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Original Investigation December 26, 2017 Association of Short-term Exposure to Air Pollution With Mortality in Older Adults Qian Di, Lingzhen Dai, Yun Wang, et al. JAMA. 2017;318(24):2446-2456. doi:10.1001/jama.2017.17923 Abstract Importance 背景 The US Environmental Protection Agency is required to reexamine its National Ambient Air Quality Standards (NAAQS) every 5 years, but evidence of mortality risk is lacking at air pollution levels below the current daily NAAQ...
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Original Investigation December 26, 2017 Effect of Antibiotic Prophylaxis on Surgical Site Infections Following Removal of Orthopedic Implants Used for Treatment of Foot, Ankle, and Lower Leg Fractures: A Randomized Clinical Trial Manouk Backes, MD, Siem A. Dingemans, Marcel G. W. Dijkgraaf, et al JAMA. 2017;318(24):2438-2445. doi:10.1001/jama.2017.19343 Abstract Importance 背景 Following clean (class I, not contaminated) surgical procedures, the rate of surgical sit...
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Access the Top Ten Hottest Articles of 2017 Dear Readers, 2017 has been an incredible year for cutting-edge basic and translational research! As we bid adieu to this year and welcome 2018, to ensure you've not missed anything, we've listed some of the hottest OPEN ACCESS articles to appear in Intensive Care Medicine Experimental below: 1) Research ~ Konstantinos Vardas et al. Increased glucocorticoid receptor expression in sepsis is related to heat shock proteins, cytokine...
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News Sepsis Early Warning Score Adopted in UK Peter Russell December 20, 2017 Every NHS hospital trust in England will be asked to adopt a new clinical system for assessing acutely ill patients. 英格兰每所NHS医院都将被要求采用一种新的临床系统评估急性病患者。 Almost 2,000 deaths each year could be prevented if consistent checks are made, according to the NHS. 根据NHS报告,如果系统采用这一评分,每年能够避免将近2000名患者的死亡。 The National Early Warning Score (NEWS), d...
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Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study Rudy Sinharay, Jicheng Gong, Benjamin Barratt, et al Lancet 2017 Published online December 5, 2017 http://dx.doi.org/10.1016/ S0140-6736(17)32643-0 Summary Background Long-term exposure to pollution can lead t...
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Original Investigation December 19, 2017 Association of Broad- vs Narrow-Spectrum Antibiotics With Treatment Failure, Adverse Events, and Quality of Life in Children With Acute Respiratory Tract Infections Jeffrey S. Gerber, Rachael K. Ross, Matthew Bryan, et al JAMA. 2017;318(23):2325-2336. doi:10.1001/jama.2017.18715 Abstract Importance 背景 Acute respiratory tract infections account for the majority of antibiotic exposure in children, and broad-spectrum antibiotic...
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Intensive Care Medicine ONLINE FIRST THIS WEEK Original ~ Claude Guérin et al. A prospective international observational prevalence study on prone positioning of ARDS patients: the APRONET (ARDS Prone Position Network) study. Systematic Review ~ François Lamontagne et al. Pooled analysis of higher versus lower blood pressure targets for vasopressor therapy septic and vasodilatory shock. Original ~ Luregn J. Schlapbach et al. Prognostic accuracy of age-adapted SOFA, SIRS,...
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Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial Guy E Thwaites, Matthew Scarborough, Alexander Szubert, et al Lancet 2017 online first DOI: http://dx.doi.org/10.1016/S0140-6736(17)32456-X Summary Background 背景 Staphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampici...
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Estimates of global seasonal influenza-associated respiratory mortality: a modelling study A Danielle Iuliano, Katherine M Roguski, Howard H Chang, et al Lancet 2017 online first DOI: http://dx.doi.org/10.1016/S0140-6736(17)33293-2 Summary Background 背景 Estimates of influenza-associated mortality are important for national and international decision making on public health priorities. Previous estimates of 250 000–500 000 annual influenza deaths are outdated. We update...
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Original Investigation December 12, 2017 Diagnostic Assessment of Deep Learning Algorithms for Detection of Lymph Node Metastases in Women With Breast Cancer Babak Ehteshami Bejnordi, Mitko Veta, Paul Johannes van Diest, et al. JAMA. 2017;318(22):2199-2210. doi:10.1001/jama.2017.14585 Abstract Importance 背景 Application of deep learning algorithms to whole-slide pathology images can potentially improve diagnostic accuracy and efficiency. 对全片病理图像应用深度学习...
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