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[MEDSCAPE]: 2017年3月临床医学趋势
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Clinical Trends for March 2017

Ryan Syrek

|March 31, 2017

Clinical Trend of the Week (March 18-24): Pneumonia

This week's top search term has an "inappropriate" cause. Two studies recently determined that inappropriate use of broad-spectrum antibiotics to treat pneumonia in children remains common. In one study, the electronic medical records of more than 10,000 children treated for pneumonia found that macrolides and other broad-spectrum antibiotics were prescribed more often than amoxicillin, the appropriate treatment as recommended by current guidelines. A second study reviewed treatment of children hospitalized for pneumonia at 28 different hospitals. Findings revealed that hospitals who created initiatives to boost adherence to guidelines saw a nearly 30% increase in appropriate prescriptions, compared with about 20% in hospitals without those initiatives. Together, these studies shed light on the state of antibiotic use in pediatric pneumonia and resulted in this week's top search term.

Clinical Trend of the Week (March 11-17): Plaque Psoriasis

A new drug's promising phase 3 trial findings resulted in this week's top search term. With no breakthrough tropical treatment for psoriasis since the 1980s, news that benvitimod, a nonsteroidal anti-inflammatory topical treatment, was safe and effective dramatically increased searches for the condition. The randomized, multicenter, placebo- and comparator-controlled trial of patients with mild to moderate plaque psoriasis found that rates of clearance or near-clearance among those receiving benvitimod were nearly twice that of the placebo group. This search is likely to remain popular as this potentially significant treatment advances towards approval.

Clinical Trend of the Week (March 4-10): ADHD

A "largest-ever" brain imaging study resulted in a large gain in popularity for this week's top search term. The findings of that study, published in The Lancet , revealed small but significant differences in the brain structures of those with attention deficit hyperactivity disorder (ADHD) compared with individuals without the condition. The study analyzed the MRI scans of more than 3,200 people (age 4 y to 63 y), roughly half of whom had a diagnosis of ADHD. The findings revealed that 5 of the 7 brain regions examined were smaller in people with ADHD, and those differences were more pronounced in children. Although early, the hope is that this research may suggest innovative diagnostic and treatment options.

Clinical Trend of the Week (February 25 – March 3): Influenza A

"Elevated" activity led to an elevation in the popularity of this week's top search term. The US Centers for Disease Control and Prevention (CDC) recently noted that influenza activity in the United States increased beginning in mid-December and remained elevated into February. Influenza A viruses comprised the majority of circulating viruses, with vaccine effectiveness against that group estimated to be 43%. Combined with the vaccine's 73% effectiveness against influenza B viruses, the results show that vaccination reduced the risk for outpatient medical visits by nearly half. As clinicians across the country continue to battle seasonal influenza, this term will no doubt remain of much interest.

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