Community-Acquired Pneumonia Visualized on CT Scans but Not Chest Radiographs: Pathogens, Severity, and Clinical Outcomes Cameron P. Upchurch, Carlos G. Grijalva, Richard G. Wunderink, et al. CHEST 2018; 153(3):601-610 BACKGROUND: 背景 The clinical significance of pneumonia visualized on CT scan in the setting of a normal chest radiograph is uncertain. 当胸片正常时，CT扫描可见的肺炎其临床意义并不明确。 METHODS: 方法 In a multicenter prospective surveillance study ...

Intensive Care Medicine ONLINE FIRST THIS WEEK (FREE ACCESS) Imaging in Intensive Care Medicine ~ DH. Merdji et al. Vertebral fracture as a complication of cardiopulmonary resuscitation. Letter ~ H. Erhan Dincer et al. The first report of safety and feasibility of transbronchial cryoprobe lung biopsy in ARDS. Seven-Day Profile Publication ~ Xavier Benoit D’Journo et al. Oropharyngeal and nasopharyngeal decontamination with chlorhexidine gluconate in lung cancer surgery: a ...

Original Research: Critical Care Histopathologic Findings in Lungs of Patients Treated With Extracorporeal Membrane Oxygenation Hee Eun Lee, Eunhee S. Yi, Jeffrey T. Rabatin, et al. CHEST 2018; 153(4):825-833 BACKGROUND: 背景 The outcome of extracorporeal membrane oxygenation (ECMO) might be influenced by its complications. Only limited information is available regarding the pathologic consequences of ECMO, especially in the era of modern ECMO technology. 接受ECMO治疗...

Simplifying the use of prognostic information in traumatic brain injury. Part 1: The GCS-Pupils score: an extended index of clinical severity Journal of Neurosurgery Posted online on April 10, 2018 Abstract OBJECTIVE 目的 Glasgow Coma Scale (GCS) scores and pupil responses are key indicators of the severity of traumatic brain damage. The aim of this study was to determine what information would be gained by combining these indicators into a single index and to explore th...

Intensive Care Medicine ONLINE FIRST THIS WEEK (FREE ACCESS) Editorial Debate ~ Djillali Annane et al. Are systematic reviews and meta-analyses still useful research? Yes. Editorial Debate ~ Sylvie Chevret et al. Are systematic reviews and meta-analyses still useful research? No. Editorial Debate ~ Morten Hylander Møller et al. Are systematic reviews and meta-analyses still useful research? We are not sure. What's New in Intensive Care ~ Akash Deep et al. Paediatric acute ...

Airway Pressure Release Ventilation in Pediatric Acute Respiratory Distress Syndrome: a Randomized Controlled Trial Saptharishi Lalgudi Ganesan, Muralidharan Jayashree, Sunit Chandra Singhi, et al Am J Respir Crit Care Med 2018 Published Online: April 11, 2018 https://doi.org/10.1164/rccm.201705-0989OC PubMed: 29641221 Rationale: 背景 Though case series describe benefits of Airway pressure release ventilation (APRV), this mo...

Multistate Outbreak of E. coli O157:H7 Infections Linked to Chopped Romaine Lettuce Posted April 13, 2018 2:00 PM EST 概要 病例数 35例 发病    11个州 死亡    0例 住院    22例 召回    无 Highlights Information collected to date indicates that chopped romaine lettuce from the Yuma, Arizona growing region could be contaminated with E. coli O157:H7 and could make people sick. At this time, no common grower, supplier, distributor, or brand has been identified. Adv...

Intensive Care Medicine ONLINE FIRST THIS WEEK (FREE ACCESS) Original ~ Fabiana Madotto et al. Resolved versus confirmed ARDS after 24h: Insights from the LUNG SAFE study. Seven-Day Profile Publication ~ Tobias Welte et al. Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomised, placebo-controlled, double-blind, multicentre, phase II trial (CIGMA study). What's New in Intensive Care ~ G...

Viewpoint April 10, 2018 The Proposal to Lower P Value Thresholds to .005 John P. A. Ioannidis JAMA. 2018;319(14):1429-1430. doi:10.1001/jama.2018.1536 P values and accompanying methods of statistical significance testing are creating challenges in biomedical science and other disciplines. The vast majority (96%) of articles that report P values in the abstract, full text, or both include some values of .05 or less.1 However, many of the claims that these reports highl...

ORIGINAL ARTICLE Two-Year Outcomes with a Magnetically Levitated Cardiac Pump in Heart Failure Mandeep R. Mehra, Daniel J. Goldstein, Nir Uriel, et al N Engl J Med 2018; 378:1386-1395 DOI: 10.1056/NEJMoa1800866 Abstract BACKGROUND 背景 In an early analysis of this trial, use of a magnetically levitated centrifugal continuous-flow circulatory pump was found to improve clinical outcomes, as compared with a mechanical-bearing axial continuous-flow pump, at 6 months in patient...