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The 10 false beliefs in adult critical care nephrology Zaccaria Ricci, Stefano Romagnoli, Claudio Ronco Intensive Care Med 2018; 44: 1302-1305 1. Acute tubular necrosis is the main histopathologic finding in AKI 急性肾小管坏死是AKI的主要组织病理学表现 Acute tubular necrosis (ATN), a histological pattern observed after ischemic insult, is considered the most frequent cause of any form of acute kidney injury (AKI) despite the absence of extensive histological data. This bel...
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Inspiratory muscle training for ICU patients: first practical guide Inspiratory muscle weakness is a known consequence of prolonged mechanical ventilation, and there is emerging evidence that specific inspiratory muscle training (IMT) can ameliorate this weakness. Australian researchers recommend a multidisciplinary approach to IMT for patients in the intensive care unit (ICU).    "Effective IMT requires a multidisciplinary approach to maximise feasibility, with doctors, ...
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Practice Rapid Recommendations Corticosteroid therapy for sepsis: a clinical practice guideline Francois Lamontagne, Bram Rochwerg, Lyubov Lytvyn, et al. BMJ 2018; 362: k3284 doi: https://doi.org/10.1136/bmj.k3284        
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ORIGINAL ARTICLE Closed-Loop Insulin Delivery for Glycemic Control in Noncritical Care Lia Bally, Hood Thabit, Sara Hartnell, et al N Engl J Med 2018; 379:547-556 DOI: 10.1056/NEJMoa1805233 Abstract BACKGROUND 背景 In patients with diabetes, hospitalization can complicate the achievement of recommended glycemic targets. There is increasing evidence that a closed-loop delivery system (artificial pancreas) can improve glucose control in patients with type 1 diabetes. We want...
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Articles Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: a randomised trial Hunter B Moore, Ernest E Moore, Michael P Chapman, et al Lancet 2018; 392: 283-291 Summary Background 背景 Plasma is integral to haemostatic resuscitation after injury, but the timing of administration remains controversial. Anticipating approval of lyophilised plasma by the US Food and Drug Administration, the US Department of Defe...
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ORIGINAL ARTICLE A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus Wiebke Fenske, Julie Refardt, Irina Chifu, et al N Engl J Med 2018; 379:428-439 DOI: 10.1056/NEJMoa1803760 Abstract BACKGROUND 背景 The indirect water-deprivation test is the current reference standard for the diagnosis of diabetes insipidus. However, it is technically cumbersome to administer, and the results are often inaccurate. The current study compared the indirect water-deprivation tes...
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CORRESPONDENCE Mobile Automated External Defibrillator Response System during Road Races Tomoya Kinoshi, Shota Tanaka, Ryo Sagisaka, et al N Engl J Med 2018; 379:488-489 DOI: 10.1056/NEJMc1803218 TO THE EDITOR: The number of marathon races and other road races has rapidly increased in Japan,1 as have the number of sudden cardiac arrests during these races.2 We developed a rapid mobile automated external defibrillator (AED) system to provide early cardiopulmonary resuscitat...
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ORIGINAL ARTICLE Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock Jason L. Sperry, Francis X. Guyette, Joshua B. Brown, et al N Engl J Med 2018; 379:315-326 DOI: 10.1056/NEJMoa1802345 Abstract BACKGROUND 背景 After a person has been injured, prehospital administration of plasma in addition to the initiation of standard resuscitation procedures in the prehospital environment may reduce the risk of downstream complications from...
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Original Investigation July 24/31, 2018 Association Between the New York Sepsis Care Mandate and In-Hospital Mortality for Pediatric Sepsis Idris V. R. Evans, Gary S. Phillips, Elizabeth R. Alpern, et al JAMA. 2018;320(4):358-367. doi:10.1001/jama.2018.9071 Abstract Importance 背景 The death of a pediatric patient with sepsis motivated New York to mandate statewide sepsis treatment in 2013. The mandate included a 1-hour bundle of blood cultures, broad-spectrum antibi...
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JAMA Clinical Evidence Synopsis July 19, 2018 Probiotics to Prevent Clostridium difficile Infection in Patients Receiving Antibiotics Joshua Z. Goldenberg, Dominik Mertz, Bradley C. Johnston JAMA. Published online July 19, 2018. doi:10.1001/jama.2018.9064 Clinical Question In adults and children prescribed antibiotics, is co-administration of a probiotic associated with a lower risk of symptomatic Clostridium difficileinfection without an increase in adverse events? ...
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