Original Investigation  Public Health Air Purifier Intervention for Respiratory Viral Exposure in Elementary Schools: A Secondary Analysis of a Randomized Clinical Trial Ye Sun, Dastan Haghnazari, Ching-Ying Huang, et al JAMA Netw Open 2025;8;(10):e2536951. doi:10.1001/jamanetworkopen.2025.36951 Key Points Question  Is the use of high-efficiency particulate air (HEPA) purifiers associated with reduced res...

Research Special Paper Patterns of war related trauma in Gaza during armed conflict: survey study of international healthcare workers Omar El-Taji, Ameer Ali, Osaid Alser, et al BMJ 2025; 390 doi: https://doi.org/10.1136/bmj-2025-087524 (Published 25 September 2025)Cite this as: BMJ 2025;390:e087524 Abstract Objective To systematically document the patterns of war related injuries in Gaza, Palestine. Design Survey study of international he...

Factors Leading to CT Misinterpretation in the ED  In ICU Sat, 12 Jul 2025 Computed tomography (CT) has become a cornerstone of emergency department (ED) diagnostics due to its high sensitivity and rapid acquisition of detailed internal images. Emergency physicians (EPs) often initiate CT scans to guide urgent decisions, particularly in trauma and acute medical conditions. However, in settings where real-time radiologist interpretation is unavaila...

Research Non-invasive high frequency oscillatory ventilation for primary respiratory support in extremely preterm infants: multicentre randomised controlled trial Yang Li, Xingwang Zhu, Ling-Jun Li, et al BMJ 2025; 391 doi: https://doi.org/10.1136/bmj-2025-085569 (Published 06 October 2025)Cite this as: BMJ 2025;391:e085569 Abstract Objective To test the hypothesis that non-invasive high frequency oscillatory ventilation (NHFOV) is more efficacious tha...

Invited Commentary  Dexmedetomidine Infusion for Rib Fractures—Still in Search of the Right Indication? Joshua B. Brown JAMA Surg 2025;160;(10):1057. doi:10.1001/jamasurg.2025.3235 Dexmedetomidine is an α-2 agonist that garnered significant attention in recent years. Often used for sedation in the intensive care unit (ICU), it has advantages of lighter sedation with less respiratory depression compared with other agents.1 When studied in critically ill pa...

Original Investigation  Aging and Health Slow-Tempo Music and Delirium/Coma-Free Days Among Older Adults Undergoing Mechanical Ventilation: A Randomized Clinical Trial Babar A. Khan, Sikandar H. Khan, Anthony J. Perkins, et al JAMA Intern Med Published Online: October 13, 2025 doi: 10.1001/jamainternmed.2025.5263 Key Points Question  Among critically ill, mechanically ventilated older adults ...

Reducing Hospitalisations Through Risk Prediction  In ICU Mon, 7 Jul 2025 Preventing unplanned hospital admissions among older adults is an ongoing challenge for hospitals seeking to maintain patient safety while optimising resource use. Emergency admissions are associated with adverse outcomes, including cognitive decline, hospital-acquired infections and repeat admissions. Understanding the factors that contribute to such admissions is critical ...

Original Investigation  Proactive vs Reactive Treatment of Hypotension During Surgery: The PRETREAT Randomized Clinical Trial Matthijs Kant, Wilton A. van Klei, Markus W. Hollmann, et al JAMA Published Online: October 12, 2025 doi: 10.1001/jama.2025.18007 Key Points Question  Does intraoperative blood pressure management with a mean arterial pressure goal stratified by preoperatively determined ...

Original Investigation  Individualized Perioperative Blood Pressure Management in Patients Undergoing Major Abdominal Surgery: The IMPROVE-multi Randomized Clinical Trial Bernd Saugel, Agnes S. Meidert, Frank M. Brunkhorst, et al JAMA Published Online: October 12, 2025 doi: 10.1001/jama.2025.17235 Key Points Question  Does individualized perioperative blood pressure management based on preoperative n...

Mortality and Antibiotic Timing in Deep Learning-Derived Sepsis Risk Groups In Sepsis Tue, 15 Jul 2025 Sepsis affects over 1.7 million people annually in the U.S., causing more than 350,000 deaths and over $62 billion in healthcare costs. The 2021 Surviving Sepsis Campaign (SSC) guidelines recommend antibiotic timing based on illness severity and sepsis probability, creating four risk categories, but this classification is subjective and ofte...