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Intensive Care Medicine ONLINE FIRST THIS WEEK (FREE ACCESS) Imaging in Intensive Care Medicine ~ Paul Gabarre et al. An acute dyspnea. Letter ~ Laëtitia Bodet-Contentin et al. Eye-tracking and speech-generating technology to improve communication with intubated intensive care unit patients: initial experience. Imaging in Intensive Care Medicine ~ Tobias Gonzenbach et al. Accidental placement of a dialysis catheter into the accessory hemiazygos vein. Letter ~ Néstor Pistil...
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Influenza Strikes Again: 100 Years After Great Pandemic Steven Rourke | February 9, 2018 Image courtesy of the National Archives The Great Influenza of 1918-1919 Occurring in three distinct waves[1-4] at the tail end of World War I, the Great Influenza was the most lethal influenza pandemic in history, which, worldwide, is believed to have killed approximately 50 million people[1-3]—although estimates of numbers of victims range from 20 million to 100 million.[1,2,4] Influ...
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JAMA Clinical Guidelines Synopsis February 20, 2018 Management of ARDS in Adults Michael D. Howell, Andrew M. Davis JAMA. 2018;319(7):711-712. doi:10.1001/jama.2018.0307 Guideline title 指南标题 Mechanical Ventilation in Adult Patients With Acute Respiratory Distress Syndrome 成年ARDS患者机械通气 Developer 指南制定者 American Thoracic Society (ATS)/European Society of Intensive Care Medicine (ESICM)/Society of Critical Care Medicine (SCCM) 美国胸科学会(ATS)/欧洲重症医...
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Comment & Response February 13, 2018 Early Resuscitation for Adults With Sepsis in a Low-income Country—Reply Matthew W. Semler, Ben Andrews, Gordon R. Bernard JAMA. 2018;319(6):614-615. doi:10.1001/jama.2017.20410 In Reply 回复 Drs Nedel and Deutschendorf highlight 2 key considerations for the interpretation of our trial and the management of patients with sepsis across settings: (1) timing of antibiotic administration and (2) volume of intravenous fluid. Nedel和D...
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Original Investigation February 13, 2018 Effect of the Pulmonary Embolism Rule-Out Criteria on Subsequent Thromboembolic Events Among Low-Risk Emergency Department PatientsThe PROPER Randomized Clinical Trial Yonathan Freund, MD, Marine Cachanado, Adeline Aubry, et al JAMA. 2018;319(6):559-566. doi:10.1001/jama.2017.21904 Abstract Importance 背景 The safety of the pulmonary embolism rule-out criteria (PERC), an 8-item block of clinical criteria aimed at ruling out pu...
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ORIGINAL ARTICLE Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine Steven D. Weisbord, Martin Gallagher, Hani Jneid, et al N Engl J Med 2018; 378:603-614 DOI: 10.1056/NEJMoa1710933 Abstract BACKGROUND 背景 Intravenous sodium bicarbonate and oral acetylcysteine are widely used to prevent acute kidney injury and associated adverse outcomes after angiography without definitive evidence of their efficacy. 静脉碳酸氢钠及口服乙酰半胱氨酸广泛用于预防血管造影后...
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Balanced Crystalloids versus Saline in Noncritically Ill Adults Wesley H. Self, Matthew W. Semler, Jonathan P. Wanderer, et al N Engl J Med February 27, 2018 DOI: 10.1056/NEJMoa1711586 Abstract BACKGROUND 背景 Comparative clinical effects of balanced crystalloids and saline are uncertain, particularly in noncritically ill patients cared for outside an intensive care unit (ICU). 平衡盐溶液与生理盐水临床疗效的比较结果尚不确切,尤其在ICU之外的非危重病患者。 METHODS 方法 We co...
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Intensive Care Medicine ONLINE FIRST THIS WEEK (FREE ACCESS) From the Inside ~ Erwin J. O. Kompanje. Burnout, boreout and compassion fatigue on the ICU: it is not about work stress, but about lack of existential significance and professional performance. Conference Reports and Expert Panel  ~ Darryl Abrams et al. Position paper for the organisation of ECMO programs for cardiac failure in adults. Original ~ Jean-Louis Vincent et al. Comparison of European ICU patients in 20...
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CC Nerd - The Case of the Relative Insufficiency January 20, 2018 by Rory Spiegel from https://emcrit.org/emnerd/cc-nerd-case-relative-insufficiency/ When it comes to the efficacy of glucocorticoid therapy for the treatment of septic shock, we have existed in a state of ambiguity, torn between the results of two contradictory RCTs. The first, the Annane et al trial published in JAMA in 2002, suggested a mortality benefit in favor of the corticosteroid group in the subset o...
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Balanced Crystalloids versus Saline in Critically Ill Adults Matthew W. Semler, Wesley H. Self, Jonathan P. Wanderer, et al N Engl J Med February 27, 2018 DOI: 10.1056/NEJMoa1711584 Abstract BACKGROUND 背景 Both balanced crystalloids and saline are used for intravenous fluid administration in critically ill adults, but it is not known which results in better clinical outcomes. 平衡盐溶液及生理盐水均可用于成年危重病患者的静脉输液治疗,但对临床结局的影响尚不清楚。 METHODS 方...
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