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Research Letter April 27, 2020 Exposure to a Surrogate Measure of Contamination From Simulated Patients by Emergency Department Personnel Wearing Personal Protective Equipment Oren Feldman, Michal Meir, Danielle Shavit, et al JAMA. 2020;323(20):2091-2093. doi:10.1001/jama.2020.6633 A major challenge with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is the effective protection of health care workers.1 Recommendations for t...
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ARTICLES|ONLINE FIRST Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial Feng-Cai Zhu, Yu-Hua Li, Xu-Hua Guan, et al Lancet Published:May 22, 2020 DOI: https://doi.org/10.1016/S0140-6736(20)31208-3 Summary Background A vaccine to protect against COVID-19 is urgently needed. We aimed to assess the safety, tolerability, and immunogenicity...
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Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis Mandeep R Mehra, Sapan S Desai, Frank Ruschitzka, et al Lancet Published Online May 22, 2020 https://doi.org/10.1016/S0140-6736(20)31180-6 Summary Background Hydroxychloroquine or chloroquine, often in combination with a second-generation macrolide, are being widely used for treatment of COVID-19, despite no conclusive evidence of their...
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ORIGINAL ARTICLE Remdesivir for the Treatment of Covid-19 — Preliminary Report John H. Beigel, Kay M. Tomashek, Lori E. Dodd, et al N Engl J Med May 22, 2020DOI: 10.1056/NEJMoa2007764 Abstract BACKGROUND Although several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 (Covid-19), none have yet been shown to be efficacious. METHODS We conducted a double-blind, randomized, placebo-controlled trial of intravenous r...
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CORRESPONDENCE Covid-19 and Kidney Transplantation NEJM April 24, 2020DOI: 10.1056/NEJMc2011117 TO THE EDITOR: Kidney-transplant recipients appear to be at particularly high risk for critical Covid-19 illness due to chronic immunosuppression and coexisting conditions.1 At Montefiore Medical Center, we identified 36 consecutive adult kidney-transplant recipients who tested positive for Covid-19 between March 16 and April 1, 2020. A total of 26 recipients (...
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Research Letter May 15, 2020 Use of Prone Positioning in Nonintubated Patients With COVID-19 and Hypoxemic Acute Respiratory Failure Xavier Elharrar, Youssef Trigui, Anne-Marie Dols, et al JAMA. Published online May 15, 2020. doi:10.1001/jama.2020.8255 Patients with coronavirus disease 2019 (COVID-19) are at risk for acute respiratory distress syndrome.1 In intubated patients with severe acute respiratory distress syndrome, early and prolonged (...
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April 14, 2020 Effect of Preemptive Therapy vs Antiviral Prophylaxis on Cytomegalovirus Disease in Seronegative Liver Transplant Recipients With Seropositive Donors: A Randomized Clinical Trial Nina Singh, Drew J. Winston, Raymund R. Razonable, et al. JAMA. 2020;323(14):1378-1387. doi:10.1001/jama.2020.3138 Abstract Importance Despite the use of a cytomegalovirus (CMV) prevention strategy of antiviral prophylaxis for high-risk CMV-seronegative ...
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Viewpoint April 6, 2020 The COVID-19 Pandemic in the USA: Clinical Update Saad B. Omer, Preeti Malani, Carlos del Rio JAMA. 2020;323(18):1767-1768. doi:10.1001/jama.2020.5788 Since the first US case of coronavirus disease 2019 (COVID-19) infection as identified in Washington State on January 20, 2020, more than 235 000 cases have been identified across the US in just over 2 months. Given the challenges in expanding testing capacity and the restrictive cas...
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Delayed versus early initiation of renal replacement therapy for severe acute kidney injury: a systematic review and individual patient data meta-analysis of randomised clinical trials Lancet 2020; 395: 1506-1515 Summary Background The timing of renal replacement therapy (RRT) for severe acute kidney injury is highly debated when no life-threatening complications are present. We assessed whether a strategy of delayed versus early RRT initiation affects 28-day ...
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CORRESPONDENCE Out-of-Hospital Cardiac Arrest during the Covid-19 Outbreak in Italy N Engl J Med April 29, 2020DOI: 10.1056/NEJMc2010418 TO THE EDITOR: Despite the risk of rapid respiratory failure1 and cardiac complications2 due to Covid-19, it is unclear whether there is an association between Covid-19 and out-of-hospital cardiac arrest. The Lombardy region of Italy was among the first areas to have an outbreak of Covid-19 outside China,3 and ...
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