Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial  Samir Jaber, Catherine Paugam, Emmanuel Futier, et al Lancet 2018 Published: 14 June 2018 DOI: https://doi.org/10.1016/S0140-6736(18)31080-8 Summary Background 背景 Acute acidaemia is frequently observed during critical illness. Sodium bicarbonate infusion for the treatment of severe metabolic ac...

Intensive Care Medicine ONLINE FIRST THIS WEEK (FREE ACCESS) Letter ~ Marine Goudelin et al. Diagnostic capability of a next-generation, ultra-miniaturized ultrasound system in patients with cardiopulmonary compromise assessed using basic critical care echocardiography. What's New in Intensive Care ~ Fekri Abroug et al. Scorpion envenomation: from a neglected to a helpful disease? Original ~ Li Weng et al. Sepsis-related mortality in China: a descriptive analysis. Imaging ...

ORIGINAL ARTICLE A Randomized Trial of a Family-Support Intervention in Intensive Care Units Douglas B. White, Derek C. Angus, Anne-Marie Shields, et al N Engl J Med 2018; 378:2365-2375 DOI: 10.1056/NEJMoa1802637 Abstract BACKGROUND 背景 Surrogate decision makers for incapacitated, critically ill patients often struggle with decisions related to goals of care. Such decisions cause psychological distress in surrogates and may lead to treatment that does not align with patie...

ORIGINAL ARTICLE Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection David T. Huang, Donald M. Yealy, Michael R. Filbin, et al Abstract BACKGROUND 背景 The effect of procalcitonin-guided use of antibiotics on treatment for suspected lower respiratory tract infection is unclear. 降钙素原指导抗生素治疗疑似下呼吸道感染的作用尚不清楚。 METHODS 方法 In 14 U.S. hospitals with high adherence to quality measures for the treatment of pneumonia, we provided...

Intensive Care Medicine ONLINE FIRST THIS WEEK (FREE ACCESS) Editorial debate ~ ​Jean-François Timsit and Matteo Bassett. Antipathy against SDD is justified: Yes. Editorial debate ~ Luciano Silvestri et al. Antipathy against SDD is justified: No. ​ Editorial debate ~ Michael Quintel et al. Antipathy against SDD is justified: We are not sure. Original ~ Elie Azoulay et al. Management and outcomes of acute respiratory distress syndrome patients with and without comorbid cond...

CORRESPONDENCE ICU Admissions for Sepsis or Pneumonia in Australia and New Zealand in 2017 Aidan Burrell, Sue Huckson, David V. Pilcher for the ANZICS N Engl J Med 2018; 378:2138-2139 DOI: 10.1056/NEJMc1717178 TO THE EDITOR: Seasonal patterns of presentations to intensive care units (ICUs) in the Southern Hemisphere can inform health care planning for critically ill patients worldwide, as was seen during the H1N1 influenza pandemic in 2009.1 During the late winter and earl...

Original Investigation May 20, 2018 Association of the Quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA) Score With Excess Hospital Mortality in Adults With Suspected Infection in Low- and Middle-Income Countries Kristina E. Rudd, Christopher W. Seymour, Adam R. Aluisio, et al JAMA. Published online May 20, 2018. doi:10.1001/jama.2018.6229 Abstract Importance 背景 The quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA) score has not be...

Medical News & Perspectives May 22/29, 2018 Taking a Closer Look at the Biomarker Test for Mild Traumatic Brain Injury Rebecca Voelker, MSJ JAMA. 2018;319(20):2066-2067. doi:10.1001/jama.2018.4644 Not long after a first-of-its-kind blood test received approval to evaluate patients with mild traumatic brain injury, headlines dubbed it a “concussion test.” But experts in biomarkers are clarifying certain misconceptions about what the test can and can’t reveal. “It’s ...

Original Investigation June 5, 2018 Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration Lisa M. Askie, Brian A. Darlow, Neil Finer, et al. JAMA. 2018;319(21):2190-2201. doi:10.1001/jama.2018.5725 Abstract Importance 背景 There are potential benefits and harms of hyperoxemia and hypoxemia for extremely preterm infants receiving more vs less supplemental...

Intensive Care Medicine ONLINE FIRST THIS WEEK (FREE ACCESS) What's New in Intensive Care ~ R. T. Mankowski et al. Long-term impact of sepsis on cardiovascular health. Original ~ Mieke Deschepper et al. Effects of chlorhexidine gluconate oral care on hospital mortality: a hospital-wide, observational cohort study. Review ~ Antoine Vieillard-Baron et al. Diagnostic workup, etiologies and management of acute right ventricle failure. Review ~ Spyros D. Mentzelopoulos et al....