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ORIGINAL ARTICLE Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine Steven D. Weisbord, Martin Gallagher, Hani Jneid, et al. N Engl J Med 2017; November 12, 2017DOI: 10.1056/NEJMoa1710933 BACKGROUND 背景 Intravenous sodium bicarbonate and oral acetylcysteine are widely used to prevent acute kidney injury and associated adverse outcomes after angiography without definitive evidence of their efficacy. 静脉碳酸氢钠和口服乙酰半胱氨酸广泛用于预防血管造影后的...
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Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients Angèle Gayet-Ageron, David Prieto-Merino, Katharine Ker, et al Lancet Published Online November 7, 2017 http://dx.doi.org/10.1016/S0140-6736(17)32455-8 Summary Background 背景 Antifibrinolytics reduce death from bleeding in trauma and post-partum haemorrhage. We examined the effect of trea...
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ORIGINAL ARTICLE Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery C. David Mazer, Richard P. Whitlock, Dean A. Fergusson, et al N Engl J Med 2017 November 12, 2017DOI: 10.1056/NEJMoa1711818 BACKGROUND 背景 The effect of a restrictive versus liberal red-cell transfusion strategy on clinical outcomes in patients undergoing cardiac surgery remains unclear. 限制与自由输血策略对接受心脏外科手术患者临床预后的影响尚不清楚。   METHODS 方法 In this multicente...
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Hyperbaric Oxygen Therapy Is Associated With Lower Short- and Long-Term Mortality in Patients With Carbon Monoxide Poisoning Chien-Cheng Huang, Chung-Han Ho, Yi-Chen Chen Chest 2017; 152: 943-953 DOI: http://dx.doi.org/10.1016/j.chest.2017.03.049 Background 背景 To date, there has been no consensus about the effect of hyperbaric oxygen therapy (HBOT) on the mortality of patients with carbon monoxide poisoning (COP). This retrospective nationwide population-based cohort ...
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Burden of Adult Community-acquired, Health-care-Associated, Hospital-Acquired, and Ventilator-Associated Pneumonia: New York City, 2010 to 2014 Rachel E. Corrado, David Lee, David E. Lucero, et al Chest 2017; 152: 930-942 DOI: http://dx.doi.org/10.1016/j.chest.2017.04.162 Background 背景 Although pneumonia is a leading cause of death in New York City (NYC), limited data exist about the settings in which pneumonia is acquired across NYC. Cases of pneumonia acquired in co...
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Original Investigation November 7, 2017 Factors Associated With Increases in US Health Care Spending, 1996-2013 Joseph L. Dieleman, Ellen Squires, Anthony L. Bui, et al. JAMA. 2017;318(17):1668-1678 doi:10.1001/jama.2017.15927 Abstract Importance 背景 Health care spending in the United States increased substantially from 1995 to 2015 and comprised 17.8% of the economy in 2015. Understanding the relationship between known factors and spending increases over time could...
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Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2) Jean Reignier, Julie Boisramé-Helms, Laurent Brisard, et al Lancet Published: 08 November 2017 DOI: http://dx.doi.org/10.1016/S0140-6736(17)32146-3 Summary Background 背景 Whether the route of early feeding affects outcomes of patients with severe critical illnesses is controversial. We hypothesised that outcome...
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Aortic Dissection Lars Grimm, MD, MHS | October 30, 2017 | Contributor Information image from Medscape. An aortic dissection (arrows) is demonstrated above. The sudden onset of tearing chest pain may be the initial presentation of an acute aortic dissection. A small tear in the aortic intima can quickly split the aortic wall and create a swiftly expanding false lumen, which may be rapidly fatal even with prompt medical treatment. Image from Medscape. A false lumen (yello...
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Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial Sandra van Brunschot, Janneke van Grinsven, Hjalmar C van Santvoort, et al. Lancet 2017 epub ahead of print DOI: http://dx.doi.org/10.1016/S0140-6736(17)32404-2 Summary Background 背景 Infected necrotising pancreatitis is a potentially lethal disease and an indication for invasive intervention. The surgical step-up approach is the standard treatment. A promisin...
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Drugs & Diseases > Clinical Trends Clinical Trends for October 2017 Ryan Syrek October 27, 2017 Each week, we identify one top search term, speculate as to what caused its popularity, and provide an infographic on a related condition. If you have thoughts about what's trending and why, feel free to share them with us on Twitter or Facebook! Clinical Trend of the Week (October 21-27): Viral Encephalitis Several pieces of news from around the world combined to infl...
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