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Perspective > Viewpoints COMMENTARY In COPD, Are Sepsis Outcomes Better When a Bronchodilator Doubles as an Anti-inflammatory? Nicholas Gross, MD, PhD October 26, 2017 Association of Pre-hospital Theophylline Use and Mortality in Chronic Obstructive Pulmonary Disease Patients With Sepsis Shih YN, Chen YT, Chu H, et al Respir Med. 2017;125:33-38 Introduction 背景 Sepsis is a life-threatening disorder, and data show that its incidence doubled from 2000 through 200...
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Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2) Jean Reignier, Julie Boisramé-Helms, Laurent Brisard, et al Lancet Published: 08 November 2017 DOI: http://dx.doi.org/10.1016/S0140-6736(17)32146-3 Summary Background 背景 Whether the route of early feeding affects outcomes of patients with severe critical illnesses is controversial. We hypothesised that outcome...
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Aortic Dissection Lars Grimm, MD, MHS | October 30, 2017 | Contributor Information image from Medscape. An aortic dissection (arrows) is demonstrated above. The sudden onset of tearing chest pain may be the initial presentation of an acute aortic dissection. A small tear in the aortic intima can quickly split the aortic wall and create a swiftly expanding false lumen, which may be rapidly fatal even with prompt medical treatment. Image from Medscape. A false lumen (yello...
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Perspective > Viewpoints COMMENTARY Can Ganciclovir Thwart CMV Reactivation in Critical Illness? Greg Martin, MD October 30, 2017 CMV Reactivation: Can It Be Reduced? CMV复燃:能否减少? Cytomegalovirus (CMV) is a widely prevalent human herpes virus found in most healthy adults and causes lifelong latent infection in many organs, such as the lung. Latent CMV commonly reactivates during immunosuppression or critical illness, and research shows an association of CMV...
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Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial Sandra van Brunschot, Janneke van Grinsven, Hjalmar C van Santvoort, et al. Lancet 2017 epub ahead of print DOI: http://dx.doi.org/10.1016/S0140-6736(17)32404-2 Summary Background 背景 Infected necrotising pancreatitis is a potentially lethal disease and an indication for invasive intervention. The surgical step-up approach is the standard treatment. A promisin...
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Drugs & Diseases > Clinical Trends Clinical Trends for October 2017 Ryan Syrek October 27, 2017 Each week, we identify one top search term, speculate as to what caused its popularity, and provide an infographic on a related condition. If you have thoughts about what's trending and why, feel free to share them with us on Twitter or Facebook! Clinical Trend of the Week (October 21-27): Viral Encephalitis Several pieces of news from around the world combined to infl...
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SYNAPSE-ICU STUDY: REGISTER YOUR UNIT! Dear Colleague, SYNAPSE-ICU - An international prospective observational StudY on iNtrAcranial PreSsurE in intensive care (ICU) study, an initiative from the ESICM NIC Section, was recently awarded by the ESICM Trials Group and has now officially launched. This important observational study aims to explore ICP monitoring variation in practice in order to prioritise uncertainties in the clinical management of critical care patients wi...
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ORIGINAL ARTICLE PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock Holger Thiele, Ibrahim Akin, Marcus Sandri, et al N Engl J Med 2017 October 30, 2017DOI: 10.1056/NEJMoa1710261 BACKGROUND 背景 In patients who have acute myocardial infarction with cardiogenic shock, early revascularization of the culprit artery by means of percutaneous coronary intervention (PCI) improves outcomes. However, the majority of patients with cardiogenic shock ha...
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News > Conference News Landmark Trials Deliver Evidence to Rethink Saline Use Ingrid Hein November 02, 2017 TORONTO — Hospitalized patients who receive balanced crystalloid fluids, whether they are critically ill or not, are about 1% less likely to need renal replacement therapy, have persistent renal dysfunction, or die in the hospital than patients who receive saline, two new landmark studies show. 多伦多 - 两项新的重要研究显示,与生理盐水相比,接受平衡盐溶液的...
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Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbα antagonism: a single-centre propensity-matched cohort study and a randomised study David Montaigne, Xavier Marechal, Thomas Modine, et al. Lancet 2017 http://dx.doi.org/10.1016/S0140-6736(17)32132-3 Background 背景 On-pump cardiac surgery provokes a predictable perioperative myocardial ischaemia–reperfusion injury which is associated with poor clinical outcomes. We de...
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