Articles Global burden of lower respiratory infections and aetiologies, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023 GBD 2023 Lower Respiratory Infections and Antimicrobial Resistance Collaborators Lancet Infect Dis Available online 15 December 2025 https://doi.org/10.1016/S1473-3099(25)00689-9 Summary Background Lower respiratory infections (LRIs) remain the world's leading infectious cause of death. This analysis from...

ESICM 2025 Guideline on Fluid Therapy in Adult Critically Ill Patients In Sepsis Wed, 29 Oct 2025 The European Society of Intensive Care Medicine (ESICM) convened an international panel of experts to develop evidence-based guidelines on fluid resuscitation volumes for adult critically ill patients with circulatory failure. This guideline represents Part 2 of a three-part series on fluid management, focusing specifically on resuscitation fluid volumes, ...

Comment Continued hope for late neuroprotection with minocycline Michael D Hill Lancet Available online 30 January 2026 https://doi.org/10.1016/S0140-6736(26)00047-4 Neuroprotection in ischaemic stroke commonly means a treatment that results in the preservation of brain tissue in the setting of either focal or global ischaemia. The nominal focus on neuronal tissue—the neuro in neuroprotection—might be misplaced, as the ultimate goal is preservation of the e...

Articles Cefiderocol versus standard therapy for hospital-acquired and health-care-associated Gram-negative bacterial bloodstream infection (the GAME CHANGER trial): an open-label, parallel-group, randomised trial David L Paterson, Helmi Sulaiman, Po-Yu Liu, et al Lancet Infect Dis 2026; 26: 148-159 https://doi.org/10.1016/S1473-3099(25)00469-4 Summary Background Bloodstream infections caused by bacteria with carbapenem resistance are associated with ...

Review British Society for Medical Mycology best practice recommendations for the diagnosis of serious fungal diseases: 2025 update Silke Schelenz, Alireza Abdolrasouli, Darius Armstrong-James, et al Lancet Infect Dis Available online 10 November 2025 https://doi.org/10.1016/S1473-3099(25)00550-X Summary The fungal diagnostic landscape is evolving; whereas previously, traditional culture-based methods dominated, most invasive fungal disease is now diagno...

#LIVES2025: The Silent ICU  In ICU Tue, 28 Oct 2025 While therapeutic music addresses one aspect of the ICU soundscape, alarm management tackles another critical dimension. Margot Van Mol, Assistant Professor in Rotterdam, presented research on creating a smart and silent ICU that addresses the overwhelming alarm burden facing healthcare professionals and patients.  The statistics are sobering: ICU patients can be exposed to 100 to 1,000 a...

Articles Efficacy and safety of minocycline in patients with acute ischaemic stroke (EMPHASIS): a multicentre, double-blind, randomised controlled trial Yao Lu, Ling Guan, Jialing Wu, et al Lancet Available online 30 January 2026 https://doi.org/10.1016/S0140-6736(25)01862-8 Summary Background Minocycline has been reported as a multi-target anti-neuroinflammatory drug with potential benefits for ischaemic stroke in preclinical models and small-scale c...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES Original Sex, time, and disability status differences in mortality, multidimensional morbidity, and health care utilization: a secondary analysis of the Canadian RECOVER studyBurns, K.E.A., Huszti, E., Li, Q. et al. EditorialUpdate on infection: from prevention to diagnosis and managementNseir, S., Salluh, J.I.F. & Póvoa, P. Update on sepsis and septic shock: from bundles to precision medicinePlata-Menchaca, E....

#LIVES2025: The Role of Music in the ICU  In ICU Tue, 28 Oct 2025 The intensive care unit environment presents a paradox: while advanced monitoring technology is essential for patient care, the resulting noise pollution may harm the very patients it aims to protect. Two complementary approaches are emerging to address this challenge: therapeutic music interventions and innovative alarm management strategies that promise to...

Special Communication  Diagnosis and Treatment of Acute Appendicitis: 2025 Edition of the World Society of Emergency Surgery Jerusalem Guidelines Mauro Podda, Marco Ceresoli, Belinda De Simone, et al JAMA Surg Published Online: January 28, 2026 doi: 10.1001/jamasurg.2025.6218 Abstract Importance  Acute appendicitis is the most common abdominal surgical emergency worldwide and a leading cause of ...