Original Investigation March 13, 2020 Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China Chaomin Wu, Xiaoyan Chen, Yanping Cai, et al JAMA Intern Med. 2020;180(7):934-943. doi:10.1001/jamainternmed.2020.0994 Abstract Importance 背景 Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that was first reported in Wuhan, China, and has subsequen...

Original Investigation August 18, 2020 Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial Ari Moskowitz, David T. Huang, Peter C. Hou, et al JAMA. 2020;324(7):642-650. doi:10.1001/jama.2020.11946 Abstract Importance 背景 The combination of ascorbic acid, corticosteroids, and thiamine has been identified as a potential therapy for septic shock. 联合应用维生素C、皮质...

Original Published: 11 August 2020 Combination therapy of vitamin C and thiamine for septic shock: a multi-centre, double-blinded randomized, controlled study Sung Yeon Hwang, Seung Mok Ryoo, Jong Eun Park, et al Intensive Care Med 2020 Purpose 目的 To evaluate the effects of early combination therapy with intravenous vitamin C and thiamine on recovery from organ failure in patients with septic shock. 评估静脉维生素C与维生素B1早期联合治疗...

ONLINE FIRST THIS WEEK(FREE ACCESS) Conference Reports and Expert Panel ~ Verweij P.E. et al. - Review of influenza-associated pulmonary aspergillosis in ICU patients and proposal for a case definition: an expert opinion Systematic Review ~ Fleischmann-Struzek C. et al. - Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis Narrative Review&nbs...

Special Communication August 3, 2020 Determination of Brain Death/Death by Neurologic Criteria: The World Brain Death Project David M. Greer, Sam D. Shemie, Ariane Lewis, et al JAMA. Published online August 3, 2020. doi:10.1001/jama.2020.11586 Abstract Importance 背景 There are inconsistencies in concept, criteria, practice, and documentation of brain death/death by neurologic criteria (BD/DNC) both internatio...

ARTICLES| VOLUME 396, ISSUE 10245, P177-185, JULY 18, 2020 Dexmedetomidine for reduction of atrial fibrillation and delirium after cardiac surgery (DECADE): a randomised placebo-controlled trial Alparslan Turan, Andra Duncan, Steve Leung, et al Lancet Published:July 18, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)30631-0 Summary Background Atrial fibrillation and delirium are common consequences of cardiac surgery. Dexmedetomidine has unique propertie...

ARTICLES| VOLUME 396, ISSUE 10245, P167-176, JULY 18, 2020 Urgent endoscopic retrograde cholangiopancreatography with sphincterotomy versus conservative treatment in predicted severe acute gallstone pancreatitis (APEC): a multicentre randomised controlled trial Nicolien J Schepers, Nora D L Hallensleben, Marc G Besselink, et al Lancet Published:July 18, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)30539-0 Summary Background It remains un...

ICU Management & Practice, Volume 20 - Issue 1, 2020 Intensive Care in the Coronavirus Era: Keep in Mind Your Collective Intelligence Above and beyond the logistical and organisational aspects, shaken by the COVID-19 pandemic, here is an overview of our experience as an intensive care team in Switzerland. We will not parade the efficient measures implemented in our institution in preparation for welcoming COVID-19 patients; rather, we will discuss the im...

ICU Management & Practice, Volume 20 - Issue 1, 2020 A COVID-19 Dashboard: Data Analytics to Aid Resource Allocation in Intensive Care Units In this article, we focus on clinical and practical application of current available cloud-based data analysis to track and benchmark in real-time suspect and confirmed COVID-19 cases, resource use and availability. Introduction The COVID-19 pandemic represents an unprecedented challenge to intensive care units (...

Original Investigation July 28, 2020 Effect of Intravenous Acetaminophen on Postoperative Hypoxemia After Abdominal Surgery: The FACTOR Randomized Clinical Trial Alparslan Turan, Hani Essber,Wael Saasouh, et al JAMA. 2020;324(4):350-358. doi:10.1001/jama.2020.10009 Abstract Importance 背景 Opioid-induced ventilatory depression and hypoxemia is common, severe, and often unrecognized in postoperative patients. To the extent that nonopioid an...