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Sevoflurane for Sedation in Acute Respiratory Distress Syndrome. A Randomized Controlled Pilot Study Matthieu Jabaudon, Pierre Boucher, Etienne Imhoff, et al. Am J Respir Crit Care Med 2017; 195: 792-800 Rationale: 背景 Sevoflurane improves gas exchange, and reduces alveolar edema and inflammation in preclinical studies of lung injury, but its therapeutic effects have never been investigated in acute respiratory distress syndrome (ARDS). 有关肺损伤的临床前研究显示,七...
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Epidemiology of Weaning Outcome according to a New Definition. The WIND Study Gaëtan Béduneau, Tài Pham, Frédérique Schortgen, et al. Am J Respir Crit Care Med 2017; 195: 772-783 Rationale: 背景 The weaning process concerns all patients receiving mechanical ventilation. A previous classification into simple, prolonged, and difficult weaning ignored weaning failure and presupposed the use of spontaneous breathing trials. 脱机过程涉及所有接受机械通气的患者。既往分类方法将患...
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Recovery after Acute Kidney Injury John A. Kellum, Florentina E. Sileanu, Azra Bihorac, et al Am J Respir Crit Care Med 2017; 195: 784-791 Rationale: 背景 Little is known about how acute kidney injury (AKI) resolves, and whether patterns of reversal of renal dysfunction differ among patients with respect to ultimate recovery. 有关急性肾损伤(AKI)的恢复过程,以及不同患者肾脏功能障碍的逆转模式知之甚少。 Objectives: 目的 We sought to examine different patterns for AKI revers...
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FDA Approvals > Medscape Medical News FDA Expands Use of Procalcitonin Test to Help Guide ABX Use Megan Brooks February 24, 2017 The US Food and Drug Administration (FDA) has cleared the expanded use of the Vidas Brahms procalcitonin (PCT) test to help clinicians determine whether antibiotic treatment should be initiated or stopped in patients with lower respiratory tract infections and stopped in patients with sepsis. The Vidas Brahms PCT assay, manufactured by bioMér...
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High-flow warm humidified oxygen versus standard low-flow nasal cannula oxygen for moderate bronchiolitis (HFWHO RCT): an open, phase 4, randomised controlled trial Elizabeth Kepreotes, Bruce Whitehead, John Attia, et al Lancet 2017; 389: 930-939 Summary Background 背景 Bronchiolitis is the most common lung infection in infants and treatment focuses on management of respiratory distress and hypoxia. High-flow warm humidified oxygen (HFWHO) is increasingly used, but has...
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Reuters Health Information Early High Protein Intake May Decrease Mortality in ICU Patients With Low Muscle Mass By Rob Goodier March 01, 2017 NEW YORK (Reuters Health) – Delivering high protein nutrition shortly after admission to intensive care may reduce the mortality risk for patients with low muscle mass, a retrospective study suggests. 一项回顾性研究提示,收入ICU后尽快给予高蛋白质营养可能降低肌肉减少患者的死亡风险。 “We found protein intake over days 2 to 4 to be si...
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Medscape > Clinical Trends Clinical Trends for February 2017 Ryan Syrek February 24, 2017 Each week, we identify one top search term, speculate as to what caused its popularity, and provide an infographic on a related condition. If you have thoughts about what’s trending and why, feel free to share them with us on Twitter or Facebook! Clinical Trend of the Week (February 18 - 24): Magnesium Deficiency Speculation into the death of a beloved celebrity resulted in this we...
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Prophylactic hydration to protect renal function from intravascular iodinated contrast material in patients at high risk of contrast-induced nephropathy (AMACING): a prospective, randomised, phase 3, controlled, open-label, non-inferiority trial Estelle C Nijssen, Roger J Rennenberg, Patty J Nelemans, et al Lancet 2017 (Published 20 February 2017) DOI: http://dx.doi.org/10.1016/S0140-6736(17)30057-0   Background 背景 Intravenous saline is recommended in clinical pract...
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Research Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data Adrian R Martineau, David A Jolliffe, Richard L Hooper, et al. doi: https://doi.org/10.1136/bmj.i6583 (Published 15 February 2017) Cite this as: BMJ 2017;356:i6583 Abstract Objectives To assess the overall effect of vitamin D supplementation on risk of acute respiratory tract infection, and to identify factors modifying this e...
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Research Letter February 21, 2017 Website Characteristics and Physician Reviews on Commercial Physician-Rating Websites Tara Lagu, Katherine Metayer, Michael Moran; et al. JAMA. 2017;317(7):766-768. doi:10.1001/jama.2016.18553 Patients are increasingly seeking information about physicians online. Nearly 60% report that online reviews are important when choosing a physician. Because publicly reported quality data are not reported at the physician level, patients must consul...
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