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Hypothermia and Localized Cold Injury Joseph U Becker, MD | January 3, 2018 | Contributor Information The term hypothermia generally refers to inappropriate body temperature, usually resulting from deficient thermoregulation. It is commonly defined as a core body temperature lower than 35°C.[1,2] Hypothermia may be either accidental,[3] as in inadvertent overexposure to low temperatures, or intentional, as in therapeutic hypothermia after cardiac arrest. It may be either ...
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Balanced Crystalloids versus Saline in the Intensive Care Unit: The SALT Randomized Trial Matthew W. Semler, Jonathan P. Wanderer, Jesse M. Ehrenfeld, et al Am J Respir Crit Care Med 2017 May 15;195(10):1362-1372 ABSTRACT RATIONALE: 背景 Saline is the intravenous fluid most commonly administered to critically ill adults, but may be associated with acute kidney injury and death. Whether use of balanced crystalloids rather than saline affects patient outcomes remains unknown...
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Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis Philipp Schuetz, Yannick Wirz, Ramon Sager, et al Lancet Infect Dis 2018; 18: 95-107 Published Online October 13, 2017 http://dx.doi.org/10.1016/S1473-3099(17)30592-3 Summary Background 背景 In February, 2017, the US Food and Drug Administration approved the blood infection marker procalcitonin for guiding antibiotic therapy in patients with acute...
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Adjunctive Glucocorticoid Therapy in Patients with Septic Shock B. Venkatesh, S. Finfer, J. Cohen, D. Rajbhandari, et al N Engl J Med January 19, 2018 DOI: 10.1056/NEJMoa1705835 BACKGROUND 背景 Whether hydrocortisone reduces mortality among patients with septic shock is unclear. 氢化可的松能否降低感染性休克病死率尚不清楚。 METHODS 方法 We randomly assigned patients with septic shock who were undergoing mechanical ventilation to receive hydrocortisone (at a dose of 200 mg p...
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Intensive Care Medicine Ten Best Recent Articles (FREE ACCESS)  Yongfang Zhou et al. Early application of airway pressure release ventilation may reduce the duration of mechanical ventilation in acute respiratory distress syndrome. It was important to apply the physiology theoretical knowledge of APRV and the findings of recent experiment researches to standardise the APRV settings. The early use of the updated APRV methodology in patients with ARDS, was associated with be...
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Hypothermia and Localized Cold Injury Joseph U Becker, MD | January 3, 2018 | Contributor Information The term hypothermia generally refers to inappropriate body temperature, usually resulting from deficient thermoregulation. It is commonly defined as a core body temperature lower than 35°C.[1,2] Hypothermia may be either accidental,[3] as in inadvertent overexposure to low temperatures, or intentional, as in therapeutic hypothermia after cardiac arrest. It may be either ...
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The Top 10 Clinical Trends of 2017 Ryan Syrek, MA | December 21, 2017 | Contributor Information Every week, we identify a top search term and consider what news, new study, or other factor caused an increase in popularity. We combine this information with an infographic about key information regarding a related condition to create the Clinical Trend of the Week. You may be surprised at what search terms were most popular this year! Here are the top 10 clinical trends for...
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Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial Sandra van Brunschot, Janneke van Grinsven, Hjalmar C van Santvoort, et al Lancet 2018; 391: 51-58 Background 背景 Infected necrotising pancreatitis is a potentially lethal disease and an indication for invasive intervention. The surgical step-up approach is the standard treatment. A promising alternative is the endoscopic step-up approach. We compared both app...
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Ceftazidime-avibactam versus meropenem in nosocomial pneumonia, including ventilator-associated pneumonia (REPROVE): a randomised, double-blind, phase 3 non-inferiority trial Antoni Torres, Nanshan Zhong, Jan Pachl, et al Lancet Infect Dis 2017 Published Online December 15, 2017 http://dx.doi.org/10.1016/S1473-3099(17)30747-8 Summary Background 背景 Nosocomial pneumonia is commonly associated with antimicrobial-resistant Gram-negative pathogens. We aimed to assess the effi...
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Prolonged versus short-term intravenous infusion of antipseudomonal β-lactams for patients with sepsis: a systematic review and meta-analysis of randomised trials Konstantinos Z Vardakas, Georgios L Voulgaris, Athanasios Maliaros, et al Lancet Infect Dis 2018; 18: 108-20 Published Online October 25, 2017 http://dx.doi.org/10.1016/S1473-3099(17)30615-1 Summary Background 背景 The findings of randomised controlled trials (RCT), observational studies, and meta-analyses vary r...
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