News & Perspective Attack in Manchester: Emergency Services Response Isabelle Catala, MD May 26, 2017 MANCHESTER, UK — The suicide attack that took place as people were leaving the Ariana Grande concert at the Manchester Arena on May 22 injured more than 60 attendees and killed 22 people (12 of whom, between the ages of 8 and 50, have been identified as at May 24). Emergency services were quickly deployed in accordance with national recommendations put in place i...

Original Investigation Caring for the Critically Ill Patient Discriminative Accuracy of Physician and Nurse Predictions for Survival and Functional Outcomes 6 Months After an ICU Admission Michael E. Detsky, Michael O. Harhay, Dominique F. Bayard, et al JAMA. Published online May 21, 2017. doi:10.1001/jama.2017.4078 Abstract Importance 背景 Predictions of long-term survival and functional outcomes influence decision making for critically ill patients, yet little is k...

Drugs & Diseases > Clinical Trends Clinical Trends for May 2017 Ryan Syrek May 26, 2017 Each week, we identify one top search term, speculate as to what caused its popularity, and provide an infographic on a related condition. If you have thoughts about what's trending and why, feel free to share them with us on Twitter or Facebook! Clinical Trend of the Week (May 20-26): NSAIDs Some troubling news about a popular class of drugs resulted in this week's top search...

本周在线发表文章（免费阅读） ONLINE FIRST THIS WEEK (FREE ACCESS) Review ~ Alain Combes et al. The ICM research agenda on extracorporeal life support. Original ~ Jean-François Timsit et al. Appropriate endpoints for evaluation of new antibiotic therapies for severe infections: a perspective from COMBACTE’s STAT-Net. Original ~ Frank Bloos et al. Effect of a multifaceted educational intervention for anti-infectious measures on sepsis mortality: a cluster randomised trial....

Effect of laminar airflow ventilation on surgical site infections: a systematic review and meta-analysis Peter Bischoff, Peter Bischoff, N Zeynep Kubilay, et al Lancet Infect Dis 2017; 17: 553-561 DOI: http://dx.doi.org/10.1016/S1473-3099(17)30059-2 Summary Background 背景 The role of the operating room's ventilation system in the prevention of surgical site infections (SSIs) is widely discussed, and existing guidelines do not reflect current evidence. In this context, ...

ORIGINAL ARTICLE Time to Treatment and Mortality during Mandated Emergency Care for Sepsis Christopher W. Seymour, Foster Gesten, Hallie C. Prescott, et al. N Engl J Med May 21, 2017 DOI: 10.1056/NEJMoa1703058 BACKGROUND 背景 In 2013, New York began requiring hospitals to follow protocols for the early identification and treatment of sepsis. However, there is controversy about whether more rapid treatment of sepsis improves outcomes in patients. 2013年，纽约州开始要求所有...

ORIGINAL ARTICLE Angiotensin II for the Treatment of Vasodilatory Shock Ashish Khanna, Shane W. English, Xueyuan S. Wang, et al. N Engl J Med May 21, 2017 DOI: 10.1056/NEJMoa1704154 BACKGROUND 背景 Vasodilatory shock that does not respond to high-dose vasopressors is associated with high mortality. We investigated the effectiveness of angiotensin II for the treatment of patients with this condition. 对大剂量升压药物无反应的血管舒张性休克伴随很高的病死率。我们研究了这种情...

Research Short term use of oral corticosteroids and related harms among adults in the United States: population based cohort study Akbar K Waljee, Mary A M Rogers, Paul Lin, et al. BMJ 2017; 357 doi: https://doi.org/10.1136/bmj.j1415 (Published 12 April 2017) Cite this as: BMJ 2017;357:j1415 Abstract Objective 背景 To determine the frequency of prescriptions for short term use of oral corticosteroids, and adverse events (sepsis, venous thromboembolism, fractures) associate...

Abdominal Aortic Aneurysm: Has the Bubble Burst? Rick C Jiang, MBBS, BMedSc, PostGradDipSurgAnat, FRACS; Mark P Brady, PA-C | May 10, 2017 An aneurysm is defined as an increase of greater than 50% from the vessel's original size. For an abdominal aortic aneurysm (AAA), this equates to a diameter of approximately 3 cm. The larger the aneurysm, the greater the risk of rupture. AAAs are commonly diagnosed either incidentally or when they become symptomatic or rupture. Whereas...

ARTICLES OF THE MONTH ORIGINAL ~ The risk and clinical outcome of candidemia Lortholary O et al. The risk and clinical outcomes of candidemia depending on underlying malignancy. The clinical context of underlying malignancy and hospitalisation in ICU may be relevant to the initial management of candidemia. ARTICLE REVIEW ORIGINAL ~ Fluid administration in severe sepsis and septic shock Marik PE et al. Fluid Administration in Severe Sepsis and Septic shock, Patterns and Out...