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Editorial March 21, 2017 Optimizing the Settings on the Ventilator Settings: High PEEP for All? Ary Serpa Neto, Marcus J. Schultz JAMA. Published online March 21, 2017. doi:10.1001/jama.2017.2570 Mechanical ventilation is an effective life-support technique widely deployed across a variety of clinical settings in the care of many millions of patients each year worldwide. However, it is not a panacea. A central issue is that artificial ventilation works by pushing air ...
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EMPIRICAL MICAFUNGIN TREATMENT AND SURVIVAL WITHOUT INVASIVE FUNGAL INFECTION IN ADULTS WITH ICU-ACQUIRED SEPSIS, CANDIDA COLONIZATION, AND MULTIPLE ORGAN FAILURE: 
THE EMPIRICUS RANDOMIZED CLINICAL TRIAL. Authors: Timsit JF, Azoulay E, Schwebel C, et al. Reference: JAMA 2016;316:1555–1564. © American Medical Association. Level of evidence: 2 ICM ABSTRACT Objective To determine the effect of empirical micafungin treatment on survival without an invasive fungal infection i...
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Medscape Critical Care > Critical Issues How to Interpret a Diffusion Capacity of the Lung for Carbon Monoxide Aaron B. Holley, MD March 07, 2017 Background The diffusion capacity of the lung for carbon monoxide (DLCO) is used to measure the body's ability to transfer oxygen across the alveolar-capillary membrane. [1] Internists use this test to identify interstitial lung disease, oncologists order it to assess the effects of chemotherapy, and pulmonologists use it f...
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EPIDEMIOLOGY OF ACUTE KIDNEY INJURY IN CRITICALLY ILL CHILDREN AND YOUNG ADULTS. Authors: Kaddourah A, Basu RK, Bagshaw SM, Goldstein SL for the AWARE Investigators. Reference: N Engl J Med, 2017; 376: 11-20 © Massachusetts Medical Society. Level of evidence: 4 ICM ABSTRACT Objective To define the incremental risk of death and complications associated with severe acute kidney injury (AKI) in critically ill children and young adults. Introduction In adult patients, AKI is ...
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LEVOSIMENDAN FOR THE PREVENTION OF ACUTE ORGAN DYSFUNCTION IN SEPSIS. Authors: Gordon AC, Perkins GD, Singer M et al. Reference: N Engl J Med 2016; 375:1638-1648 © Massachusetts Medical Society. ICM ABSTRACT Objective To investigate whether adding levosimendan to standard care reduces the severity of organ dysfunction in patients with septic shock and to assess its safety profile. Introduction Catecholamines are first-line therapy for septic shock, but high levels of circ...
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EFFECT OF HYDROCORTISONE ON DEVELOPMENT OF SHOCK AMONG PATIENTS WITH SEVERE SEPSIS: THE HYPRESS RANDOMIZED CLINICAL TRIAL. Authors: Keh D, Trips E, Marx G et al. Reference: JAMA 2016;316:1775–1785. © American Medical Association. Level of evidence: 2 ICM ABSTRACT Objective To determine whether hydrocortisone therapy in patients with severe sepsis prevents the development of septic shock. Introduction The rationale for the use of corticosteroids in the acute phase of septi...
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JAMA Clinical Guidelines Synopsis January 19, 2017 Management of Sepsis and Septic Shock Michael D. Howell, Andrew M. Davis JAMA. Published online January 19, 2017. doi:10.1001/jama.2017.0131 Guideline title Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 Developers Surviving Sepsis Campaign (SSC) Society of Critical Care Medicine (SCCM) European Society of Intensive Care Medicine (ESICM) Release date January 18, 201...
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Viewpoint | January 19, 2017 Surviving Sepsis Guidelines: A Continuous Move Toward Better Care of Patients With Sepsis Daniel De Backer, Todd Dorman JAMA. Published online January 19, 2017. doi:10.1001/jama.2017.0059 Sepsis is a life-threatening condition that affects more than 1 million patients a year in the United States and even more patients around the globe and is one of the leading causes of death. Since the Declaration of Barcelona in 2002, the European Societ...
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Editorial qSOFA for Identifying Sepsis Among Patients With Infection François Lamontagne, David A. Harrison, Kathryn M. Rowan JAMA. 2017;317(3):267-268. doi:10.1001/jama.2016.19684 The identification of patients with possible sepsis is vitally important because timely recognition and appropriate, effective treatment substantially improves survival. Unlike some other life-threatening conditions (such as myocardial infarction), for which highly accurate diagnostic tests ...
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[编者按]:随着新的拯救全身性感染行动临床实践指南2016的发布,很多同道纷纷以各种形式(包括社交媒体)进行介绍和评论,相信这对于了解指南的更新内容及其理由大有裨益。然而,与指南同时发表的其他文章同样也值得关注。 Practice Guidelines as Implementation Science: The Journal Editors’ Perspective* Timothy G. Buchman, MD, PhD, MCCM Editor-in-Chief, Critical Care Medicine Elie Azoulay, MD, PhD Editor-in-Chief, Intensive Care Medicine We are pleased to present the 2016 editio...
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