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Research Letter June 15, 2020 Hospital-Wide SARS-CoV-2 Antibody Screening in 3056 Staff in a Tertiary Center in Belgium Deborah Steensels, Els Oris, Laura Coninx, et al JAMA. Published online June 15, 2020. doi:10.1001/jama.2020.11160 Belgium has a high burden of coronavirus disease 2019 (COVID-19), especially the region surrounding the Hospital East-Limburg, a tertiary care center.1 Infection prevention measures were instituted in the hospital ...
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ARTICLES|ONLINE FIRST GM-CSF blockade with mavrilimumab in severe COVID-19 pneumonia and systemic hyperinflammation: a single-centre, prospective cohort study Giacomo De Luca, Giulio Cavalli, Corrado Campochiaro, et al Lancet Rheumatol Published:June 16, 2020 DOI:https://doi.org/10.1016/S2665-9913(20)30170-3 Summary Background Mortality in patients with COVID-19 pneumonia and systemic hyperinflammation is high. We aimed to examine whether mavrilimumab, a...
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Research Letter | April 22, 2020 Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection Giacomo Spinato, Cristoforo Fabbris,  Jerry Polesel, et al JAMA. 2020;323(20):2089-2090. doi:10.1001/jama.2020.6771 Since December 2019, a pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally.1 A spectrum of disease severity has been reported, with m...
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Effect of Dexamethasone in Hospitalized Patients with COVID-19 – Preliminary Report RECOVERY Collaborative Group ABSTRACT Background: Coronavirus disease 2019 (COVID-19) is associated with diffuse lung damage. Corticosteroids may modulate immune-mediated lung injury and reducing progression to respiratory failure and death. Methods: The Randomised Evaluation of COVID-19 therapy (RECOVERY) trial is a randomized, controlled, open-label, adaptive, platform ...
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Original Investigation June 3, 2020 Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19: A Randomized Clinical Trial Ling Li, Wei Zhang, Yu Hu, et al JAMA. Published online June 3, 2020. doi:10.1001/jama.2020.10044 Abstract Importance Convalescent plasma is a potential therapeutic option for patients with coronavirus disease 2019 (COVID-19), but further data from rando...
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Original Investigation Caring for the Critically Ill Patient Association of Noninvasive Oxygenation Strategies With All-Cause Mortality in Adults With Acute Hypoxemic Respiratory Failure: A Systematic Review and Meta-analysis Bruno L. Ferreyro, Federico Angriman, Laveena Munshi, et al JAMA. Published online June 4, 2020. doi:10.1001/jama.2020.9524 Abstract Importance Treatment with noninvasive oxygenation strategies such as noninvasive ventilation and hi...
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ARTICLES| VOLUME 395, ISSUE 10241, P1927-1936, JUNE 20, 2020 Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial The HALT-IT Trial Collaborators Lancet Published: June 20, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)30848-5 Summary Background Tranexamic acid reduces surgical bleeding and...
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Where Are the Most Effective Anti-COVID-19 Strategies? The majority of countries have introduced at least some nation-wide measures aimed at containing the spread of the novel coronavirus pandemic. The measures include stopping/limiting international and domestic movement, closing educational facilities, banning public gatherings or announcing quarantine, to name a few. You may also like: COVID-19: Quarantine Measures, Laws and Limits As ISGlobal&n...
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Oxford University News Release EMBARGOED UNTIL 16 June 2020, 13:00 (UK Time)  Low-cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID-19 In March 2020, the RECOVERY (Randomised Evaluation of COVid-19 thERapY) trial was established as a randomised clinical trial to test a range of potential treatments for COVID-19, including low-dose dexamethasone (a steroid treatment). Over 11,500 patients h...
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News Covid-19: Experts question guidance to reuse PPE Abi Rimmer BMJ 2020; 369: m1577 doi: https://doi.org/10.1136/bmj.m1577 (Published 20 April 2020) Doctors have expressed concern over new guidance from Public Health England that recommends reusing personal protective equipment in the face of shortages.1 The guidance, which also recommends alternatives for unavailable equipment, has been seen as an admission by the government of the PPE shortages facing h...
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