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Prevalence, risk factors, outcomes, and molecular epidemiology of mcr-1-positive Enterobacteriaceae in patients and healthy adults from China: an epidemiological and clinical study Yang Wang, Guo-Bao Tian, Rong Zhang, et al Lancet Infect Dis 2017; 17: 390-399 DOI: http://dx.doi.org/10.1016/S1473-3099(16)30527-8 Summary Background 背景 The mcr-1 gene confers transferable colistin resistance. mcr-1-positive Enterobacteriaceae (MCRPE) have attracted substantial medical, me...
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Prevalence of mcr-1 in Escherichia coli and Klebsiella pneumoniae recovered from bloodstream infections in China: a multicentre longitudinal study Jingjing Quan, Xi Li, Yan Chen, et al Lancent Infect Dis 2017; 17: 400-410 DOI: http://dx.doi.org/10.1016/S1473-3099(16)30528-X Summary Background 背景 Polymyxin antibiotics are used as last-resort therapies to treat infections caused by multidrug-resistant Gram-negative bacteria. The plasmid-mediated colistin resistance dete...
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Original Investigation April 2017 Comparative Effectiveness of Vancomycin and Metronidazole for the Prevention of Recurrence and Death in Patients With Clostridium difficile Infection Vanessa W. Stevens; Richard E. Nelson; Elyse M. Schwab-Daugherty, et al JAMA Intern Med. 2017;177(4):546-553. doi:10.1001/jamainternmed.2016.9045 Abstract Importance 背景 Metronidazole hydrochloride has historically been considered first-line therapy for patients with mild to moder...
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Prophylactic platelet transfusion plus supportive care versus supportive care alone in adults with dengue and thrombocytopenia: a multicentre, open-label, randomised, superiority trial David C Lye, Sophia Archuleta, Sharifah F Syed-Omar, et al. Lancet DOI: http://dx.doi.org/10.1016/S0140-6736(17)30269-6 Summary Background 背景 Dengue is the commonest vector-borne infection worldwide. It is often associated with thrombocytopenia, and prophylactic platelet transfusion is...
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Kidney Injury and Repair Biomarkers in Marathon Runners Sherry G. Mansour, Gagan Verma, Rachel W. Pata, et al. Am J Kidney Dis 2017 (Epub ahead of print) http://dx.doi.org/10.1053/j.ajkd.2017.01.045 Background: 背景 Investigation into strenuous activity and kidney function has gained interest given increasing marathon participation. 由于参加马拉松比赛的热情日增,有关剧烈运动与肾功能的研究也引发了人们的兴趣。 Study Design: 研究设计 Prospective observational study. 前瞻观察...
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Medscape > Clinical Trends Clinical Trends for March 2017 Ryan Syrek |March 31, 2017 Clinical Trend of the Week (March 18-24): Pneumonia This week's top search term has an "inappropriate" cause. Two studies recently determined that inappropriate use of broad-spectrum antibiotics to treat pneumonia in children remains common. In one study, the electronic medical records of more than 10,000 children treated for pneumonia found that macrolides and other broad-spectrum anti...
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Volume Controlled Ventilation does not Prevent Injurious Inflation during Spontaneous Effort Takeshi Yoshida, Susumu Nakahashi, Maria Aparecida Miyuki Nakamura, et al Am J Respir Crit Care Med 2017 Published on 17-February-2017 as 10.1164/rccm.201610-1972OC Rationale: 背景 Spontaneous breathing during mechanical ventilation increases transpulmonary pressure and tidal volume, and worsens lung injury. Intuitively, controlling tidal volume and transpulmonary pressure might li...
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Preliminary Communication | Caring for the Critically Ill Patient March 21, 2017 Effect of Intensive vs Moderate Alveolar Recruitment Strategies Added to Lung-Protective Ventilation on Postoperative Pulmonary Complications: A Randomized Clinical Trial Alcino Costa Leme, Ludhmila Abrahao Hajjar, Marcia S. Volpe, et al JAMA. Published online March 21, 2017. doi:10.1001/jama.2017.2297 Abstract Importance 背景 Perioperative lung-protective ventilation has been recommende...
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Original Investigation | Caring for the Critically Ill Patient March 21, 2017 Association Between US Norepinephrine Shortage and Mortality Among Patients With Septic Shock Emily Vail, Hayley B. Gershengorn, May Hua, et al JAMA. Published online March 21, 2017. doi:10.1001/jama.2017.2841 Abstract Importance 背景 Drug shortages in the United States are common, but their effect on patient care and outcomes has rarely been reported. 在美国,药品短缺非常普遍,但其对于患者...
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Original Investigation | Caring for the Critically Ill Patient March 21, 2017 Effect of Dexmedetomidine on Mortality and Ventilator-Free Days in Patients Requiring Mechanical Ventilation With Sepsis: A Randomized Clinical Trial Yu Kawazoe, Kyohei Miyamoto, Takeshi Morimoto, et al. JAMA. Published online March 21, 2017. doi:10.1001/jama.2017.2088 Abstract Importance 背景 Dexmedetomidine provides sedation for patients undergoing ventilation; however, its effects on m...
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