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ORIGINAL ARTICLE Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU Mette Krag, Søren Marker, Anders Perner, et al N Engl J Med October 24, 2018 DOI: 10.1056/NEJMoa1714919 Abstract BACKGROUND 背景 Prophylaxis for gastrointestinal stress ulceration is frequently given to patients in the intensive care unit (ICU), but its risks and benefits are unclear. ICU患者常常接受胃肠道应激性溃疡的预防,但其风险及获益并不清楚。 METHODS 方法 In this European, multi...
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Original Investigation October 22, 2018 Decontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients: A Randomized Clinical Trial Bastiaan H. Wittekamp, Nienke L. Plantinga, Ben S. Cooper, et al JAMA. Published online October 22, 2018. doi:10.1001/jama.2018.13765 Abstract Importance 背景 The effects of chlorhexidine (CHX) mouthwash, selective oropharyngeal decontamination (SOD), and selective digestive tract de...
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Original Investigation October 22, 2018 Effect of Protocolized Weaning With Early Extubation to Noninvasive Ventilation vs Invasive Weaning on Time to Liberation From Mechanical Ventilation Among Patients With Respiratory Failure: The Breathe Randomized Clinical Trial Gavin D. Perkins, Dipesh Mistry, Simon Gates, et al JAMA. Published online October 22, 2018. doi:10.1001/jama.2018.13763 Abstract Importance 背景 In adults in whom weaning from invasive mechanical v...
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ORIGINAL ARTICLE Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis Saber D. Barbar, Raphaël Clere-Jehl, Abderrahmane Bourredjem, et al N Engl J Med 2018; 379:1431-1442 DOI: 10.1056/NEJMoa1803213 Abstract BACKGROUND 背景 Acute kidney injury is the most frequent complication in patients with septic shock and is an independent risk factor for death. Although renal-replacement therapy is the standard of care for severe acute kidney injury, the...
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Research Association between physician US News & World Report medical school ranking and patient outcomes and costs of care: observational study Yusuke Tsugawa, Daniel M Blumenthal, Ashish K Jha, et al. Cite this as: BMJ 2018;362:k3640 Abstract Objective 目的 To investigate whether the US News & World Report (USNWR) ranking of the medical school a physician attended is associated with patient outcomes and healthcare spending. 研究医生毕业的医学院美...
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Research Laparoscopic cholecystectomy versus percutaneous catheter drainage for acute cholecystitis in high risk patients (CHOCOLATE): multicentre randomised clinical trial Charlotte S Loozen, Hjalmar C van Santvoort, Peter van Duijvendijk, et al BMJ 2018; 363 doi: https://doi.org/10.1136/bmj.k3965 (Published 08 October 2018)Cite this as: BMJ 2018;363:k3965 Abstract Objective 目的 To assess whether laparoscopic cholecystectomy is superior to percutaneous catheter draina...
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Original Investigation October 16, 2018 Effect of Theophylline as Adjunct to Inhaled Corticosteroids on Exacerbations in Patients With COPD: A Randomized Clinical Trial Graham Devereux, Seonaidh Cotton, Shona Fielding, et al JAMA. 2018;320(15):1548-1559. doi:10.1001/jama.2018.14432 Abstract Importance 背景 Chronic obstructive pulmonary disease (COPD) is a major global health issue and theophylline is used extensively. Preclinical investigations have demonstrated ...
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ORIGINAL ARTICLE A Candida auris Outbreak and Its Control in an Intensive Care Setting David W. Eyre, Anna E. Sheppard, Hilary Madder, et al N Engl J Med 2018; 379:1322-1331 DOI: 10.1056/NEJMoa1714373 Abstract BACKGROUND 背景 Candida auris is an emerging and multidrug-resistant pathogen. Here we report the epidemiology of a hospital outbreak of C. auris colonization and infection. 耳念珠菌是一种新出现的多重耐药致病菌。我们报告了医院内爆发耳念珠菌定植与感染的流行病学。 METH...
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Original Investigation Caring for the Critically Ill Patient October 9, 2018 Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients With Septic Shock and Elevated Endotoxin Level: The EUPHRATES Randomized Clinical Trial R. Phillip Dellinger, Sean M. Bagshaw, Massimo Antonelli, et al. JAMA. 2018;320(14):1455-1463. doi:10.1001/jama.2018.14618 Abstract Importance 背景 Polymyxin B hemoperfusion reduces blood endotoxin levels in sepsis. Endotoxin...
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ORIGINAL ARTICLE Six-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery C. David Mazer, Richard P. Whitlock, Dean A. Fergusson, et al N Engl J Med 2018; 379:1224-1233 DOI: 10.1056/NEJMoa1808561 Abstract BACKGROUND 背景 We reported previously that, in patients undergoing cardiac surgery who were at moderate-to-high risk for death, a restrictive transfusion strategy was noninferior to a liberal strategy with respect to the composite outcome of death ...
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