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LEVOSIMENDAN FOR THE PREVENTION OF ACUTE ORGAN DYSFUNCTION IN SEPSIS. Authors: Gordon AC, Perkins GD, Singer M et al. Reference: N Engl J Med 2016; 375:1638-1648 © Massachusetts Medical Society. ICM ABSTRACT Objective To investigate whether adding levosimendan to standard care reduces the severity of organ dysfunction in patients with septic shock and to assess its safety profile. Introduction Catecholamines are first-line therapy for septic shock, but high levels of circ...
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EFFECT OF HYDROCORTISONE ON DEVELOPMENT OF SHOCK AMONG PATIENTS WITH SEVERE SEPSIS: THE HYPRESS RANDOMIZED CLINICAL TRIAL. Authors: Keh D, Trips E, Marx G et al. Reference: JAMA 2016;316:1775–1785. © American Medical Association. Level of evidence: 2 ICM ABSTRACT Objective To determine whether hydrocortisone therapy in patients with severe sepsis prevents the development of septic shock. Introduction The rationale for the use of corticosteroids in the acute phase of septi...
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JAMA Clinical Guidelines Synopsis January 19, 2017 Management of Sepsis and Septic Shock Michael D. Howell, Andrew M. Davis JAMA. Published online January 19, 2017. doi:10.1001/jama.2017.0131 Guideline title Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 Developers Surviving Sepsis Campaign (SSC) Society of Critical Care Medicine (SCCM) European Society of Intensive Care Medicine (ESICM) Release date January 18, 201...
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Viewpoint | January 19, 2017 Surviving Sepsis Guidelines: A Continuous Move Toward Better Care of Patients With Sepsis Daniel De Backer, Todd Dorman JAMA. Published online January 19, 2017. doi:10.1001/jama.2017.0059 Sepsis is a life-threatening condition that affects more than 1 million patients a year in the United States and even more patients around the globe and is one of the leading causes of death. Since the Declaration of Barcelona in 2002, the European Societ...
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Editorial qSOFA for Identifying Sepsis Among Patients With Infection François Lamontagne, David A. Harrison, Kathryn M. Rowan JAMA. 2017;317(3):267-268. doi:10.1001/jama.2016.19684 The identification of patients with possible sepsis is vitally important because timely recognition and appropriate, effective treatment substantially improves survival. Unlike some other life-threatening conditions (such as myocardial infarction), for which highly accurate diagnostic tests ...
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[编者按]:随着新的拯救全身性感染行动临床实践指南2016的发布,很多同道纷纷以各种形式(包括社交媒体)进行介绍和评论,相信这对于了解指南的更新内容及其理由大有裨益。然而,与指南同时发表的其他文章同样也值得关注。 Practice Guidelines as Implementation Science: The Journal Editors’ Perspective* Timothy G. Buchman, MD, PhD, MCCM Editor-in-Chief, Critical Care Medicine Elie Azoulay, MD, PhD Editor-in-Chief, Intensive Care Medicine We are pleased to present the 2016 editio...
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Effect of a quality improvement intervention with daily round checklists, goal setting, and clinician prompting on mortality of critically ill patients: a randomized clinical trial. ICM Index Number: 23/070 Authors: Writing Group for the CHECKLIST-ICU Investigators and the Brazilian Research in Intensive Care Network (BRICNet) et al. Reference: JAMA 2016;315:1480–1490. Trial registration number: NCT01785966. © American Medical Association. ICM ABSTRACT Objective To det...
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Trial of decompressive craniectomy for traumatic intracranial hypertension. ICM Index Number: 23/069 Authors: Hutchinson PJ, Kolias AG, Timofeev IS et al. Reference: N Engl J Med 2016;375:1119–1130. Trial registration number: ISRCTN66202560. © Massachusetts Medical Society. ICM ABSTRACT Objective To assess the effectiveness of craniectomy as a last-tier intervention in patients with traumatic brain injury (TBI) and refractory intracranial hypertension. Introduction Int...
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Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial. ICM Index Number: 23/068 Authors: Su X, Meng ZT, Wu XH et al. Reference: Lancet 2016;388:1893-1902. Trial registration number: ChiCTR-TRC-10000802. © Elsevier Ltd. ICM ABSTRACT Objective To investigate whether prophylactic, low-dose dexmedetomidine could safely decrease the incidence of delirium in elderly patients admitted to ...
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Does Dexmedetomidine Reduce Delirium by Improving Sleep? Xian Su, MD; Dongxin Wang; MD ICU Management & Practice 2016; 16(4) Delirium is a common complication in intensive care unit (ICU) patients and its occurrence is associated with worse outcome (Inouye et al. 2014; Abelha et al. 2013). Sleep disturbances are considered one of the important risk factors of delirium development (Flink et al. 2012). Recent evidence shows that dexmedetomidine, either at sedative or n...
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