Repair of Acute Respiratory Distress Syndrome in COVID-19 by Stromal Cells (REALIST-COVID Trial): A Multicenter, Randomized, Controlled Clinical Trial Ellen A. Gorman,  Jennifer Rynne,  Hannah J. Gardiner, et al Am J Respir Crit Care Med 2023; 208: 256-269 Abstract Rationale: Mesenchymal stromal cells (MSCs) may modulate inflammation, promoting repair in coronavirus disease (COVID-19)–related acute respiratory distress syndrome (ARDS). Objectives: ...

ICU Management & Practice, Volume 22 - Issue 5, 2022 Bedside Point-of-Care Ultrasound Use in the Critically Ill Historical Perspectives and a Path Forward Critical Care Ultrasound is a rapidly evolving field with an ever-expanding footprint in ICUs. While much progress has been made, ongoing efforts need to continue towards demonstrating impact on patient-oriented outcome measures and on defining educational curricula and competency requirements. Poin...

Viral-associated Pulmonary Aspergillosis: Have We Finally Overcome the Debate of Colonization versus Infection? Werner C. Albrich and  Frédéric Lamoth Am J Respir Crit Care Med 2023; 208: 230-231 Invasive pulmonary aspergillosis (IPA) has emerged in the ICU setting following the recent influenza H1N1 and coronavirus disease (COVID-19) pandemics. Viral-associated IPA (VAPA) is quite different than classical IPA in terms of pathogenicity and clinical presentation i...

A Pathology-based Case Series of Influenza- and COVID-19–associated Pulmonary Aspergillosis: The Proof Is in the Tissue Lore Vanderbeke,  Cato Jacobs,  Simon Feys, et al Am J Respir Crit Care Med 2023; 208: 301-311 Abstract Rationale: Invasive pulmonary aspergillosis has emerged as a frequent coinfection in severe coronavirus disease (COVID-19), similarly to influenza, yet the clinical invasiveness is more debated. Objectives: We investigated the ...

ICU Management & Practice, Volume 23 - Issue 2, 2023 Early Mobilisation in Patients Undergoing Extracorporeal Membrane Oxygenation Extracorporeal membrane oxygenation is a resource that is accessible in hospitals and intensive care units all over the world. In serious situations, ECMO therapy is intended to provide haemodynamic and/or ventilatory support. Because of this, many people refer to the ECMO patient as "the most critical patient." As a result, the...

ARTICLES| VOLUME 5, ISSUE 8, E461-E473, AUGUST 2023Download Full Issue Antibody prevalence after three or more COVID-19 vaccine doses in individuals who are immunosuppressed in the UK: a cross-sectional study from MELODY Fiona A Pearce, Sean H Lim, Mary Bythell, et al Lancet Rheumatol 2023; 5: E461-E473 Published:August, 2023 DOI:https://doi.org/10.1016/S2665-9913(23)00160-1 Summary Background In the UK, additional COVID-19 vaccine booster...

ARTICLES| VOLUME 22, ISSUE 8, P685-711, AUGUST 2023Download Full Issue Global, regional, and national burden of meningitis and its aetiologies, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 GBD 2019 Meningitis Antimicrobial Resistance Collaborators Lancet Neurol 2023; 22: 685-711 Published:August, 2023 DOI:https://doi.org/10.1016/S1474-4422(23)00195-3 Summary Background Although meningitis is largely preventable, it still c...

COMMENT|ONLINE FIRST Ultra-low tidal volume ventilation for lung protection: not so fast Laura A Buiteman-Kruizinga, Marcus J Schultz Lancet Respir Med Published:July 12, 2023DOI:https://doi.org/10.1016/S2213-2600(23)00225-4 Since 2000, following the publication of the ARMA study,1 low tidal volume (VT) ventilation (LTV) has been the standard of care for patients with acute respiratory distress syndrome (ARDS). LTV often refers to ventilation with VT of 6·0 mL...

ICU Management & Practice, Volume 23 - Issue 2, 2023 Predictive Analytics for Kidney Support in the ICU The timing and application of dialysis in the ICU is highly variable contributing to poor outcomes. A clinical decision support system (CDSS) incorporating a dynamic predictive algorithm for organ support could improve outcomes. Background Multiorgan failure (MOF) and acute kidney injury (AKI) are frequently encountered in critically ill patients an...

ARTICLES| VOLUME 4, ISSUE 8, E632-E641, AUGUST 2023Download Full Issue Viral and antibody dynamics of acute infection with SARS-CoV-2 omicron variant (B.1.1.529): a prospective cohort study from Shenzhen, China Yang Yang, Liping Guo, Jing Yuan, et al Lancet Microbe 2023; 8: E632-E641 Published:July 14, 2023 DOI:https://doi.org/10.1016/S2666-5247(23)00139-8 Summary Background Elucidating viral dynamics within the host is important for desig...