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Original Investigation May 8, 2018 Association of Vasopressin Plus Catecholamine Vasopressors vs Catecholamines Alone With Atrial Fibrillation in Patients With Distributive Shock: A Systematic Review and Meta-analysis William F. McIntyre, Kevin J. Um, Waleed Alhazzani, et al JAMA. 2018;319(18):1889-1900. doi:10.1001/jama.2018.4528 Abstract Importance Vasopressin is an alternative to catecholamine vasopressors for patients with distributive shock—a condition due to ex...
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News > Medscape Medical News > Conference News > ATS 2018 Discharge From a Crowded Hospital Ward Ups Readmission Risk Ingrid Hein May 21, 2018 Patients discharged from crowded hospital wards are more likely to be readmitted to the hospital in the subsequent 30 days, new data show. The three strongest predictors of a patient's readmission "are all modifiable, ward-level factors," said lead researcher Rachel Kohn, MD, from the University of Pennsylvania in Philad...
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Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial Nikola Sprigg, Katie Flaherty, Jason P Appleton, et al. Lancet  Published: 16 May 2018 DOI: https://doi.org/10.1016/S0140-6736(18)31033-X Summary Background Tranexamic acid can prevent death due to bleeding after trauma and post-partum haemorrhage. We aimed to assess whether tranexamic acid reduces haematoma expansion and ...
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What is the ICU Charts app? Patient care within an intensive care unit (ICU) is challenging and can lead well-intentioned critical care physicians to neglect some of the fundamental aspects of daily care. Care of the critically ill patient is often punctuated with physiologic changes that require immediate attention. Given the frequency of emergent and urgent interventions, ICU clinicians may be distracted from important, but less urgent, tasks that are still essential fo...
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Hydrocortisone plus Fludrocortisone for Adults with Septic Shock Annane D, Renault A, Brun-Buisson C, et al N Engl J Med. 2018 Mar 1; 378(9): 809-818. doi: 10.1056/NEJMoa1705716. Abstract BACKGROUND: 背景 Septic shock is characterized by dysregulation of the host response to infection, with circulatory, cellular, and metabolic abnormalities. We hypothesized that therapy with hydrocortisone plus fludrocortisone or with drotrecogin alfa (activated), which can modulate the h...
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ORIGINAL ARTICLE Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome Alain Combes, David Hajage, Gilles Capellier, et al N Engl J Med 2018; 378:1965-1975 DOI: 10.1056/NEJMoa1800385 Abstract BACKGROUND 背景 The efficacy of venovenous extracorporeal membrane oxygenation (ECMO) in patients with severe acute respiratory distress syndrome (ARDS) remains controversial. vvECMO对严重ARDS患者的疗效仍存在争议。 METHODS 方法 In an international clinical...
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Intensive Care Medicine ONLINE FIRST THIS WEEK (FREE ACCESS) The Surviving Sepsis Campaign (SSC) has released a new updated Hour-1 Bundle to reflect the latest evidence from the International Guidelines for Management of Sepsis and Septic Shock 2016. In this revision of the SSC bundles, the 3-hour and 6-hour bundles have been combined into a single “Hour-1 Bundle” with the explicit intention of beginning resuscitation and management immediately. This new sepsis “Hour-1 Bun...
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Intravenous Immune Globulin to Prevent Heparin-Induced Thrombocytopenia Theodore E. Warkentin, Troy H. Climans, Pierre-Aurèle Morin N Engl J Med 2018; 378:1845-1848 DOI: 10.1056/NEJMc1801799 TO THE EDITOR: Heparin-induced thrombocytopenia is a prothrombotic drug reaction caused by anti–platelet factor 4 (PF4)–heparin antibodies of the IgG class that activate platelets through platelet Fcγ receptors.1 Although treatment with nonheparin anticoagulation is emphasized, recent ...
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Early corticosteroids for Pneumocystis pneumonia in adults without HIV are not associated with better outcome Patrick M. Wieruszewski, Jason N. Barreto, Erin Frazee, et al Chest 2018 DOI: 10.1016/j.chest.2018.04.026 ABSTRACT Background: 背景 Evidence supporting adjunctive corticosteroids during the treatment of Pneumocystis pneumonia (PcP) in adults without human immunodeficiency virus (HIV) is minimal and controversial. 对于HIV阴性成年PcP患者而言,支持皮质激素辅助治疗的证...
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Intensive Care Medicine ONLINE FIRST THIS WEEK (FREE ACCESS) Letter ~ Thomas Marian et al. Are intensive care physicians aware of dysphagia? The MADICU survey results. Correspondence ~ Shunsuke Taito et al. Do change of care and rehabilitation for patients with mechanical ventilation increase chances of return to work? Editorial Debate ~ Laurent Papazian et al. Should all ICU clinicians regularly be tested for burnout? Yes. Editorial Debate ~ Bara Ricou et al. Should all I...
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