.P. et al. OBESITY IN THE ICU What's New in Intensive Care Gaps or paradoxes in clinical responses in obese patientsHernández, G., Muñiz Albaiceta, G. & Thille, A.W. LATEST ARTICLES Original Low versus standard calorie and protein feeding and renal dysfunction in ventilated adults w...

Reducing Diagnostic Errors in Critical Illness  In ICU Fri, 31 Oct 2025 Accurate diagnosis underpins safe and effective critical care, yet the diagnostic process in acute illness is inherently vulnerable. Time pressure, evolving physiology and limited patient history often converge when illness is most severe. Critical illness is also encountered beyond intensive care units (ICUs) and in some cases follows earlier diagnostic missteps that escalate...

Original Investigation  Health Informatics Large Language Model Performance and Clinical Reasoning Tasks Arya S. Rao, Kaiz P. Esmail, Richard S. Lee, et al JAMA Netw Open 2026;9;(4):e264003. doi:10.1001/jamanetworkopen.2026.4003 Key Points Question  Can off-the-shelf large language models (LLMs) demonstrate reliable performance across the clinical workflow? Findings  In this cross-sectional s...

Original Investigation  Pediatrics Changes in Academic Standardized Testing After Pediatric Intensive Care Claire C. Foster, Melanie Boyd, Erin F. Carlton, et al JAMA Netw Open 2026;9;(4):e269948. doi:10.1001/jamanetworkopen.2026.9948 Key Points Question  Is pediatric intensive care unit (PICU) admission associated with a decrease in academic achievement assessment scores? Findings  In this c...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES Original Prophylactic noninvasive ventilation after extubation in high-risk patients without hypercapniaThille, A.W., Chamblet, L., Ragot, S. et al. OPEN ACCESS ~ Imaging in Intensive Care Medicine Demonstration of the acute hemodynamic effects of dynamic left ventricular outflow obstructionYao, R.J.R., Jiang, M., Lee, R. et al. OPEN ACCESS ~ Narrative Review Mechanical ventilation for ICU patient w...