Acute pain in the ICU: management beyond the usual therapeutic strategies At this year’s Euroanaesthesia 2019 in Vienna, Austria, Prof. Caterina Aurilio (Naples, Italy), talked about acute pain management in the ICU. She started her presentation with the definition of pain as outlined by the International Association for the Study of Pain (IASP). Pain is an "unnecessary sensory and emotional experience associated with actual or potential tissue damage, or desc...

ARTICLES| VOLUME 19, ISSUE 6, P601-610, JUNE 01, 2019 Effect of carbapenem resistance on outcomes of bloodstream infection caused by Enterobacteriaceae in low-income and middle-income countries (PANORAMA): a multinational prospective cohort study Andrew J Stewardson, Kalisvar Marimuthu, Sharmila Sengupta, et al Lancet Infect Dis 2019; 19: 601-610 Summary Background 背景 Low-income and middle-income countries (LMICs) are under-represented i...

ONLINE FIRST THIS WEEK(FREE ACCESS) Review ~ Assoun S. - Molecular targeted therapy-related life-threatening toxicity in patients with malignancies. A systematic review of published cases Original ~ Haines K. J. - Key mechanisms by which post-ICU activities can improve in-ICU care: results of the international THRIVE collaboratives Imaging in Intensive Care Medicine ~ Salden R. L. T. N. - Camel shape in transpulmonary thermodilution monitoringWhat's new in intensive ca...

ARTICLES|ONLINE FIRST Association between urinary dickkopf-3, acute kidney injury, and subsequent loss of kidney function in patients undergoing cardiac surgery: an observational cohort study Stefan J Schunk, Alexander Zarbock, Melanie Meersch, et al Lancet Published:June 12, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)30769-X Summary Background 背景 Cardiac surgery is associated with a high risk of postoperative acute kidney injury (AKI) and sub...

Highlights from the pro-con debate on guidelines At this year’s Euroanaesthesia Congress #EA19, there was a short debate on the topic of guidelines. Talking about the pros was Edoardo De Robertis, Past-Chair, ESA Guidelines Committee, University of Perugia, Italy, and talking about the cons was Arash Afshari, Chair, ESA Guidelines Committee, Rigshospitalet, Copenhagen, Denmark  Here are some highlights from both sides of the debate! Dr. Arash Afshari“I think tha...

ARTICLES|ONLINE FIRST Chlorhexidine for meatal cleaning in reducing catheter-associated urinary tract infections: a multicentre stepped-wedge randomised controlled trial Oyebola Fasugba, Prof Allen C Cheng, Victoria Gregory, et al Lancet Infect Dis Published: April 12, 2019 DOI: https://doi.org/10.1016/S1473-3099(18)30736-9 Summary Background 背景 Evidence for the benefits of antiseptic meatal cleaning in reducing catheter-associated urinary tract i...

小剂量阿奇霉素可能减少COPD急性加重住院患者的治疗失败。这是American Journal of Respiratory and Critical Care Medicine杂志在线发表的一项多中心随机对照试验的结果。 既往研究表明，阿奇霉素能够预防COPD的急性加重。然而，尚不清楚这种抗生素如何能够COPD急性加重的住院患者强化治疗的需求，或者在上述患者出院后为何能够减少急性加重的风险。 在新的研究中，即比利时阿奇霉素治疗COPD加重住院患者研究(BACE)，除住院期间的其他用药外，患者使用小剂量阿奇霉素，并在出院后继续使用小剂量阿奇霉...

ICU Management & Practice, Volume 18 - Issue 2, 2018 Is pre-hospital coagulation management in trauma feasible? Coagulation management remains a formidable challenge in severely bleeding trauma patients. A strong rationale suggests starting treatment of trauma-induced coagulopathy in the pre-hospital phase.The burden of trauma is increasing worldwide, particularly in less well-resourced nations. There are an estimated 5 million deaths per year, more than TB...

Original Investigation April 29, 2019 Diagnostic Performance of Creatinine-Based Equations for Estimating Glomerular Filtration Rate in Adults 65 Years and Older Luciano da Silva Selistre, Dener L. Rech, Vandréa de Souza, et al JAMA Intern Med. Published online April 29, 2019. doi:10.1001/jamainternmed.2019.0223 Abstract Importance 背景 Estimating glomerular filtration rate (GFR) is useful in many clinical conditions. However, very few stu...

Azithromycin may reduce treatment failure in acute COPD exacerbations Low‐dose azithromycin may reduce treatment failure in patients hospitalised for acute exacerbations of chronic obstructive pulmonary disease (COPD). This finding is from a multicentre, randomised controlled trial published online in the American Journal of Respiratory and Critical Care Medicine. The antibiotic azithromycin prevents acute exacerbations in COPD as shown in previous studies. It w...