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Volume Controlled Ventilation does not Prevent Injurious Inflation during Spontaneous Effort Takeshi Yoshida, Susumu Nakahashi, Maria Aparecida Miyuki Nakamura, et al Am J Respir Crit Care Med 2017 Published on 17-February-2017 as 10.1164/rccm.201610-1972OC Rationale: 背景 Spontaneous breathing during mechanical ventilation increases transpulmonary pressure and tidal volume, and worsens lung injury. Intuitively, controlling tidal volume and transpulmonary pressure might li...
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Preliminary Communication | Caring for the Critically Ill Patient March 21, 2017 Effect of Intensive vs Moderate Alveolar Recruitment Strategies Added to Lung-Protective Ventilation on Postoperative Pulmonary Complications: A Randomized Clinical Trial Alcino Costa Leme, Ludhmila Abrahao Hajjar, Marcia S. Volpe, et al JAMA. Published online March 21, 2017. doi:10.1001/jama.2017.2297 Abstract Importance 背景 Perioperative lung-protective ventilation has been recommende...
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Original Investigation | Caring for the Critically Ill Patient March 21, 2017 Association Between US Norepinephrine Shortage and Mortality Among Patients With Septic Shock Emily Vail, Hayley B. Gershengorn, May Hua, et al JAMA. Published online March 21, 2017. doi:10.1001/jama.2017.2841 Abstract Importance 背景 Drug shortages in the United States are common, but their effect on patient care and outcomes has rarely been reported. 在美国,药品短缺非常普遍,但其对于患者...
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Original Investigation | Caring for the Critically Ill Patient March 21, 2017 Effect of Dexmedetomidine on Mortality and Ventilator-Free Days in Patients Requiring Mechanical Ventilation With Sepsis: A Randomized Clinical Trial Yu Kawazoe, Kyohei Miyamoto, Takeshi Morimoto, et al. JAMA. Published online March 21, 2017. doi:10.1001/jama.2017.2088 Abstract Importance 背景 Dexmedetomidine provides sedation for patients undergoing ventilation; however, its effects on m...
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Medscape Critical Care > Critical Issues Evidence Lacking for Volume-Controlled Ventilation in Critical Care Aaron B. Holley, MD Disclosures | March 24, 2017 Volume Controlled Ventilation Does Not Prevent Injurious Inflation During Spontaneous Effort Yoshida T, Nakahashi S, Nakamura MA, et al Am J Respir Crit Care Med. 2017 Feb 17. [Epub ahead of print] Background 背景 The ARDSNet trial of limited tidal volume (TV) has dictated ventilator settings for almost two decade...
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Persistent and Chronic Critical Illness Revised and reviewed 11 December 2016 Persistent and Chronic Critical Illness OVERVIEW Advances in intensive care have led to a growing cohort of patients of patients, who would have otherwise succumbed to acute illness, survive in a state dependent on prolonged intensive care therapies including mechanical ventilation heavy burden of costs to the individual, family and society requires extreme use of resources cause of considerabl...
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The Top 10 Clinical Trends of Early 2017 Ryan Syrek, MA  |  March 21, 2017 Top 10 Clinical Trends of Early 2017 Every week, we identify the top search term and speculate as to what resulted in the increase in popularity. We then pair that with an infographic based on the related clinical condition. This year has already seen some surprising terms surge in popularity. Here are the top 10 clinical trends of early 2017. Trend 10: Breast Augmentation  In mid-January, a...
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ORIGINAL ARTICLE Levosimendan in Patients with Left Ventricular Dysfunction Undergoing Cardiac Surgery Rajendra H. Mehta, Jeffrey D. Leimberger, Sean van Diepen, et al. March 19, 2017 DOI: 10.1056/NEJMoa1616218 BACKGROUND 背景 Levosimendan is an inotropic agent that has been shown in small studies to prevent or treat the low cardiac output syndrome after cardiac surgery. 左西孟旦是一种强心药物,小样本研究显示其能够预防或治疗心脏外科术后低心排综合征。 METHODS 方法 In a m...
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ORIGINAL ARTICLE Levosimendan for Hemodynamic Support after Cardiac Surgery Giovanni Landoni, Vladimir V. Lomivorotov, Gabriele Alvaro, et al. BACKGROUND 背景 Acute left ventricular dysfunction is a major complication of cardiac surgery and is associated with increased mortality. Meta-analyses of small trials suggest that levosimendan may result in a higher rate of survival among patients undergoing cardiac surgery. 急性左心室功能不全是心脏术后的主要并发症,伴随病死率升高...
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ORIGINAL ARTICLE Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis The PRISM Investigators March 21, 2017 DOI: 10.1056/NEJMoa1701380 BACKGROUND 背景 After a single-center trial and observational studies suggesting that early, goal-directed therapy (EGDT) reduced mortality from septic shock, three multicenter trials (ProCESS, ARISE, and ProMISe) showed no benefit. This meta-analysis of individual patient data from the three recent trials was desi...
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