ORIGINAL ARTICLE A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19 ACTIV-3/TICO LY-CoV555 Study Group Abstract BACKGROUND LY-CoV555, a neutralizing monoclonal antibody, has been associated with a decrease in viral load and the frequency of hospitalizations or emergency department visits among outpatients with coronavirus disease 2019 (Covid-19). Data are needed on the effect of this antibody in patients who are hospitalized with Cov...

Research Christmas 2020: House of God The time to act is now: pseudo-systematic review Nathan Ford, Grania Brigden, Tom Ellman, et al BMJ 2020; 371:m4143 (Published 10 December 2020) doi: https://doi.org/10.1136/bmj.m4143  Abstract Objective To identify any medical or public health rationale for claims that the time to act is now. Design Pseudo-systematic review. Data sources PubMed. Study selection Studies that included the claim ...

Original Investigation Caring for the Critically Ill Patient Effect of a Lower vs Higher Positive End-Expiratory Pressure Strategy on Ventilator-Free Days in ICU Patients Without ARDS: A Randomized Clinical Trial Writing Committee and Steering Committee for the RELAx Collaborative Group JAMA. Published online December 9, 2020. doi:10.1001/jama.2020.23517 Abstract Importance It is uncertain whether invasive ventilation can use lower positive end-expirator...

ONLINE FIRST THIS WEEK(FREE ACCESS)  Original ~ Chiumello D. et al. - Physiological and quantitative CT-scan characterization of COVID-19 and typical ARDS: a matched cohort studyNarrative Review ~ De Jong A. et al. - How to ventilate obese patients in the ICUUnderstanding the Disease ~ Jung B. et al. - Ten tips to optimize weaning and extubation success in the critically illNarrative Review ~ Goligher E.C. - Clinical strategies for implementing lung and diaphragm-...

ARTICLES| VOLUME 20, ISSUE 10, P1161-1171, OCTOBER 01, 2020 Changes in colistin resistance and mcr-1 abundance in Escherichia coli of animal and human origins following the ban of colistin-positive additives in China: an epidemiological comparative study Yang Wang, Chunyan Xu, Rong Zhang, et al Lancet Infect Dis 2020; 20: 1161-1171 Summary 摘要 Background 背景 Following the discovery and emergence of the plasmid-mediated colistin resistance gene, mcr-1, ...

ORIGINAL ARTICLE Efficacy of Tocilizumab in Patients Hospitalized with Covid-19 John H. Stone, Matthew J. Frigault, Naomi J. Serling-Boyd, et al N Engl J Med 2020; 383:2333-2344DOI: 10.1056/NEJMoa2028836 Abstract BACKGROUND The efficacy of interleukin-6 receptor blockade in hospitalized patients with coronavirus disease 2019 (Covid-19) who are not receiving mechanical ventilation is unclear. METHODS We performed a randomized, double-blind, placebo-...

Preliminary Communication November 12, 2020 Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial Eric J. Lenze, Caline Mattar, Charles F. Zorumski, et al JAMA. Published online November 12, 2020. doi:10.1001/jama.2020.22760 Abstract Importance Coronavirus disease 2019 (COVID-19) may lead to serious illness as a result of an excessive immune response. Fluvoxamine may prevent...

Original Investigation November 17, 2020 Effect of an Emergency Department Care Bundle on 30-Day Hospital Discharge and Survival Among Elderly Patients With Acute Heart Failure: The ELISABETH Randomized Clinical Trial Yonathan Freund, Marine Cachanado, Quentin Delannoy, et al JAMA. 2020;324(19):1948-1956. doi:10.1001/jama.2020.19378 Abstract Importance Clinical guidelines for the early management of acute heart failure in the emergency dep...

ORIGINAL ARTICLE Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results WHO Solidarity Trial Consortium N Engl J Med December 2, 2020DOI: 10.1056/NEJMoa2023184 Abstract BACKGROUND World Health Organization expert groups recommended mortality trials of four repurposed antiviral drugs — remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a — in patients hospitalized with coronavirus disease 2019 (Covid-19). METHODS ...

Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes Daniel E Leisman, Lukas Ronner, Rachel Pinotti, et al Lancet Respir Med Published:October 16, 2020 DOI:https://doi.org/10.1016/S2213-2600(20)30404-5 Summary The description of a so-called cytokine storm in patients with COVID-19 has prompted consideration of anti-cytokine therapies, particularly interleukin-6 antagonist...