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Original Investigation Caring for the Critically Ill Patient September 27, 2017 Effect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs Low PEEP on Mortality in Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial Writing Group for the Alveolar Recruitment for Acute Respiratory Distress Syndrome Trial (ART) Investigators JAMA. Published online September 27, 2017. doi:10.1001/jama.2017.14171 Abstract Importance ...
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Original Investigation Caring for the Critically Ill Patient September 27, 2017 Effect of Systematic Intensive Care Unit Triage on Long-term Mortality Among Critically Ill Elderly Patients in France: A Randomized Clinical Trial Bertrand Guidet, Guillaume Leblanc, Tabassome Simon, et al JAMA. Published online September 27, 2017. doi:10.1001/jama.2017.13889  Abstract Importance 背景 The high mortality rate in critically ill elderly patients has led to questioning of...
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Original Investigation Caring for the Critically Ill Patient September 27, 2017 Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and HypotensionA Randomized Clinical Trial Ben Andrews, Matthew W. Semler, Levy Muchemwa, et al JAMA. Published online September 27, 2017. doi:10.1001/jama.2017.10913 Abstract Importance 背景 The effect of an early resuscitation protocol on sepsis outcomes in developing countries remains unknow...
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Original Investigation Caring for the Critically Ill Patient September 13, 2017 Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014 Chanu Rhee, Raymund Dantes, Lauren Epstein, et al. JAMA. Published online September 13, 2017. doi:10.1001/jama.2017.13836 Abstract Importance 背景 Estimates from claims-based analyses suggest that the incidence of sepsis is increasing and mortality rates from sepsis are decreasing. However, estimates...
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Severity of Hypoxemia and Effect of High-Frequency Oscillatory Ventilation in Acute Respiratory Distress Syndrome  Maureen O. Meade, Duncan Young, Steven Hanna, et al. Am J Respir Crit Care Med 2017; 196: 727-733 Abstract Rationale: 背景 High-frequency oscillatory ventilation (HFOV) is theoretically beneficial for lung protection, but the results of clinical trials are inconsistent, with study-level meta-analyses suggesting no significant effect on mortality. 高...
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CORRESPONDENCE Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis N Engl J Med 2017; 377:994-995 DOI: 10.1056/NEJMc1708979 The authors reply: In response to Saleh: we do not have specific information on monitoring in the usual-care (control) groups. However, all three original trials1-3 were conducted at sites that did not systematically apply any protocolized approach to resuscitation of patients with sepsis as part of usual care and, by definit...
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News H7N9 Avian Flu Continues to Spread, Worsen in China Janis C. Kelly September 12, 2017 The latest epidemic of Asian lineage avian influenza A (Asian H7N9) in China infected almost as many patients as the four previous outbreaks combined and gave rise to a variant less susceptible to available treatments and vaccines, researchers report in an article  published in the September 8 issue of the Morbidity and Mortality Weekly Report. 研究人员在Morbidity and Mortality ...
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News > Reuters Health Information Hypervirulent Carbapenem-resistant Klebsiella Pneumoniae Emerges By Will Boggs MD September 08, 2017 NEW YORK (Reuters Health) - An ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae caused a fatal outbreak in a Chinese hospital and could pose a threat elsewhere, researchers report. 研究人员报告,一种ST11耐碳青霉烯高毒力肺炎克雷白杆菌在一家中国医院内导致致死性暴发流行,且可能对其他地区造成危害。 “This new type of superbug...
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A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study. Gu D, Dong N, Zheng Z, et al. Lancet Infect Dis. 2017 Aug 29. pii: S1473-3099(17)30489-9. doi: 10.1016/S1473-3099(17)30489-9. [Epub ahead of print] Abstract BACKGROUND: 背景 Hypervirulent Klebsiella pneumoniae strains often cause life-threatening community-acquired infections in young and healthy hosts, but are usually sensitive to an...
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CORRESPONDENCE Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis N Engl J Med 2017; 377:994-995 DOI: 10.1056/NEJMc1708979 To the Editor: 致编辑 In reporting the results of their meta-analysis of individual patient data from three trials, the Protocolized Resuscitation in Sepsis Meta-Analysis (PRISM) investigators (June 8 issue)1 conclude that early, goal-directed therapy (EGDT) did not result in better outcomes than usual care in the resuscit...
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