Articles Invasive aspergillosis in liver transplant recipients in France (2007–21): a nationwide, retrospective, matched case–control study Coralie Le Hyaric, Cléa Melenotte, François Lefebvre, et al Lancet Microbe 2026; 7: 101272 https://doi.org/10.1016/j.lanmic.2025.101272  Summary Background Invasive aspergillosis is a rare but severe complication of liver transplantation. Incidence varies from 1·2% to 5·6% and mortality is greater than 50%. Few st...

Editorial  New Lungs for Lung Cancer—Perils and Promises Ece Cali Daylan, Ramaswamy Govindan JAMA Published Online: July 8, 2026 doi: 10.1001/jama.2026.11478 Despite the recent advances in systemic therapy, survival for patients with metastatic non–small cell lung cancer (NSCLC) without actionable genomic alterations in the tumor is limited.1 A small subset of patients with NSCLC have lung-only metastatic disease and often die of progressive lung failu...

ORIGINAL ARTICLE Oral Nirmatrelvir–Ritonavir for Covid-19 in Higher-Risk Outpatients Christopher C. Butler, Andrew D. Pinto, Victoria Harris, et al N Engl J Med 2026;394:1583-1594 DOI: 10.1056/NEJMoa2502457 Abstract BACKGROUND Nirmatrelvir–ritonavir has been shown to reduce progression to severe illness from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in unvaccinated high-risk outpatients. The effectiveness of nirmatrelvir–ritonavir i...

Original Investigation  Lung Transplant for Refractory Lung-Limited Stage IV Non–Small Cell Lung Cancer Ankit Bharat, Chitaru Kurihara, Liam IL-Young Chung, et al JAMA Published Online: July 8, 2026 doi: 10.1001/jama.2026.8717 Key Points Question  Among selected adults with medically refractory, lung-limited, stage IV non–small cell lung cancer (NSCLC), what are the outcomes with lung transplant and how does early overall survival compare ...

Editorial  A Multinational Trial of Rapid Antimicrobial Susceptibility Testing: Is FASTer Better? Arjun Srinivasan JAMA Published Online: April 18, 2026 doi: 10.1001/jama.2026.5504 Selecting the right antibiotic to treat an infection is the cornerstone of effective antibacterial therapy and lifesaving in severe infections.1 The growing epidemic of antimicrobial resistance is making decisions about empiric treatment increasingly difficult and elevating ...

Deep Learning Models for ICU Readmission Prediction In ICU Tue, 21 Oct 2025 The decision to discharge patients from the ICU is complex, as premature discharge increases the risk of readmission and mortality, while delayed discharge raises healthcare costs. ICU readmission is associated with over twice the mortality risk, longer hospital stays, greater morbidity, and higher resource use. Several predictive models, such as SWIFT, APACHE II and III, and S...

Original Investigation  Infectious Diseases Pharmacokinetics of Dalbavancin in Complicated Staphylococcus aureus Bacteremia: A Secondary Analysis of the DOTS Randomized Clinical Trial Thomas P. Lodise, Nicholas A. Turner, Toshimitsu Hamasaki, et al JAMA Netw Open 2026;9;(4):e2611652. doi:10.1001/jamanetworkopen.2026.11652 Key Points Question  What are the pharmacokinetics of a 2-dose dalbavancin regimen used for consolidation therapy in co...

Original Investigation  Dalbavancin for Treatment of Staphylococcus aureus Bacteremia: The DOTS Randomized Clinical Trial Nicholas A. Turner, Toshimitsu Hamasaki, Sarah B. Doernberg, et al JAMA 2025;334;(10):866-877. doi:10.1001/jama.2025.12543 Key Points Question  Is dalbavancin a superior treatment option for complicated Staphylococcus aureus bacteremia compared with standard care? F...

Invited Commentary  Health Informatics Limitations of Large Language Models in Clinical Diagnostic Reasoning Mickael Tordjman, Xueyan Mei JAMA Netw Open 2026;9;(4):e264014. doi:10.1001/jamanetworkopen.2026.4014 Large language models (LLMs) have rapidly gained an important role in multiple fields, including medicine. These widely available tools can enhance patient understanding, improve physician productivity, and provide encyclopedic knowledge on seve...

Pulmonary Haemodynamic Trajectories in ECMO-Supported ARDS In ICU Wed, 4 Mar 2026 A recent study investigated the prevalence, determinants, and prognostic implications of pulmonary hypertension (PH) in patients with acute respiratory distress syndrome (ARDS) supported with veno-venous extracorporeal membrane oxygenation (V-V ECMO). PH, defined as a mean pulmonary artery pressure (mPAP) greater than 20 mmHg, is a recognised complication of ARDS and cont...