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Hypothermia and Localized Cold Injury Joseph U Becker, MD | January 3, 2018 | Contributor Information The term hypothermia generally refers to inappropriate body temperature, usually resulting from deficient thermoregulation. It is commonly defined as a core body temperature lower than 35°C.[1,2] Hypothermia may be either accidental,[3] as in inadvertent overexposure to low temperatures, or intentional, as in therapeutic hypothermia after cardiac arrest. It may be either ...
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The Top 10 Clinical Trends of 2017 Ryan Syrek, MA | December 21, 2017 | Contributor Information Every week, we identify a top search term and consider what news, new study, or other factor caused an increase in popularity. We combine this information with an infographic about key information regarding a related condition to create the Clinical Trend of the Week. You may be surprised at what search terms were most popular this year! Here are the top 10 clinical trends for...
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Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial Sandra van Brunschot, Janneke van Grinsven, Hjalmar C van Santvoort, et al Lancet 2018; 391: 51-58 Background 背景 Infected necrotising pancreatitis is a potentially lethal disease and an indication for invasive intervention. The surgical step-up approach is the standard treatment. A promising alternative is the endoscopic step-up approach. We compared both app...
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Ceftazidime-avibactam versus meropenem in nosocomial pneumonia, including ventilator-associated pneumonia (REPROVE): a randomised, double-blind, phase 3 non-inferiority trial Antoni Torres, Nanshan Zhong, Jan Pachl, et al Lancet Infect Dis 2017 Published Online December 15, 2017 http://dx.doi.org/10.1016/S1473-3099(17)30747-8 Summary Background 背景 Nosocomial pneumonia is commonly associated with antimicrobial-resistant Gram-negative pathogens. We aimed to assess the effi...
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Prolonged versus short-term intravenous infusion of antipseudomonal β-lactams for patients with sepsis: a systematic review and meta-analysis of randomised trials Konstantinos Z Vardakas, Georgios L Voulgaris, Athanasios Maliaros, et al Lancet Infect Dis 2018; 18: 108-20 Published Online October 25, 2017 http://dx.doi.org/10.1016/S1473-3099(17)30615-1 Summary Background 背景 The findings of randomised controlled trials (RCT), observational studies, and meta-analyses vary r...
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Original Investigation January 9, 2018 Association Between Handover of Anesthesia Care and Adverse Postoperative Outcomes Among Patients Undergoing Major Surgery Philip M. Jones, Richard A. Cherry, Britney N. Allen, et al JAMA. 2018;319(2):143-153. doi:10.1001/jama.2017.20040 Importance 背景 Handing over the care of a patient from one anesthesiologist to another occurs during some surgeries and might increase the risk of adverse outcomes. 部分手术期间可能出现患者的麻醉...
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Original Investigation December 26, 2017 Association of Hospitalist Years of Experience With Mortality in the Hospitalized Medicare Population James S. Goodwin, Habeeb Salameh, Jie Zhou, et al. JAMA Intern Med. Published online December 26, 2017. doi:10.1001/jamainternmed.2017.7049 Abstract Importance 背景 Substantial numbers of hospitalists are fresh graduates of residency training programs. Current data about the effect of hospitalist years of experience on pat...
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News > Medscape Medical News > FDA Approvals FDA Clears Angiotensin II (Giapreza) for Septic Shock Megan Brooks December 21, 2017 The US Food and Drug Administration (FDA) has approved angiotensin II injection for intravenous infusion (Giapreza, La Jolla Pharmaceutical Co) to increase blood pressure in adults with septic shock or other distributive shock, the agency announced December 21. "Shock, the inability to maintain blood flow to vital tissues, can result ...
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original article Safety of Magnetic Resonance Imaging in Patients with Cardiac Devices Saman Nazarian, Rozann Hansford, Amir A. Rahsepar, et al N Engl J Med 2017;377:2555-64. DOI: 10.1056/NEJMoa1604267 BACKGROUND 背景 Patients who have pacemakers or defibrillators are often denied the opportunity to undergo magnetic resonance imaging (MRI) because of safety concerns, unless the devices meet certain criteria specified by the Food and Drug Administration (termed “MRI-conditi...
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ICU Management & Practice most read in 2017 We’ve crunched the numbers and scanned the stats to bring you the highlights of 2017 - our most read and shared journal articles and news. Our sincere thanks go to to our contributors, our Editorial Board and Editor-in-Chief, Prof. Jean-Louis Vincent. You might also like: Most read in 2016 in ICU Management & Practice From the Journal Albumin administration in sepsis: the case for and against The current evidence base d...
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