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ORIGINAL ARTICLE
A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19
ACTIV-3/TICO LY-CoV555 Study Group
Abstract
BACKGROUND
LY-CoV555, a neutralizing monoclonal antibody, has been associated with a decrease in viral load and the frequency of hospitalizations or emergency department visits among outpatients with coronavirus disease 2019 (Covid-19). Data are needed on the effect of this antibody in patients who are hospitalized with Cov...
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Research Christmas 2020: House of God
The time to act is now: pseudo-systematic review
Nathan Ford, Grania Brigden, Tom Ellman, et al
BMJ 2020; 371:m4143 (Published 10 December 2020) doi: https://doi.org/10.1136/bmj.m4143
Abstract
Objective
To identify any medical or public health rationale for claims that the time to act is now.
Design
Pseudo-systematic review.
Data sources
PubMed.
Study selection
Studies that included the claim ...
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Original Investigation Caring for the Critically Ill Patient
Effect of a Lower vs Higher Positive End-Expiratory Pressure Strategy on Ventilator-Free Days in ICU Patients Without ARDS: A Randomized Clinical Trial
Writing Committee and Steering Committee for the RELAx Collaborative Group
JAMA. Published online December 9, 2020. doi:10.1001/jama.2020.23517
Abstract
Importance
It is uncertain whether invasive ventilation can use lower positive end-expirator...
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ONLINE FIRST THIS WEEK(FREE ACCESS)
Original ~ Chiumello D. et al. - Physiological and quantitative CT-scan characterization of COVID-19 and typical ARDS: a matched cohort studyNarrative Review ~ De Jong A. et al. - How to ventilate obese patients in the ICUUnderstanding the Disease ~ Jung B. et al. - Ten tips to optimize weaning and extubation success in the critically illNarrative Review ~ Goligher E.C. - Clinical strategies for implementing lung and diaphragm-...
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ARTICLES| VOLUME 20, ISSUE 10, P1161-1171, OCTOBER 01, 2020
Changes in colistin resistance and mcr-1 abundance in Escherichia coli of animal and human origins following the ban of colistin-positive additives in China: an epidemiological comparative study
Yang Wang, Chunyan Xu, Rong Zhang, et al
Lancet Infect Dis 2020; 20: 1161-1171
Summary 摘要
Background 背景
Following the discovery and emergence of the plasmid-mediated colistin resistance gene, mcr-1, ...
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ORIGINAL ARTICLE
Efficacy of Tocilizumab in Patients Hospitalized with Covid-19
John H. Stone, Matthew J. Frigault, Naomi J. Serling-Boyd, et al
N Engl J Med 2020; 383:2333-2344DOI: 10.1056/NEJMoa2028836
Abstract
BACKGROUND
The efficacy of interleukin-6 receptor blockade in hospitalized patients with coronavirus disease 2019 (Covid-19) who are not receiving mechanical ventilation is unclear.
METHODS
We performed a randomized, double-blind, placebo-...
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Preliminary Communication November 12, 2020
Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial
Eric J. Lenze, Caline Mattar, Charles F. Zorumski, et al
JAMA. Published online November 12, 2020. doi:10.1001/jama.2020.22760
Abstract
Importance
Coronavirus disease 2019 (COVID-19) may lead to serious illness as a result of an excessive immune response. Fluvoxamine may prevent...
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Original Investigation November 17, 2020
Effect of an Emergency Department Care Bundle on 30-Day Hospital Discharge and Survival Among Elderly Patients With Acute Heart Failure: The ELISABETH Randomized Clinical Trial
Yonathan Freund, Marine Cachanado, Quentin Delannoy, et al
JAMA. 2020;324(19):1948-1956. doi:10.1001/jama.2020.19378
Abstract
Importance
Clinical guidelines for the early management of acute heart failure in the emergency dep...
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ORIGINAL ARTICLE
Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results
WHO Solidarity Trial Consortium
N Engl J Med December 2, 2020DOI: 10.1056/NEJMoa2023184
Abstract
BACKGROUND
World Health Organization expert groups recommended mortality trials of four repurposed antiviral drugs — remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a — in patients hospitalized with coronavirus disease 2019 (Covid-19).
METHODS
...
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Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes
Daniel E Leisman, Lukas Ronner, Rachel Pinotti, et al
Lancet Respir Med Published:October 16, 2020 DOI:https://doi.org/10.1016/S2213-2600(20)30404-5
Summary
The description of a so-called cytokine storm in patients with COVID-19 has prompted consideration of anti-cytokine therapies, particularly interleukin-6 antagonist...
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