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ORIGINAL ARTICLE
Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults
Romina Libster, Gonzalo Pérez Marc, Diego Wappner, et al
N Engl J Med January 6, 2021DOI: 10.1056/NEJMoa2033700
Abstract
BACKGROUND
Therapies to interrupt the progression of early coronavirus disease 2019 (Covid-19) remain elusive. Among them, convalescent plasma administered to hospitalized patients has been unsuccessful, perhaps because antibodies should be...
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ARTICLES| VOLUME 397, ISSUE 10273, P499-509, FEBRUARY 06, 2021
Posaconazole versus voriconazole for primary treatment of invasive aspergillosis: a phase 3, randomised, controlled, non-inferiority trial
Johan A Maertens, Galia Rahav, Dong-Gun Lee, et al
Lancet 2021; 397: 499-509
Summary
Background
Voriconazole has been recommended as primary treatment for patients with invasive aspergillosis. Intravenous and tablet formulations of posaconaz...
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ORIGINAL ARTICLE
Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis
Christopher G. Hughes, Patrick T. Mailloux, John W. Devlin
N Engl J Med February 2, 2021DOI: 10.1056/NEJMoa2024922
Abstract
BACKGROUND
Guidelines currently recommend targeting light sedation with dexmedetomidine or propofol for adults receiving mechanical ventilation. Differences exist between these sedatives in arousability, immunity, and inflammation...
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Research
Electronic health record alerts for acute kidney injury: multicenter, randomized clinical trial
F Perry Wilson, Melissa Martin, Yu Yamamoto, et al
BMJ 2021; 372: m4786 doi: https://doi.org/10.1136/bmj.m4786 (Published 18 January 2021)
Abstract
Objective
To determine whether electronic health record alerts for acute kidney injury would improve patient outcomes of mortality, dialysis, and progression of acute kidney injury.
Design
Double bli...
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Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure
Olav L. Schjørring, Thomas L. Klitgaard, Anders Perner, et al
N Engl J Med January 20, 2021DOI: 10.1056/NEJMoa2032510
Abstract
BACKGROUND
Patients with acute hypoxemic respiratory failure in the intensive care unit (ICU) are treated with supplemental oxygen, but the benefits and harms of different oxygenation targets are unclear. We hypothesized that using a lower target for partial...
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ORIGINAL ARTICLE
Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19
Andre C. Kalil, Thomas F. Patterson, Aneesh K. Mehta, et al
N Engl J Med December 11, 2020DOI: 10.1056/NEJMoa2031994
Abstract
BACKGROUND
Severe coronavirus disease 2019 (Covid-19) is associated with dysregulated inflammation. The effects of combination treatment with baricitinib, a Janus kinase inhibitor, plus remdesivir are not known.
METHODS
We conducted a dou...
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CORRESPONDENCE|ONLINE FIRST
Infectivity of asymptomatic versus symptomatic COVID-19
Andrew A Sayampanathan, Cheryl S Heng, Phua Hwee Pin, et al
Lancet Published:December 18, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)32651-9
Asymptomatic cases of COVID-19 are a potential source of substantial spread within the community setting.1 However, little information is available about the infectivity and epidemiological significance of people with asymptomatic...
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ARTICLES|ONLINE FIRST
Ultra-early tranexamic acid after subarachnoid haemorrhage (ULTRA): a randomised controlled trial
René Post, Menno R Germans, Maud A Tjerkstra, et al.
Lancet Published:December 21, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)32518-6
Summary
Background
In patients with aneurysmal subarachnoid haemorrhage, short-term antifibrinolytic therapy with tranexamic acid has been shown to reduce the risk of rebleeding. However, whether this...
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ORIGINAL ARTICLE
Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
Lindsey R. Baden, Hana M. El Sahly, Brandon Essink, et al
N Engl J Med 2021; 384:403-416DOI: 10.1056/NEJMoa2035389
Abstract
BACKGROUND
Vaccines are needed to prevent coronavirus disease 2019 (Covid-19) and to protect persons who are at high risk for complications. The mRNA-1273 vaccine is a lipid nanoparticle–encapsulated mRNA-based vaccine that encodes the prefusion stabilized full...
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CORRESPONDENCE
Duration of Culturable SARS-CoV-2 in Hospitalized Patients with Covid-19
Min-Chul Kim, Chunguang Cui, Kyeong-Ryeol Shin, et al
N Engl J Med January 27, 2021DOI: 10.1056/NEJMc2027040
TO THE EDITOR:
The duration of transmissibility of coronavirus disease 2019 (Covid-19) and the associated level of contagion have been uncertain. We cultured severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in serial respiratory samples obtained from h...
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