Research Christmas 2020: The Citadel Toxicological analysis of George’s marvellous medicine: literature review Graham Johnson, Patrick Davies BMJ 2020; 371: m4467 doi: https://doi.org/10.1136/bmj.m4467 (Published 10 December 2020) Abstract Objective To analyse the therapeutic effects and toxicity of the eponymous concoction described in Roald Dahl’s book George’s Marvellous Medicine. Design Literature review. Setting Two literature lovin...

ORIGINAL ARTICLE A Cluster-Randomized Trial of Hydroxychloroquine for Prevention of Covid-19 Oriol Mitjà, Marc Corbacho-Monné, Maria Ubals, et al N Engl J Med November 24, 2020DOI: 10.1056/NEJMoa2021801 Abstract BACKGROUND Current strategies for preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are limited to nonpharmacologic interventions. Hydroxychloroquine has been proposed as a postexposure therapy to prevent coronavir...

Research Christmas 2020: Grey’s Anatomy The Babinski sign in Renaissance paintings—a reappraisal of the toe phenomenon in representations of the Christ Child: observational analysis François Sellal, Laurent Tatu BMJ 2020;371:m4556 doi: https://doi.org/10.1136/bmj.m4556 (Published 10 December 2020)Cite this as:  Abstract Objective To investigate systematically the presence of the Babinski sign in paintings of the Christ Child by the greatest painters...

Original Investigation July 15, 2020 Risk Factors Associated With Mortality Among Patients With COVID-19 in Intensive Care Units in Lombardy, Italy Giacomo Grasselli, Massimiliano Greco, Alberto Zanella, et al JAMA Intern Med. 2020;180(10):1345-1355. doi:10.1001/jamainternmed.2020.3539 Abstract Importance Many patients with coronavirus disease 2019 (COVID-19) are critically ill and require care in the intensive care unit (ICU). Objective To ev...

Research Christmas 2020: Dr Strange Effect of therapeutic suggestions during general anaesthesia on postoperative pain and opioid use: multicentre randomised controlled trial Hartmuth Nowak, Nina Zech, Sven Asmussen, et al BMJ 2020; 371: m4284 doi: https://doi.org/10.1136/bmj.m4284 (Published 10 December 2020) Abstract Objective To investigate the effect of therapeutic suggestions played to patients through earphones during surgery on postoperative ...

Original Investigation July 1, 2020 Estimation of Excess Deaths Associated With the COVID-19 Pandemic in the United States, March to May 2020 Daniel M. Weinberger, Jenny Chen, Ted Cohen, et al JAMA Intern Med. 2020;180(10):1336-1344. doi:10.1001/jamainternmed.2020.3391 Abstract Importance Efforts to track the severity and public health impact of coronavirus disease 2019 (COVID-19) in the United States have been hampered by state-level differences in...

Research Christmas 2020: The Citadel The shared risk of diabetes between dog and cat owners and their pets: register based cohort study Rachel Ann Delicano, Ulf Hammar, Agneta Egenvall, et al BMJ 2020;371:m4337 doi: https://doi.org/10.1136/bmj.m4337 (Published 10 December 2020) Abstract Objective To investigate whether dog and cat owners and their pets share a risk of developing diabetes. Design Cohort study. Setting Register based longi...

Original Investigation December 8, 2020 Effect of Co-trimoxazole (Trimethoprim-Sulfamethoxazole) vs Placebo on Death, Lung Transplant, or Hospital Admission in Patients With Moderate and Severe Idiopathic Pulmonary Fibrosis: The EME-TIPAC Randomized Clinical Trial Andrew M. Wilson, Allan B. Clark, Tony Cahn, et al JAMA. 2020;324(22):2282-2291. doi:10.1001/jama.2020.22960 Abstract Importance Idiopathic pulmonary fibrosis (IPF) has a poor pr...

Viewpoint December 17, 2020 COVID-19 as the Leading Cause of Death in the United States Steven H. Woolf, Derek A. Chapman, Jong Hyung Lee JAMA. Published online December 17, 2020. doi:10.1001/jama.2020.24865 The current exponential increase in coronavirus disease 2019 (COVID-19) is reaching a calamitous scale in the United States, potentially overwhelming the health care system and causing substantial loss of life. The news media dutifully repor...

Research Letter October 30, 2020 Peripheral Oxygen Saturation in Older Persons Wearing Nonmedical Face Masks in Community Settings Noel C. Chan, Karen Li; Jack Hirsh JAMA. 2020;324(22):2323-2324. doi:10.1001/jama.2020.21905 Based on the evidence that nonmedical face masks prevent the spread of severe acute respiratory syndrome coronavirus 2,1,2 many governments are mandating the wearing of masks in the community. However...