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Intensive Care Medicine ONLINE FIRST (FREE ACCESS)  Review~ Jean-François Timsit - Rationalizing antimicrobial therapy in the ICU: a narrative review Original~ Christophe Guitton - Nasal high-flow preoxygenation for endotracheal intubation in the critically ill patient: a randomized clinical trial Original~ Stefan J. Schaller - Influence of the initial level of consciousness on early, goal-directed mobilization: a post hoc analysis Imaging in Intensive Care Me...
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Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial Michael A Matthay, Carolyn S Calfee, Hanjing Zhuo, et al Lancet Respir Med 2019; 7: 154-162 Background 背景 Treatment with bone-marrow-derived mesenchymal stromal cells (MSCs) has shown benefits in preclinical models of acute respiratory distress syndrome (ARDS). Safety has not been established fo...
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Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial The ELFIN trial investigators group Lancet Published: January 08, 2019 Summary Background 背景 Infections acquired in hospital are an important cause of morbidity and mortality in very preterm infants. Several small trials have suggested that supplementing the enteral diet of very preterm infants with lactoferrin, an antimicrobial protein processed from cow's...
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ORIGINAL ARTICLE Randomized Trial of Platelet-Transfusion Thresholds in Neonates Anna Curley, Simon J. Stanworth, Karen Willoughby, et al N Engl J Med 2019; 380:242-251DOI: 10.1056/NEJMoa1807320 Abstract BACKGROUND 背景 Platelet transfusions are commonly used to prevent bleeding in preterm infants with thrombocytopenia. Data are lacking to provide guidance regarding thresholds for prophylactic platelet transfusions in preterm neonates with severe thrombo...
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Original Investigation January 29, 2019 Effect of Hydrocortisone Therapy Initiated 7 to 14 Days After Birth on Mortality or Bronchopulmonary Dysplasia Among Very Preterm Infants Receiving Mechanical Ventilation: A Randomized Clinical Trial Wes Onland, Filip Cools, Andre Kroon, et al JAMA. 2019;321(4):354-363. doi:10.1001/jama.2018.21443 Abstract Importance 背景 Dexamethasone initiated after the first week of life reduces the rate of death ...
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Research Letter January 15, 2019 Serum Creatinine Levels Before, During, and After Pregnancy Ziv Harel, Eric McArthur, Michelle Hladunewich, et al. JAMA. 2019;321(2):205-207. doi:10.1001/jama.2018.17948 Estimating renal function before and during pregnancy has clinical importance: kidney dysfunction can affect maternal and perinatal health. Glomerular hyperfiltration is a typical physiological adaptation to pregnancy, reflected by a decrease in ...
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Early extubation plus NIV better than standard extubation in hypoxaemic patients In patients recovering from hypoxaemic acute respiratory failure, early extubation followed by immediate noninvasive ventilation (NIV) reduced the days spent on invasive ventilation without affecting intensive care unit (ICU) length of stay. These findings are from a new multicentre randomised controlled trial conducted by Italian and Chinese researchers. Although a post hoc analysis s...
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ORIGINAL ARTICLE Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura Marie Scully, Spero R. Cataland, Flora Peyvandi, et al N Engl J Med January 9, 2019DOI: 10.1056/NEJMoa1806311 Abstract BACKGROUND 背景 In acquired thrombotic thrombocytopenic purpura (TTP), an immune-mediated deficiency of the von Willebrand factor–cleaving protease ADAMTS13 allows unrestrained adhesion of von Willebrand factor multimers to platelets and microthrombo...
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Fatty acids and enteral nutrition in the critically ill Dutch researchers performed a systematic review and meta-analysis of randomised controlled trials of fish oil-containing enteral nutrition addressing relevant clinical outcomes in critically ill patients. Based on the results, they conclude that enteral fish oil supplementation cannot be recommended for these patients as strong scientific evidence for improved clinical benefits could not be found."There is a s...
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ONLINE FIRST THIS WEEK(FREE ACCESS) Imaging in Intensive Care Medicine ~ Mutlu Uysal Yazici - A rare cause of laryngeal stenosis  Original ~ Julien Amour - The effect of local anesthetic continuous wound infusion for the prevention of postoperative pneumonia after on-pump cardiac surgery with sternotomy: the STERNOCAT randomized clinical trial  Editorial ~ Guillaume Geri - Lactate kinetics in critically ill: a new prognostic marker o...
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