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[NEJM发表述评]:不确定的答案:ICU中质子泵抑制剂的使用已关闭评论
EDITORIAL Uncertain Answers — Proton-Pump Inhibition in the ICU Samuel M. Brown N Engl J Med Published June 14, 2024 DOI: 10.1056/NEJMe2405782 A critical care clinician’s job includes administering timely and tailored antibiotics, expediting appropriate surgery, supporting a patient’s beleaguered body and mind until they are ready to recover, and preventing complications in this vulnerable state. This is surprisingly strenuous work, even if it is often, app...
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[JAMA发表述评]:钠-葡萄糖共转运蛋白2治疗重症患者急性器官功能障碍已关闭评论
Editorial  June 14, 2024 Sodium-Glucose Cotransporter 2 Therapy for Acute Organ Dysfunction in Critically Ill Patients Hernando Gómez, Lennie P. G. Derde JAMA. Published online June 14, 2024. doi:10.1001/jama.2024.10171 Multisystem organ dysfunction can follow several acute injury mechanisms, including trauma, sepsis, and shock and is the leading cause of death in critically ill patients.1 Even after the initial cause of organ injury has...
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[Lancet Infect Dis发表论文]:2019年85种致病微生物伴随的全球疾病负担已关闭评论
ARTICLES|ONLINE FIRST Global burden associated with 85 pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019 IHME Pathogen Core Group Lancet Infect Dis Published: April 16, 2024 DOI: https://doi.org/10.1016/S1473-3099(24)00158-0 Summary Background Despite a global epidemiological transition towards increased burden of non-communicable diseases, communicable diseases continue to cause substantial morbidity and mortality w...
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[JAMA Netw Open发表论文]:助产士或产科医生接生后产妇急诊科就诊情况已关闭评论
Original Investigation  Obstetrics and Gynecology April 29, 2024 Postpartum Emergency Department Use Following Midwifery-Model vs Obstetrics-Model Care Carla Sorbara, Joel G. Ray, MD, Elizabeth K. Darling, et al JAMA Netw Open. 2024;7(4):e248676. doi:10.1001/jamanetworkopen.2024.8676 Key Points Question  Is care by a midwife compared with an obstetrician associated with different rates of eme...
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[NEJM发表论文]:有创机械通气期间应激性溃疡的预防已关闭评论
ORIGINAL ARTICLE Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation Deborah Cook, Adam Deane, François Lauzier, et al N Engl J Med Published June 14, 2024 DOI: 10.1056/NEJMoa2404245 Abstract BACKGROUND Whether proton-pump inhibitors are beneficial or harmful for stress ulcer prophylaxis in critically ill patients undergoing invasive ventilation is unclear. METHODS In this international, randomized trial, we assigned critically ill a...
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[JAMA发表论文]:达格列净治疗重症患者的急性器官功能障碍已关闭评论
Original Investigation  Caring for the Critically Ill Patient June 14, 2024 Dapagliflozin for Critically Ill Patients With Acute Organ Dysfunction: The DEFENDER Randomized Clinical Trial Caio A. M. Tavares, Luciano C. P. Azevedo, Álvaro Rea-Neto, et al JAMA. Published online June 14, 2024. doi:10.1001/jama.2024.10510 Key Points Question  Does the addition of dapagliflozin to standard of care improve the hierarchical outcome of...
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[ICU Management & Practice]: 揭示HIF-1α在脓毒症中的作用已关闭评论
Unravelling the Role of HIF-1α in Sepsis In Sepsis Tue, 2 Apr 2024 A recent review explores the crucial role of hypoxia-inducible factor-1α (HIF-1α) in the development and progression of sepsis.  Hypoxia-inducible factor (HIF) is a protein complex consisting of a constitutively expressed subunit β and an oxygen-dependent subunit α. HIF-1α is associated with acute hypoxia and regulates glycolytic genes, oxygen consumption, and reactive oxygen sp...
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[NEJM发表论文]:颅脑创伤患者的自由或限制性输血策略已关闭评论
ORIGINAL ARTICLE Liberal or Restrictive Transfusion Strategy in Patients with Traumatic Brain Injury Alexis F. Turgeon, Dean A. Fergusson, Lucy Clayton, et al N Engl J Med Published June 13, 2024 DOI: 10.1056/NEJMoa2404360 Abstract BACKGROUND The effect of a liberal transfusion strategy as compared with a restrictive strategy on outcomes in critically ill patients with traumatic brain injury is unclear. METHODS We randomly assigned adults with m...
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[JAMA Netw Open发表论文]:心血管领域主要临床试验中事件发生率与效应值估计的准确性已关闭评论
Original Investigation  Cardiology April 30, 2024 Accuracy of Event Rate and Effect Size Estimation in Major Cardiovascular Trials: A Systematic Review Christoph B. Olivier, Lasse Struß, Nathalie Sünnen, et al JAMA Netw Open. 2024;7(4):e248818. doi:10.1001/jamanetworkopen.2024.8818 Key Points Question  How accurate are estimated event rates and effect sizes in contemporary cardiovascular rand...
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[NEJM发表论文]:急诊插管期间采用无创通气进行预氧合已关闭评论
ORIGINAL ARTICLE Noninvasive Ventilation for Preoxygenation during Emergency Intubation Kevin W. Gibbs, Matthew W. Semler, Brian E. Driver, et al N Engl J Med Published June 13, 2024 DOI: 10.1056/NEJMoa2313680 Abstract BACKGROUND Among critically ill adults undergoing tracheal intubation, hypoxemia increases the risk of cardiac arrest and death. The effect of preoxygenation with noninvasive ventilation, as compared with preoxygenation with an oxygen m...
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