Recommended Reading from the NewYork-Presbyterian Hospital – Weill Cornell Medicine Pulmonary and Critical Care Medicine Fellows Kevin C. Ma, Daniel S. Jones, David R. Price, et al AJRCCM Articles in Press. Published on 13-March-2017 as 10.1164/rccm.201612-2478RR Neto AS, et al. Associations between ventilator settings during extracorporeal membrane oxygenation for refractory hypoxemia and outcome in patients with acute respiratory distress syndrome: a pooled individual pa...

Recommended Reading from the NewYork-Presbyterian Hospital – Weill Cornell Medicine Pulmonary and Critical Care Medicine Fellows Kevin C. Ma, Daniel S. Jones, David R. Price, et al AJRCCM Articles in Press. Published on 13-March-2017 as 10.1164/rccm.201612-2478RR Dickson et al. Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome. Nat Microbio (8) Reviewed by Daniel S. Jones Acute respiratory distress syndrome (ARDS) is...

Recommended Reading from the NewYork-Presbyterian Hospital – Weill Cornell Medicine Pulmonary and Critical Care Medicine Fellows Kevin C. Ma, Daniel S. Jones, David R. Price, et al AJRCCM Articles in Press. Published on 13-March-2017 as 10.1164/rccm.201612-2478RR Kor DJ. Effect of Aspirin on Development of ARDS in At-Risk Patients Presenting to the Emergency Department: The LIPS-A Randomized Clinical Trial. JAMA (1) Reviewed by Kevin C. Ma Acute respiratory distress syndr...

Editorial March 21, 2017 Optimizing the Settings on the Ventilator Settings: High PEEP for All? Ary Serpa Neto, Marcus J. Schultz JAMA. Published online March 21, 2017. doi:10.1001/jama.2017.2570 Mechanical ventilation is an effective life-support technique widely deployed across a variety of clinical settings in the care of many millions of patients each year worldwide. However, it is not a panacea. A central issue is that artificial ventilation works by pushing air ...

EMPIRICAL MICAFUNGIN TREATMENT AND SURVIVAL WITHOUT INVASIVE FUNGAL INFECTION IN ADULTS WITH ICU-ACQUIRED SEPSIS, CANDIDA COLONIZATION, AND MULTIPLE ORGAN FAILURE: 
THE EMPIRICUS RANDOMIZED CLINICAL TRIAL. Authors: Timsit JF, Azoulay E, Schwebel C, et al. Reference: JAMA 2016;316:1555–1564. © American Medical Association. Level of evidence: 2 ICM ABSTRACT Objective To determine the effect of empirical micafungin treatment on survival without an invasive fungal infection i...

Medscape Critical Care > Critical Issues How to Interpret a Diffusion Capacity of the Lung for Carbon Monoxide Aaron B. Holley, MD March 07, 2017 Background The diffusion capacity of the lung for carbon monoxide (DLCO) is used to measure the body's ability to transfer oxygen across the alveolar-capillary membrane. [1] Internists use this test to identify interstitial lung disease, oncologists order it to assess the effects of chemotherapy, and pulmonologists use it f...

EPIDEMIOLOGY OF ACUTE KIDNEY INJURY IN CRITICALLY ILL CHILDREN AND YOUNG ADULTS. Authors: Kaddourah A, Basu RK, Bagshaw SM, Goldstein SL for the AWARE Investigators. Reference: N Engl J Med, 2017; 376: 11-20 © Massachusetts Medical Society. Level of evidence: 4 ICM ABSTRACT Objective To define the incremental risk of death and complications associated with severe acute kidney injury (AKI) in critically ill children and young adults. Introduction In adult patients, AKI is ...

LEVOSIMENDAN FOR THE PREVENTION OF ACUTE ORGAN DYSFUNCTION IN SEPSIS. Authors: Gordon AC, Perkins GD, Singer M et al. Reference: N Engl J Med 2016; 375:1638-1648 © Massachusetts Medical Society. ICM ABSTRACT Objective To investigate whether adding levosimendan to standard care reduces the severity of organ dysfunction in patients with septic shock and to assess its safety profile. Introduction Catecholamines are first-line therapy for septic shock, but high levels of circ...

EFFECT OF HYDROCORTISONE ON DEVELOPMENT OF SHOCK AMONG PATIENTS WITH SEVERE SEPSIS: THE HYPRESS RANDOMIZED CLINICAL TRIAL. Authors: Keh D, Trips E, Marx G et al. Reference: JAMA 2016;316:1775–1785. © American Medical Association. Level of evidence: 2 ICM ABSTRACT Objective To determine whether hydrocortisone therapy in patients with severe sepsis prevents the development of septic shock. Introduction The rationale for the use of corticosteroids in the acute phase of septi...

JAMA Clinical Guidelines Synopsis January 19, 2017 Management of Sepsis and Septic Shock Michael D. Howell, Andrew M. Davis JAMA. Published online January 19, 2017. doi:10.1001/jama.2017.0131 Guideline title Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 Developers Surviving Sepsis Campaign (SSC) Society of Critical Care Medicine (SCCM) European Society of Intensive Care Medicine (ESICM) Release date January 18, 201...