ORIGINAL ARTICLE Nirmatrelvir Use and Severe Covid-19 Outcomes during the Omicron Surge Ronen Arbel, Yael Wolff Sagy, Moshe Hoshen, et al N Engl J Med August 24, 2022DOI: 10.1056/NEJMoa2204919 Abstract BACKGROUND The oral protease inhibitor nirmatrelvir has shown substantial efficacy in high-risk, unvaccinated patients infected with the B.1.617.2 (delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Data regarding the effective...

US Preventive Services Task Force  Evidence Report August 23/30, 2022 Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force Roger Chou, Amy Cantor, Tracy Dana, et al JAMA. 2022;328(8):754-771. doi:10.1001/jama.2022.12138 Abstract Importance  A 2016 review for the US Preventive Services Task Force (USPSTF) found use of s...

ARTICLES|ONLINE FIRST Onset and window of SARS-CoV-2 infectiousness and temporal correlation with symptom onset: a prospective, longitudinal, community cohort study Seran Hakki, Jie Zhou, Jakob Jonnerby, et al Lancet Respir Med Published: August 18, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00226-0 Summary Background Knowledge of the window of SARS-CoV-2 infectiousness is crucial in developing policies to curb transmission. Mathematical modelling...

Original Investigation  August 23/30, 2022 Effect of Aspirin vs Enoxaparin on Symptomatic Venous Thromboembolism in Patients Undergoing Hip or Knee Arthroplasty: The CRISTAL Randomized Trial CRISTAL Study Group JAMA. 2022;328(8):719-727. doi:10.1001/jama.2022.13416 Key Points Question  Is aspirin monotherapy noninferior to enoxaparin in preventing symptomatic venous thromboembolism (VTE) within 90 days following primary total hip...

EDITORIALFREE PREVIEW Fluid Resuscitation in Acute Pancreatitis — Going over the WATERFALL Timothy B. Gardner N Engl J Med 2022; 387:1038-1039DOI: 10.1056/NEJMe2209132 Acute pancreatitis, responsible for approximately 300,000 hospital admissions in the United States annually, is characterized by intense inflammation of the pancreas that leads to severe disease in approximately one third of affected patients.1 Because no proven pharmacologic therapy for acute p...

ORIGINAL ARTICLE Lower versus Higher Glycemic Criteria for Diagnosis of Gestational Diabetes Caroline A. Crowther, Deborah Samuel, Lesley M.E. McCowan, et al N Engl J Med 2022; 387:587-598DOI: 10.1056/NEJMoa2204091 Abstract BACKGROUND Treatment of gestational diabetes improves maternal and infant health, although diagnostic criteria remain unclear. METHODS We randomly assigned women at 24 to 32 weeks’ gestation in a 1:1 ratio to be evaluated for ge...

ORIGINAL ARTICLE Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19 Carolyn T. Bramante, Jared D. Huling, Christopher J. Tignanelli, et al N Engl J Med 2022; 387:599-610DOI: 10.1056/NEJMoa2201662 Abstract BACKGROUND Early treatment to prevent severe coronavirus disease 2019 (Covid-19) is an important component of the comprehensive response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. METHODS In ...

Original Investigation  August 16, 2022 Association of COVID-19 vs Influenza With Risk of Arterial and Venous Thrombotic Events Among Hospitalized Patients Vincent Lo Re III, Sarah K. Dutcher, John G. Connolly, et al JAMA. 2022;328(7):637-651. doi:10.1001/jama.2022.13072 Key Points Question  Is the 90-day incidence of arterial thromboembolism and venous thromboembolism higher in patients hospitalized with COVID-19 vs in patients ...

ORIGINAL ARTICLEFREE PREVIEW A Randomized Trial of Enteral Glutamine for Treatment of Burn Injuries Daren K. Heyland, Lucy Wibbenmeyer, Jonathan A. Pollack, et al N Engl J Med 2022; 387:1001-1010DOI: 10.1056/NEJMoa2203364 Abstract BACKGROUND Glutamine is thought to have beneficial effects on the metabolic and stress response to severe injury. Clinical trials involving patients with burns and other critically ill patients have shown conflicting results re...

Original Investigation  August 9, 2022 Association of Dual Antiplatelet Therapy With Ticagrelor With Vein Graft Failure After Coronary Artery Bypass Graft Surgery: A Systematic Review and Meta-analysis Sigrid Sandner, Björn Redfors, Dominick J. Angiolillo, et al JAMA. 2022;328(6):554-562. doi:10.1001/jama.2022.11966 Key Points Question  Is ticagrelor dual antiplatelet therapy (DAPT) for patients undergoing coronary artery bypass ...