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[ICU Management & Practice]: 革兰阴性杆菌血流感染的多学科诊疗已关闭评论
Multidisciplinary Management of Gram-Negative Bloodstream Infections In ICU Tue, 12 Mar 2024 Bloodstream infections (BSIs) caused by Gram-negative pathogens pose significant challenges in ICU patients due to their high prevalence and severity, with mortality rates reported as high as 40%. The widespread prevalence of multidrug-resistant organisms (MDRO) further complicates antibiotic treatment choices, with mortality rates reaching 43% when MDROs are i...
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[ICU Management & Practice]: 评估呼吸肌肉预测脱机结局已关闭评论
Respiratory Muscle Assessments to Predict Weaning Outcomes In ICU Tue, 12 Mar 2024 Various factors influence failure to wean from mechanical ventilation, including respiratory muscle dysfunction, which is strongly associated with weaning failure and mortality. However, respiratory muscle function assessment is not routinely performed in most ICUs.  Various bedside tools are available for assessing respiratory muscle function, including non-voli...
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[ICU Management & Practice]: 手术室过渡到ICU期间的呼吸机参数已关闭评论
Ventilator Parameters During OR–to–ICU Transition In ICU Tue, 5 Mar 2024 Lung-protective mechanical ventilation strategies are beneficial both in the operating room (OR) and the ICU. However, there are variations in ventilator management practices between these settings, leading to adjustments in ventilator parameters when patients transition from the OR to the ICU. The impact of changes in ventilator settings during transitions between these settings ...
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[ICU Management & Practice]: 针对ICU医务人员的暴力已关闭评论
Violence Against Healthcare Professionals in ICUs In ICU Tue, 5 Mar 2024 A new study reviewed existing literature on workplace violence (WPV) against healthcare workers (HCWs) in ICUs, focusing on prevalence, risk factors, interventions, and preventive measures. WPV, defined as violent acts or threats directed towards individuals at work, is a significant issue globally, with HCWs experiencing a 20% higher rate compared to other employees. However, WPV...
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[ICU Management & Practice]: ICU中重要器官支持治疗的性别差异已关闭评论
Sex Differences in Vital Organ Support in ICU There is increasing evidence that factors such as sex, race, and socioeconomic status may influence the treatment received in ICUs. Data suggests that women are less likely to receive invasive ventilation, vasoactive medication, renal replacement therapy (RRT), extracorporeal membrane oxygenation (ECMO), and tracheostomy than men, but previous studies have shown heterogeneity and risk of bias. Factors like illness sever...
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[JAMA发表述评]:在患者共享网络中控制耐药菌已关闭评论
Editorial  April 1, 2024 Controlling Multidrug-Resistant Organisms Across Patient-Sharing Networks Christopher J. Crnich JAMA. Published online April 1, 2024. doi:10.1001/jama.2024.0267 Antimicrobial resistance is a major public health problem that threatens to reverse many of the medical therapy advances achieved over the past 4 decades.1 Infections caused by multidrug-resistant organisms (MDROs) are estimated to cause 35000 deaths in t...
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[ICU Management & Practice]: 60年来科学家首次发现新的抗生素已关闭评论
Scientists Discover First New Antibiotic in Six Decades A ground-breaking class of antibiotics targeting drug-resistant Staphylococcus aureus (MRSA) bacteria has been discovered by applying transparent deep-learning models in medicine. Artificial intelligence (AI) is revolutionising the field, aiding scientists in unveiling the first novel antibiotics in six decades. Designated a priority-one critical pathogen by the World Health Organization, this organism has ...
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[ICU Management & Practice]: 有关高风险药物联合使用的计算机决策支持提醒已关闭评论
Computerised Decision Support Alerts for High-Risk Drug Combinations Existing clinical decision support systems (CDSSs) designed to prevent drug-drug interaction (DDI) often generate low-yield alerts, leading to alert fatigue among physicians and jeopardising patient safety.  A recent study focuses on the impact of tailoring DDI alerts to the ICU setting to reduce the frequency of high-risk drug combinations. The multicentre study aims to assess how customising...
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[ICU Management & Practice]: 解码脓毒症的细胞因子风暴已关闭评论
Decoding the Cytokine Storm in Sepsis Sepsis is a prominent cause of mortality in ICUs. Despite extensive research on the dynamics leading to sepsis, the role of cytokines—immune system molecules that can cause substantial harm to the body—has remained inadequately understood. While these proteins typically regulate inflammation, an overly aggressive immune response can result in a cytokine storm, leading to tissue damage, organ failure, and, ultimately, death. ...
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[JAMA发表述评]:疫苗上市后安全性评价:重要的工作正在进行中已关闭评论
Editorial  March 19, 2024 Postmarketing Vaccine Safety Assessments: Important Work in Progress Kathryn M. Edwards, Marie R. Griffin JAMA. 2024;331(11):915-917. doi:10.1001/jama.2023.26630 After the initial randomized clinical trials and emergency use authorization of the COVID-19 vaccines by the US Food and Drug Administration (FDA) during the COVID-19 pandemic, the US Centers for Disease Control and Prevention (CDC) and the FDA undertook ext...
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