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Research Drug treatments for covid-19: living systematic review and network meta-analysis BMJ 2020; 370: m2980 doi: https://doi.org/10.1136/bmj.m2980 (Published 30 July 2020) Abstract Objective To compare the effects of treatments for coronavirus disease 2019 (covid-19). Design Living systematic review and network meta-analysis. Data sources US Centers for Disease Control and Prevention COVID-19 Research Articles Downloadable Database, which inc...
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Research Effect of exercise training for five years on all cause mortality in older adults—the Generation 100 study: randomised controlled trial BMJ 2020; 371 doi: https://doi.org/10.1136/bmj.m3485 (Published 07 October 2020)Cite this as: BMJ 2020;371:m3485 Abstract Objective To evaluate the effect of five years of supervised exercise training compared with recommendations for physical activity on mortality in older adults (70-77 years). Design Ra...
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Original Investigation October 23, 2020 Effect of Regional Citrate Anticoagulation vs Systemic Heparin Anticoagulation During Continuous Kidney Replacement Therapy on Dialysis Filter Life Span and Mortality Among Critically Ill Patients With Acute Kidney Injury: A Randomized Clinical Trial Alexander Zarbock, Mira Küllmar, Detlef Kindgen-Milles, et al JAMA. 2020;324(16):1629-1639. doi:10.1001/jama.2020.18618 Abstract I...
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Research Convalescent plasma in the management of moderate covid-19 in adults in India: open label phase II multicentre randomised controlled trial (PLACID Trial) Anup Agarwal, Aparna Mukherjee, Gunjan Kumar, et al BMJ 2020; 371:m3939 doi: https://doi.org/10.1136/bmj.m3939 Abstract Objective To investigate the effectiveness of using convalescent plasma to treat moderate coronavirus disease 2019 (covid-19) in adults in India. Design Open label, para...
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ORIGINAL ARTICLE Efficacy of Tocilizumab in Patients Hospitalized with Covid-19 John H. Stone, Matthew J. Frigault, Naomi J. Serling-Boyd, et al N Engl J Med October 21, 2020DOI: 10.1056/NEJMoa2028836 BACKGROUND The efficacy of interleukin-6 receptor blockade in hospitalized patients with coronavirus disease 2019 (Covid-19) who are not receiving mechanical ventilation is unclear. METHODS We performed a randomized, double-blind, placebo-controlled tria...
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ARTICLES|ONLINE FIRST Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial RECOVERY Collaborative Group Lancet Published:October 05, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)32013-4 Summary 摘要 Background 背景 Lopinavir–ritonavir has been proposed as a treatment for COVID-19 on the basis of in vitro activity, preclinical studies, and observational studies. Here, we repo...
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ONLINE FIRST THIS WEEK(FREE ACCESS) Narrative Review ~ Logan C. et al. - Invasive candidiasis in critical care: challenges and future directions Correspondence ~ Bouhemad B.  et al. - Left ventricular diastolic dysfunction as a predictor of weaning failure from mechanical ventilation. Author’s reply Editorial ~ Finkenstedt A. et al. - Stress ulcer prophylaxis: Is mortality a useful endpoint? ...
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ARTICLES| VOLUME 20, ISSUE 9, P1025-1033, SEPTEMBER 01, 2020 Individual quarantine versus active monitoring of contacts for the mitigation of COVID-19: a modelling study Corey M Peak, Rebecca Kahn, Yonatan H Grad, et al Lancet Infect Dis 2020; 20: 1025-1033 Summary Background Voluntary individual quarantine and voluntary active monitoring of contacts are core disease control strategies for emerging infectious diseases such as COVID-19. Given the impact o...
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ICU Management & Practice, Volume 20 - Issue 3, 2020 Promising Techniques in Sepsis After Cardiac Surgery The purpose of this article is to give an up-to-date, comprehensive review on the utilisation of extracorporeal blood purification techniques and immunostimulation in septic patients after cardiac surgery. Introduction Sepsis is a potentially life-threatening state caused by an infection and an inadequate, dysregulated host immune response. In gen...
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2020 most popular articles in Critical Care Featured Reviews  Biomarkers in critical care nutrition The goal of nutrition support is to provide the substrates required to match the bioenergetic needs of the patient and promote the net synthesis of macromolecules required for the preservation of lean mass, organ function, and immunity. Optimization of nutrition delivery should thus improve ICU clinical outcomes. C. Stoppe et al. discuss the development of...
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