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Oseltamivir, amantadine, and ribavirin combination antiviral therapy versus oseltamivir monotherapy for the treatment of influenza: a multicentre, double-blind, randomised phase 2 trial John H Beigel, Yajing Bao, Joy Beeler, et al Lancet Infect Dis 2017; 17:1255-1265 Summary Background 背景 Influenza continues to have a substantial socioeconomic and health impact despite a long established vaccination programme and approved antivirals. Preclinical data suggest that comb...
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CONFERENCE REPORTS AND EXPERT PANEL Guidelines for the diagnosis and management of critical illness‑related corticosteroid insufficiency (CIRCI) in critically ill patients (Part II): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017 Stephen M. Pastores, Djillali Annane, Bram Rochwerg, et al Intensive Care Medicine 2017 (in press) doi: 10.1007/s00134-017-4951-5 Community-acquired pneumonia Should corticosteroids be adminis...
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Intensive Care Medicine ALERT Dec 2017 ARTICLES OF THE MONTH EXPERT PANEL ~ Updated Guidelines on Critical illness-related Corticosteroid Insufficiency Annane D et al. Guidelines for the Diagnosis and Management of Critical Illness-Related Corticosteroid Insufficiency (CIRCI) in Critically Ill Patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017 Part II NARRATIVE REVIEW INTERVIEW WITH AUTHOR EXPERT PANEL ...
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Original Investigation December 12, 2017 Development and Validation of a Deep Learning System for Diabetic Retinopathy and Related Eye Diseases Using Retinal Images From Multiethnic Populations With Diabetes Daniel Shu Wei Ting, Carol Yim-Lui Cheung, Gilbert Lim, et al. JAMA. 2017;318(22):2211-2223. doi:10.1001/jama.2017.18152 Abstract Importance 背景 A deep learning system (DLS) is a machine learning technology with potential for screening diabetic retinopathy and r...
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Idiopathic Pulmonary Fibrosis: Killer Without a Cause Mehran Farid-Moayer, MD; Mark P Brady, PA-C | December 5, 2017 Image courtesy of author's practice database. A 71-year-old man comes to the office with complaints of shortness of breath and a dry cough for the last 8 months. His cough has not improved with antibiotics or albuterol inhalers. His other main symptom is fatigue. He reports no significant past medical history, takes no medications, and has no known allergie...
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ORIGINAL ARTICLE Pharmacomechanical Catheter-Directed Thrombolysis for Deep-Vein Thrombosis Suresh Vedantham, Samuel Z. Goldhaber, Jim A. Julian, et al. N Engl J Med 2017; 377:2240-2252 DOI: 10.1056/NEJMoa1615066 BACKGROUND 背景 The post-thrombotic syndrome frequently develops in patients with proximal deep-vein thrombosis despite treatment with anticoagulant therapy. Pharmacomechanical catheter-directed thrombolysis (hereafter “pharmacomechanical thrombolysis”) rapidly re...
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Medical News & Perspectives December 5, 2017 JAMA Network Articles of the Year Jennifer Abbasi JAMA. 2017;318(21):2065-2068. doi:10.1001/jama.2017.17346 Which articles published in the JAMA Network of journals resonated with readers the most this year—and why? Those are the questions we set out to answer in our first-ever end-of-year roundup. We did an accounting of all Original Investigations and Special Communications published in our journals between September 1...
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Drugs & Diseases > Clinical Trends Clinical Trends for November 2017 Ryan Syrek December 01, 2017 Each week, we identify one top search term, speculate as to what caused its popularity, and provide an infographic on a related condition. If you have thoughts about what's trending and why, feel free to share them with us on Twitter or Facebook! Clinical Trend of the Week (November 25 – December 1): Legionnaires Disease News from both coasts of America resulted in t...
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Prehospital antibiotics in the ambulance for sepsis: a multicentre, open label, randomised trial Nadia Alam, Erick Oskam, Patricia M Stassen, et al. Lancet Respir Med 2017 Published: 28 November 2017 DOI: http://dx.doi.org/10.1016/S2213-2600(17)30469-1 Summary Background 背景 Emergency medical services (EMS) personnel have already made substantial contributions to improving care for patients with time-dependent illnesses, such as trauma and myocardial infarction. Patien...
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Perspective > Critical Issues COMMENTARY Protocolized APRV Versus Assist Control for ARDS Aaron B. Holley, MD November 27, 2017 Settling the APRV in ARDS Debate The 2017 American Thoracic Society/European Respiratory Society guidelines on mechanical ventilation for acute respiratory distress syndrome (ARDS)[1]failed to address airway-pressure release ventilation (APRV). Although many consider APRV to be a "rescue mode" for refractory hypoxemia,[2] others argue that...
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