Intensive Care Medicine ONLINE FIRST THIS WEEK (FREE ACCESS) Letter ~ Maxime Coutrot et al. Euglycemic ketoacidosis, a common and underecognised complication of continuous renal replacement therapy using glucose-free solutions. From the Inside ~ Daniel Brodie et al. There’s more to medicine than machines. What's New in Intensive Care ~ Matthieu Schmidt et al. Have we averted deaths using venoarterial ECMO? Understanding the Disease ~ Hans Flaatten et al. Understanding card...

Original Investigation Caring for the Critically Ill Patient February 27, 2018 Effect of On-Demand vs Routine Nebulization of Acetylcysteine With Salbutamol on Ventilator-Free Days in Intensive Care Unit Patients Receiving Invasive Ventilation: A Randomized Clinical Trial David M. P. van Meenen, Sophia M. van der Hoeven, Jan M. Binnekade, et al JAMA. Published online February 27, 2018. doi:10.1001/jama.2018.0949 Abstract Importance 背景 It remains uncertain whether n...

Articles Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals Nathalie Conrad, Andrew Judge, Jenny Tran, et al Lancet 2018; 391: 572-580 Summary Background 背景 Large-scale and contemporary population-based studies of heart failure incidence are needed to inform resource planning and research prioritisation but current evidence is scarce. We aimed to assess temporal trends in incidence and prevalence of heart failur...

Intensive Care Medicine ONLINE FIRST THIS WEEK (FREE ACCESS) Imaging in Intensive Care Medicine ~ Paul Gabarre et al. An acute dyspnea. Letter ~ Laëtitia Bodet-Contentin et al. Eye-tracking and speech-generating technology to improve communication with intubated intensive care unit patients: initial experience. Imaging in Intensive Care Medicine ~ Tobias Gonzenbach et al. Accidental placement of a dialysis catheter into the accessory hemiazygos vein. Letter ~ Néstor Pistil...

Influenza Strikes Again: 100 Years After Great Pandemic Steven Rourke | February 9, 2018 Image courtesy of the National Archives The Great Influenza of 1918-1919 Occurring in three distinct waves[1-4] at the tail end of World War I, the Great Influenza was the most lethal influenza pandemic in history, which, worldwide, is believed to have killed approximately 50 million people[1-3]—although estimates of numbers of victims range from 20 million to 100 million.[1,2,4] Influ...

Original Investigation February 13, 2018 Effect of the Pulmonary Embolism Rule-Out Criteria on Subsequent Thromboembolic Events Among Low-Risk Emergency Department PatientsThe PROPER Randomized Clinical Trial Yonathan Freund, MD, Marine Cachanado, Adeline Aubry, et al JAMA. 2018;319(6):559-566. doi:10.1001/jama.2017.21904 Abstract Importance 背景 The safety of the pulmonary embolism rule-out criteria (PERC), an 8-item block of clinical criteria aimed at ruling out pu...

ORIGINAL ARTICLE Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine Steven D. Weisbord, Martin Gallagher, Hani Jneid, et al N Engl J Med 2018; 378:603-614 DOI: 10.1056/NEJMoa1710933 Abstract BACKGROUND 背景 Intravenous sodium bicarbonate and oral acetylcysteine are widely used to prevent acute kidney injury and associated adverse outcomes after angiography without definitive evidence of their efficacy. 静脉碳酸氢钠及口服乙酰半胱氨酸广泛用于预防血管造影后...

Balanced Crystalloids versus Saline in Noncritically Ill Adults Wesley H. Self, Matthew W. Semler, Jonathan P. Wanderer, et al N Engl J Med February 27, 2018 DOI: 10.1056/NEJMoa1711586 Abstract BACKGROUND 背景 Comparative clinical effects of balanced crystalloids and saline are uncertain, particularly in noncritically ill patients cared for outside an intensive care unit (ICU). 平衡盐溶液与生理盐水临床疗效的比较结果尚不确切，尤其在ICU之外的非危重病患者。 METHODS 方法 We co...

Intensive Care Medicine ONLINE FIRST THIS WEEK (FREE ACCESS) From the Inside ~ Erwin J. O. Kompanje. Burnout, boreout and compassion fatigue on the ICU: it is not about work stress, but about lack of existential significance and professional performance. Conference Reports and Expert Panel  ~ Darryl Abrams et al. Position paper for the organisation of ECMO programs for cardiac failure in adults. Original ~ Jean-Louis Vincent et al. Comparison of European ICU patients in 20...

Balanced Crystalloids versus Saline in Critically Ill Adults Matthew W. Semler, Wesley H. Self, Jonathan P. Wanderer, et al N Engl J Med February 27, 2018 DOI: 10.1056/NEJMoa1711584 Abstract BACKGROUND 背景 Both balanced crystalloids and saline are used for intravenous fluid administration in critically ill adults, but it is not known which results in better clinical outcomes. 平衡盐溶液及生理盐水均可用于成年危重病患者的静脉输液治疗，但对临床结局的影响尚不清楚。 METHODS 方...