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Nebulised heparin for patients with or at risk of acute respiratory distress syndrome: a multicentre, randomised, double-blind, placebo-controlled phase 3 trial
Barry Dixon, Roger J Smith, Duncan J Campbell, et al
Lancet Respir Med Published:January 22, 2021 DOI:https://doi.org/10.1016/S2213-2600(20)30470-7
Summary
Background
Mechanical ventilation in intensive care for 48 h or longer is associated with the acute respiratory distress syndrome (ARDS), which ...
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Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries
GlobalSurg Collaborative and National Institute for Health Research Global Health Research Unit on Global Surgery
Lancet 2021; 397: 387–97
Summary
Background
80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LM...
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Original Contribution October 8, 2003
Safety of Patients Isolated for Infection Control
Henry Thomas Stelfox, David W. Bates, Donald A. Redelmeier, et al
JAMA 2003;290(14):1899-1905. doi:10.1001/jama.290.14.1899
Abstract
Context 背景
Hospital infection control policies that use patient isolation prevent nosocomial transmission of infectious diseases, but may inadvertently lead to patient neglect and errors.
医院的感染控制措施要求对患者进行隔离以...
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Oxygen Therapy in Acute Care Medicine
Oxygen therapy is a commonly used strategy in modern medicine. In most situations with declining oxygen saturations, clinicians are quick to use this technique. While effective in the setting of hypoxia, there are, however, some circumstances in which excess oxygen is indiscriminately administered for extended periods.
In healthcare, there has been a significant shift from the concept of "more is better" to "less is more." There...
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2021年01月24日
⁄ 时讯速递
CORRESPONDENCE
Racial Bias in Pulse Oximetry Measurement
Michael W. Sjoding, Robert P. Dickson, Theodore J. Iwashyna, et al
N Engl J Med 2020; 383:2477-2478DOI: 10.1056/NEJMc2029240
TO THE EDITOR:
Oxygen is among the most frequently administered medical therapies, with a level that is commonly adjusted according to the reading on a pulse oximeter that measures patients’ oxygen saturation. Questions about pulse oximeter technology have been raised, given its...
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ORIGINAL ARTICLE
Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia
Carlos Salama, Jian Han, Linda Yau, et al
N Engl J Med 2021; 384:20-30DOI: 10.1056/NEJMoa2030340
Abstract
BACKGROUND
Coronavirus disease 2019 (Covid-19) pneumonia is often associated with hyperinflammation. Despite the disproportionate incidence of Covid-19 among underserved and racial and ethnic minority populations, the safety and efficacy of the anti–interleukin-6 recep...
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Research Letter December 14, 2020
Readmission and Death After Initial Hospital Discharge Among Patients With COVID-19 in a Large Multihospital System
John P. Donnelly, Xiao Qing Wang, Theodore J. Iwashyna, et al
JAMA. Published online December 14, 2020. doi:10.1001/jama.2020.21465
Although more patients are surviving severe coronavirus disease 2019 (COVID-19), there are limited data on outcomes after initial hospitalization. We therefore measure...
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Research Christmas 2020: The Citadel
Nonsensus in the treatment of proximal humerus fractures: uncontrolled, blinded, comparative behavioural analysis between Homo chirurgicus accidentus and Macaca sylvanus
Sam Razaeian, Birgitt Wiese, Dafang Zhang, et al
BMJ 2020; 371: m4429 doi: https://doi.org/10.1136/bmj.m4429 (Published 14 December 2020)
Abstract
Objective
To investigate the inter-rater reliability of Barbary macaques compared with an expert g...
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From The Medical Letter on Drugs and Therapeutics
An EUA for Bamlanivimab—A Monoclonal Antibody for COVID-19
JAMA. Published online December 11, 2020. doi:10.1001/jama.2020.24415
The investigational neutralizing IgG1 monoclonal antibody bamlanivimab (LY-CoV555; Lilly) has been granted an FDA Emergency Use Authorization (EUA) for treatment of recently diagnosed mild to moderate COVID-19 in patients who are ≥12 years old, weigh at least 40 kg, and are at high ...
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Research Christmas 2020: Dr Strange
Effectiveness of hospital clowns for symptom management in paediatrics: systematic review of randomised and non-randomised controlled trials
Luís Carlos Lopes-Júnior, Emiliana Bomfim, Karin Olson, et al
BMJ 2020; 371: m4290 doi: https://doi.org/10.1136/bmj.m4290 (Published 16 December 2020)
Abstract
Objective
To evaluate evidence from randomised controlled trials and non-randomised controlled trials on the effecti...
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